Comparison of Gadolinium-DTPA and Macromolecular Gadolinium-DTPA-Polylysine for Contrast-Enhanced Pulmonary Time-of-Flight Magnetic Resonance Angiography

Böck, J. C.; Kaufmann, Frank; Félix, R.

doi:10.1097/00004424-199610000-00007

Cited by 13 publications

(5 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Better than immunohistochemistry, which is limited to a few representative tissue samples, EB NIRF allows the quantification of permeability along the whole rabbit abdominal aorta, thus closely matching the in vivo quantification of permeability by 3D DCE‐MRI. However, EB has a significantly higher molecular weight (66.5 kDa) than Gd‐DTPA [0.547 kDa ], the contrast agent used for 3D DCE‐MRI. This property affects the extravasation rates of the two molecules, with EB–albumin being slower than Gd‐DTPA, and requiring a highly permeable endothelium to extravasate, and may explain the fairly low correlation between ex vivo NIRF and 3D DCE‐MRI.…”

Section: Discussionmentioning

confidence: 99%

Three-dimensional dynamic contrast-enhanced MRI for the accurate, extensive quantification of microvascular permeability in atherosclerotic plaques

et al. 2015

View full text Add to dashboard Cite

Atherosclerotic plaques that cause stroke and myocardial infarction are characterized by increased microvascular permeability and inflammation. Dynamic contrast enhanced (DCE) MRI has been proposed as a method to quantify vessel wall microvascular permeability in vivo. Until now, most DCE-MRI studies have been limited to 2 dimensional (2D), multi-slice imaging. While providing the high-spatial resolution required to image the arterial vessel wall, these approaches do not allow quantifying plaque permeability with extensive anatomical coverage, an essential feature when imaging heterogeneous diseases, such as atherosclerosis. To our knowledge, we present the first systematic evaluation of 3 dimensional (3D), high-resolution, DCE-MRI for the extensive quantification of plaque permeability along an entire vascular bed, with validation in atherosclerotic rabbits. We compare two acquisitions: 3D turbo field echo (TFE) with MSDE preparation (motion sensitized driven equilibrium), and 3D TSE (turbo spin echo). We find 3D TFE DCE-MRI to be superior to 3D TSE DCE-MRI in terms of temporal stability metrics. Both sequences showed good intra and inter-observer reliability, and significant correlation with ex vivo permeability measurements by Evans Blue near infra-red fluorescence (NIRF). Additionally, we explore the feasibility of using compressed sensing to accelerate 3D DCE-MRI of atherosclerosis, to improve its temporal resolution and therefore the accuracy of permeability quantification. Using retrospective under-sampling and reconstructions we show that compressed sensing alone may allow accelerating 3D DCE-MRI up to 4 folds. We anticipate that the development of high spatial resolution 3D DCE-MRI with prospective compressed sensing acceleration may allow for the more accurate and extensive quantification of atherosclerotic plaque permeability along an entire vascular bed. We foresee that this approach may allow for the comprehensive and accurate evaluation of plaque permeability in patients, and may be a useful tool to assess therapeutic response to approved and novel drugs for cardiovascular disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Three-dimensional dynamic contrast-enhanced MRI for the accurate, extensive quantification of microvascular permeability in atherosclerotic plaques

et al. 2015

View full text Add to dashboard Cite

show abstract

“…This phantom was a unique requirement for the reproducible and sufficiently realistic simulation of lung abnormalities in the present study. Respirated animal and human lung explant systems are known from pharmacologic and imaging studies (25)(26)(27), but the models in those studies did not involve the use of a dedicated chest phantom.…”

Section: Discussionmentioning

confidence: 99%

Simulated Pulmonary Nodules Implanted in a Dedicated Porcine Chest Phantom: Sensitivity of MR Imaging for Detection

Biederer

Schoene²,

Freitag³

et al. 2003

Radiology

View full text Add to dashboard Cite

show abstract

“…Conventional MR imaging and MR arthrography have been used to evaluate joint articular cartilage for the past 10 years (14)(15)(16)(17)(18)(19). The technique of delayed gadolinium-enhanced MR imaging of cartilage (dGEMRIC) has been recently applied in clinical studies, and the dGEMRIC measurement of glycosaminoglycan (GAG) has potential for the characterization of hyaline articular cartilage (20)(21)(22)(23)(24)(25).…”

mentioning

confidence: 99%

Comparison study of intraarticular and intravenous gadolinium-enhanced magnetic resonance imaging of cartilage in a canine model

et al. 2008

View full text Add to dashboard Cite

Comparison of Gadolinium-DTPA and Macromolecular Gadolinium-DTPA-Polylysine for Contrast-Enhanced Pulmonary Time-of-Flight Magnetic Resonance Angiography

Abstract: The authors' measurements demonstrate significant improvement of time-of-flight angiograms by low-dose administration of Gd-DTPA-polylysine.

Cited by 13 publications

References 31 publications

Three-dimensional dynamic contrast-enhanced MRI for the accurate, extensive quantification of microvascular permeability in atherosclerotic plaques

Three-dimensional dynamic contrast-enhanced MRI for the accurate, extensive quantification of microvascular permeability in atherosclerotic plaques

Simulated Pulmonary Nodules Implanted in a Dedicated Porcine Chest Phantom: Sensitivity of MR Imaging for Detection

Comparison study of intraarticular and intravenous gadolinium-enhanced magnetic resonance imaging of cartilage in a canine model

Contact Info

Product

Resources

About