Comparison of GeneXpert MTB/RIF Assay in Broncho Alveolar Lavage and Gastric Lavage Samples

Mahat, Ravi; Rizvi, Nadeem; Saifullah, Nausheen; Tawfik, Madiha; Kumar, Ashok

doi:10.4236/aid.2016.63014

Cited by 2 publications

(2 citation statements)

References 16 publications

(16 reference statements)

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“…Earlier study shows that the GeneXpert for MTB in BAL fluid has been found to be positive in 48.6%. 9 The present study shows that in 25 cases, direct smear was found to be negative, but in GeneXpert was negative cases in 14 cases. This shows that the GeneXpert in BAL plays a vital role in diagnosing TB patients as compared with that of direct smear for MTB in BAL.…”

Section: Methodssupporting

confidence: 40%

Role of Genexpert in Detecting MTB in Bal Fluid From Sputum-Negative Pulmonary Tb Suspects

Ansari¹

2017

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BACKGROUND In India, tuberculosis remains a major public health problem with high mortality and contributing significantly to world tuberculosis burden. Early diagnosis still remains a challenge and GeneXpert, a molecular test helps in detecting tuberculosis as early as within two hours. In the present study, role of GeneXpert for detecting MTB (mycobacterium tuberculosis) in bronchial lavage of tuberculosis suspects has been reported. Total 36 cases were reported and GeneXpert is found to be positive for MTB in 22 cases and compared with direct smear and cultures of BAL (bronchoalveolar lavage) fluid for MTB.

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Section: Methodssupporting

confidence: 40%

Role of Genexpert in Detecting MTB in Bal Fluid From Sputum-Negative Pulmonary Tb Suspects

Ansari¹

2017

jebmh

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“…Similarly, another Pakistani study by Mahat R et al also reported the higher positivity of gastric lavage with GXP 38.9%. 17 Another study of Brown M et al from United Kingdom also reported the pulmonary tuberculosis in 43% patients on evaluation of gastric lavage. Researcher also reports higher positivity of gastric lavage with gene culture 30% followed by smear with 13%.…”

Section: Discussionmentioning

confidence: 95%

Yield & accuracy of Gastric Lavage in non-expectorating adults with Suspected Pulmonary Tuberculosis

et al. 2023

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Objective: To determine the yield of Gastric lavage (GL) in non-expectorating adults with suspected Pulmonary Tuberculosis (PTB) and accuracy of GL-AFB smear with GL-GeneXpert (GXP) by taking AFB culture as gold standard. Methods: Cross-sectional study on suspected PTB patients was done at Ojha Institute of Chest Diseases during period 16th July 2020 till 15th January 2021. Adult patients of either gender suspected to have PTB and not expectorating were included. GL was performed and sent for AFB smear, GXP and AFB culture. Odds ratio, sensitivity and specificity were calculated. Results: After informed written consent, 206 patients, mean age was 38.17 ±17.30 years were inducted, including 89 (43.2%) males and 117 (56.8%) females. Gene Xpert, AFB smear & AFB culture were positive in 83(40%), 50 (24%) & 72 (35%) respectively in GL samples. Odds of PTB were 3.95 times higher among patients with ≤1 month of duration of symptoms (aOR 3.95, 95% CI 1.82-8.57, p-value 0.001), 6.24 times higher among patients with weight loss (aOR 6.24, 95% CI 3.03-12.84, p-value <0.001), and 4.22 times higher among patients with cavitation (aOR 4.22, 95% CI 1.99-8.93, p-value <0.001). GL-AFB smear showed sensitivity 63.89%, specificity 97.01%, positive predicted value 92%, negative predicted value 83.3%, and overall diagnostic accuracy 85.4%. Whereas GL-GXP showed sensitivity 94.4%, specificity 88.81%, positive predicted value 81.93%, negative predicted value 96.75%, and overall diagnostic accuracy 90.78%. Conclusion: Yield of GL significant to detect PTB in suspected cases who are not expectorating. GL-GXP diagnostic accuracy and sensitivity is higher than GL-AFB smear. doi: https://doi.org/10.12669/pjms.39.5.6972 How to cite this: Ghafoor L, Zuberi FF, Khan GM, Ismail M. Yield & accuracy of Gastric Lavage in non-expectorating adults with Suspected Pulmonary Tuberculosis. Pak J Med Sci. 2023;39(5):---------. doi: https://doi.org/10.12669/pjms.39.5.6972 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comparison of GeneXpert MTB/RIF Assay in Broncho Alveolar Lavage and Gastric Lavage Samples

Cited by 2 publications

References 16 publications

Role of Genexpert in Detecting MTB in Bal Fluid From Sputum-Negative Pulmonary Tb Suspects

Role of Genexpert in Detecting MTB in Bal Fluid From Sputum-Negative Pulmonary Tb Suspects

Yield & accuracy of Gastric Lavage in non-expectorating adults with Suspected Pulmonary Tuberculosis

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