Comparison of global strain values of myocardium in beta-thalassemia major patients with iron load using specific feature tracking in cardiac magnetic resonance imaging

Rezaeian, Nahid; Mohtasham, Masoumeh Ahmadi; Khaleel, Azad Jameel; Parnianfard, Neda; Kasani, Kianoosh; Golshan, Rosa

doi:10.1007/s10554-020-01835-3

Cited by 24 publications

(27 citation statements)

References 31 publications

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“…For instance, it has been reported that feature-trackingderived strain parameters in CMR correlate with myocardial T2* values and are considered valuable tools for the early detection of MIO, which can modify chelation therapy. 25 The remarkable finding of our study was the predictive role of biventricular GLS and GCS concerning IHpPH in patients with thalassemia.…”

Section: Discussionmentioning

confidence: 57%

“…The utility of CMR strain values in patients with thalassemia has been previously investigated in a few studies. For instance, it has been reported that feature‐tracking‐derived strain parameters in CMR correlate with myocardial T2* values and are considered valuable tools for the early detection of MIO, which can modify chelation therapy 25 …”

Section: Discussionmentioning

confidence: 99%

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The predictive role of cardiac magnetic resonance imaging in determining thalassemia patients with intermediately to highly probable pulmonary hypertension

et al. 2021

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Objectives:We sought to determine the cardiac magnetic resonance (CMR) indicators of intermediately to highly probable pulmonary hypertension (IHpPH) in patients with thalassemia referred for myocardial iron overload assessments to prevent further cardiac complications. Methods:The study population consisted of 152 patients with thalassemia (major or intermedia) (49.3% women, mean age = 33 ± 10.1 years) who underwent non-contrast CMR and echocardiographic examinations on the same day. Functional, T2*, and global strain parameters via a feature-tracking method were extracted from CMR. The probability of PH was defined based on the tricuspid regurgitation velocity and echocardiographic parameters. The catheterization-derived hemodynamic data of patients with moderate to high probable PH was registered.Results: Twenty-two (14.5%) patients suffered from IHpPH. The multivariate logistic regression analysis revealed that the right ventricular end-systolic volume index (RVESVI) was the strongest of all the CMR parameters for the prediction of IHpPH (OR:1.044, 95% CI: 1.021-1.067). The other powerful IHpPH predictor was age (OR: 1.066, 95% CI: 1.009-1.126). A cutoff point of greater than 47 ml for RVESVI (AUC: .801, 95% CI: .728-.861) was found to predict IHpPH with 73.91% sensitivity and 70.31% specificity. The single most robust CMR-derived strain parameter for IHpPH prediction was the right ventricular global longitudinal strain (OR: .887, 95% CI: .818-.961). A p value of less than 0.05 was considered significant. Conclusions:Both CMR functional and global strain parameters were strong predictors of IHpPH in our patients with thalassemia. K E Y W O R D Scardiac magnetic resonance (CMR), intermediately to highly probable pulmonary hypertension (IHpPH), pulmonary hypertension (PH), thalassemia INTRODUCTIONThalassemia, considered the most typical of all hereditary disorders, results in the diminished or absent synthesis of hemoglobin chains. 1Globally, there are approximately 270 million carriers of various hemoglobinopathies, of whom 30% are carriers of β-thalassemia. 2 Cardiac complications persist as the main cause of morbidity and the leading cause of mortality in these patients. [3][4][5][6] Heart injury due to myocardial iron overload (MIO) is not completely reversible. There are multiple causes of cardiac disease, especially in older thalassemia

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

The predictive role of cardiac magnetic resonance imaging in determining thalassemia patients with intermediately to highly probable pulmonary hypertension

et al. 2021

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“…Furthermore, CMR-FT detected lower RV strain in patients with convalescent Kawasaki disease and RV functional impairment was more pronounced in those with persisting coronary artery lesion [91]. Another study showed high iron deposition in the myocardium to be detectable including CMR-FT-derived RV deformation and therefore timely modification and chelation therapy may be navigated by this non-invasive imaging approach [92]. Subclinical myocardial involvement in the form of both strain impairment and increased dyssynchrony was also detected by CMR-FT analyses in patients with cocaine addiction [93].…”

Section: Myocardial Inflammation and Other Cardiac Disordersmentioning

confidence: 96%

Quantification of Myocardial Deformation Applying CMR-Feature-Tracking—All About the Left Ventricle?

