Comparison of gradual and rapid onset runs in a short-arm centrifugation

Miyamoto, Akira; Saga, K.; Kinoue, Takaaki; Nakazato, Tatsuo; Hirayanagi, Kaname; Yajima, Kazuyoshi; Hayashi, Sotaro; Matsumoto, Shigemi

doi:10.1016/0094-5765(95)00158-1

Cited by 3 publications

(4 citation statements)

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“…Compounding this will be the effects of cosmic radiation, loss of circadian rhythm and other challenges to physical and mental health. To prevent loss of bone mineral and certain cardiovascular changes, artificial gravity has been studied [1,2,3,4,5,6,7,8] and may be required urgently as an essential counter-measure for the upcoming manned mission to Mars.…”

Section: Introductionmentioning

confidence: 99%

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Can daily centrifugation prevent the haematocrit increase elicited by 6-degree, head-down tilt?

Yajima

Iwasaki

Sasaki

et al. 2000

Pflügers Arch - Eur J Physiol

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A measure to counteract the effects of low or zero gravity is required for long-term space flight, such as the manned Mars mission scheduled by the National Aeronautics and Space administration (NASA) for 2014. We conducted a series of centrifugation experiments with humans, using a short-arm centrifuge (radius 1.8 m, made by First Medical Co., Tokyo, Japan). We employed 6-degree, head-down tilt (HDT) for 4 days to simulate space flight. Ten healthy male volunteers underwent 4-day HDT and a 2-G daily centrifuge load for 60 min in the +Gz direction and measurements, such as haematocrit, 24-h urine volume, body weight and electrocardiogram (ECG) were made. There was no significant increase in the haematocrit during the HDT period, although our previous studies had shown a significant increase during HDT. A 60-min daily load of +2 Gz appears to be effective in reversing the haematocrit increase due to 4-day HDT.

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Section: Introductionmentioning

confidence: 99%

“…Over the last 10 years we have conducted a series of human centrifugation experiments [3,4,5,6,7,8] using a short-arm human centrifuge. From these studies we concluded that 60 min daily centrifugation can prevent the haematocrit increase in subjects exposed to 6-degree head-down tilt (HDT) for 4 days.…”

Section: Introductionmentioning

confidence: 99%

Can daily centrifugation prevent the haematocrit increase elicited by 6-degree, head-down tilt?

Yajima

Iwasaki

Sasaki

et al. 2000

Pflügers Arch - Eur J Physiol

View full text Add to dashboard Cite

show abstract

“…Published reports of blood pressure changes with the onset of shortradius centrifugation have shown a somewhat inconsistent pattern. For example, the study by Miyamoto et al (1995) showed an increase in mean arterial blood pressure that paralleled the increase in gravity level during onset and rose from about 70 mmHg to 90 mmHg with the application of 2.2 g along Gz. Another study reported very small decreases in systolic blood pressure along with slight increases in diastolic blood pressure (Vil-Viliams et al 2004).…”

Section: Blood Pressurementioning

confidence: 97%

“…A sustained baroreceptor-mediated increase in heart rate is expected during centrifugation. The percentage increase compared to that for a supine subject can easily be 40-60% and is dependent on the applied g level (Vil-Viliams et al 2004, Miyamoto et al 1995. This is a similar 41 Prodromal symptoms are symptoms symptomatic of the onset of a medical event or a disease.…”

Section: Heart Ratementioning

confidence: 99%