Comparison of Glaucoma Detection Performance of Binocular Perimetry Screening Program Using imo Perimetry With Frequency Doubling Technology

Abstract

Purpose We aimed to preliminarily compare the glaucoma detection accuracy of a head-mounted binocular visual perimeter “imo” screening program (ISP) with that of frequency doubling technology (FDT). Methods This multicenter, diagnostic accuracy study based on prospectively collected data included 76 non-glaucoma (including pre-perimetric glaucoma) eyes and 92 glaucomatous eyes from patients visiting two hospitals. Patients underwent ISP and FDT (C-20-1 screening program) on the same day. Diagnostic efficacy was evaluated using receiver operating characteristic curves and areas under the curve (AUCs). In addition, we compared the ISP and FDT testing times. Results AUC values for ISP versus FDT were as follows: (1) mild-stage glaucoma (mean deviation [MD] > –6 dB), 0.82 (95% confidence interval [CI], 0.75–0.88) versus 0.76 (95% CI, 0.68–0.83); moderate-stage glaucoma (–6 dB ≥ MD ≥ –12 dB), 0.98 (95% CI, 0.95–1.00) versus 0.96 (95% CI, 0.93–1.00); and advanced-stage glaucoma (–12 dB > MD), 1.00 (95% CI, 1.00–1.00) versus 0.99 (95% CI, 0.98–1.00). In addition, mild-stage glaucoma was classified into two stages (MD > –3 D) and (–3 D ≥ MD > –6 D). AUC values were 0.81 (95% CI, 0.73–0.88) versus 0.76 (95% CI, 0.68–0.84) for MD > –3 D and 0.86 (95% CI, 0.77–0.94) versus 0.73 (95% CI, 0.61–0.86) for –3 D ≥ MD > –6 D. The testing time for the ISP was significantly shorter than that of FDT for all glaucoma stages ( P < 0.001). Conclusions The ISP demonstrates non-inferiority in detecting glaucoma and has a shorter testing time compared with FDT. These findings provide evidence for applied further studies on large-scale population-based glaucoma screening. Translational Relevance Our study provides a non-inferior and quicker glaucoma screening than existing tools.