Lange

Schuster

2021

Curr Heart Fail Rep

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Purpose of Review Cardiac magnetic resonance-feature-tracking (CMR-FT)-based deformation analyses are key tools of cardiovascular imaging and applications in heart failure (HF) diagnostics are expanding. In this review, we outline the current range of application with diagnostic and prognostic implications and provide perspectives on future trends of this technique. Recent Findings By applying CMR-FT in different cardiovascular diseases, increasing evidence proves CMR-FT-derived parameters as powerful diagnostic and prognostic imaging biomarkers within the HF continuum partly outperforming traditional clinical values like left ventricular ejection fraction. Importantly, HF diagnostics and deformation analyses by CMR-FT are feasible far beyond sole left ventricular performance evaluation underlining the holistic nature and accuracy of this imaging approach. Summary As an established and continuously evolving technique with strong prognostic implications, CMR-FT deformation analyses enable comprehensive cardiac performance quantification of all cardiac chambers.

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“…ere have also been investigations suggesting the superiority of DWI over LGE owing to such probable advantages as the capability to show both diffuse scarring in the early stages of HCM [10,12] and fibrotic areas that are not well visualized by LGE [12]. Additionally, the relatively novel technique of feature-tracking cardiac magnetic resonance (FT-CMR) has proven its efficaciousness in some cardiac disorders by assisting in diagnosis, risk stratification, and prognostication [13][14][15][16][17][18]. Since FT-CMR is a contrast-free method and is feasible through a postprocessing analysis of routine cine images, it can act as a practical, available, and cost-beneficial method in the diagnosis of areas with myocardial fibrosis.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Novel Noncontrast Cardiac Magnetic Resonance Methods in Indicating Fibrosis in Hypertrophic Cardiomyopathy

Sharifian

Rezaeian

Asadian

et al. 2021

Cardiology Research and Practice

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Objective. In hypertrophic cardiomyopathy (HCM), myocardial fibrosis is routinely shown by late gadolinium enhancement (LGE) in cardiac magnetic resonance (CMR) imaging. We evaluated the efficacy of 2 novel contrast-free CMR methods, namely, diffusion-weighted imaging (DWI) and feature-tracking (FT) method, in detecting myocardial fibrosis. Methods. This cross-sectional study was conducted on 26 patients with HCM. Visual and quantitative comparisons were made between DWI and LGE images. Regional longitudinal, circumferential, and radial strains were compared between LGE-positive and LGE-negative segments. Moreover, global strains were compared between LGE-positive and LGE-negative patients as well as between patients with mild and marked LGE. Results. All 3 strains showed significant differences between LGE-positive and LGE-negative segments ( P < 0.001 ). The regional longitudinal and circumferential strain parameters showed significant associations with LGE ( P < 0.001 ), while regional circumferential strain was the only independent predictor of LGE in logistic regression models (OR: 1.140, 95% CI: 1.073 to 1.207, P < 0.001 ). A comparison of global strains between patients with LGE percentages of below 15% and above 15% demonstrated that global circumferential strain was the only parameter to show impairment in the group with marked myocardial fibrosis, with borderline significance ( P = 0.09 ). A review of 212 segments demonstrated a qualitative visual agreement between DWI and LGE in 193 segments (91%). The mean apparent diffusion coefficient was comparable between LGE-positive and LGE-negative segments ( P = 0.51 ). Conclusions. FT-CMR, especially regional circumferential strain, can reliably show fibrosis-containing segments in HCM. Further, DWI can function as an efficient qualitative method for the estimation of the fibrosis extent in HCM.

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Comparison of global strain values of myocardium in beta-thalassemia major patients with iron load using specific feature tracking in cardiac magnetic resonance imaging

Cited by 24 publications

References 31 publications

The predictive role of cardiac magnetic resonance imaging in determining thalassemia patients with intermediately to highly probable pulmonary hypertension

The predictive role of cardiac magnetic resonance imaging in determining thalassemia patients with intermediately to highly probable pulmonary hypertension

Quantification of Myocardial Deformation Applying CMR-Feature-Tracking—All About the Left Ventricle?

Efficacy of Novel Noncontrast Cardiac Magnetic Resonance Methods in Indicating Fibrosis in Hypertrophic Cardiomyopathy

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