Comparison of genotoxicity potentials between crude Thai bee pollen and its extracts

Ratanavalachai, Treetip; Thitiorul, S; Jenkhetkan, Wantha; Jansom, Chalerm; Itharat, Arunporn

doi:10.1055/s-0036-1596573

Cited by 1 publication

(2 citation statements)

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“…Another method demonstrated the genoprotective effect of bee pollen, especially the extracted lipid fraction, against damage to the genetic material of human lymphocytes caused by doxorubicin [23]. Among other bee products, the greatest genoprotective potential was shown for propolis [25]. Other studies suggest that the protective effect of bee products against DNA damage caused by chemical agents (e.g., benzo(a)pyrene) is related to their antioxidant activity and the polyphenols they contain [26].…”

Section: Biological Activity Using the Yeast Modelmentioning

confidence: 99%

“…The genoprotective effect, i.e., the protection of the genetic material of cells against damage caused by various physical and chemical factors, is one of the new fields of research on natural products [20,21]. Such an effect so far has been demonstrated for many bee products, including honey [22], bee pollen [23], royal jelly [24], and propolis [25]. However, bee bread, alone or in combination with honey, has not been studied for its genoprotective effect.…”

Section: Introductionmentioning

confidence: 99%

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The Comparison of Honey Enriched with Laboratory Fermented Pollen vs. Natural Bee Bread in Terms of Nutritional and Antioxidant Properties, Protein In Vitro Bioaccessibility, and Its Genoprotective Effect in Yeast Cells

et al. 2023

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The aim of the study was to compare the nutritional value and bioactivity of honey enriched with a 10% addition of natural bee bread and its substitutes obtained as a result of laboratory fermentation of bee pollen. Physicochemical parameters, antioxidant properties, as well as the bioaccessibility of proteins using an in vitro static digestion model were analyzed. The bioactivity of the obtained enriched honeys was tested using the yeast model. The research indicates the similarity of honeys with the addition of “artificial bee bread” to honey with natural ones. During in vitro digestion, good bioaccessibility of the protein from the tested products was demonstrated. The ability of the products to protect yeast cells against hydrogen superoxide-induced oxidative stress was demonstrated using a qualitative spot test, which was stronger in the case of enriched honey than in pure rapeseed control honey. Significant inhibition of the growth of both strains of yeast exposed to bee pollen-enriched honeys was also demonstrated. Furthermore, all tested samples showed significant genoprotective activity against the genotoxic effect of zeocin and the reduction of the number of DNA double-strand breaks by a minimum of 70% was observed.

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Section: Biological Activity Using the Yeast Modelmentioning

confidence: 99%