Comparison of Functional Magnetic Resonance Imaging for Language Localization and Intracarotid Speech Amytal Testing in Presurgical Evaluation for Intractable Epilepsy

Worthington, Curtis; Vincent, Diana J.; Bryant, Alton E.; Roberts, Donna R.; Vera, Cristián L.; Ross, David A.; George, Mark S.

doi:10.1159/000099874

Cited by 66 publications

(26 citation statements)

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“…Most such studies compare the results of imaging studies of language (PET or fMRI) with those of electrocortical mapping and Amytal. In general, lateralizing measures derived from functional imaging data are concordant with Amytal test results [Desmond et al, 1995;Binder et al, 1996;Hunter et al, 1999;Worthington et al, 1997;Benson et al, 1999;Leblanc et al, 1992], and the locations of activation foci coincide with areas that produce speech arrest and disruption under electrocortical stimulation Fitzgerald et al, 1997;Herholz et al, 1997;Klein et al, 1997;Yetkin et al, 1997;Bittar et al, 1999;Schlosser et al, 1999]. This work is still in its early stages, however.…”

Section: Presurgical Mappingmentioning

confidence: 72%

Functional Imaging of the Auditory System: The Use of Positron Emission Tomography

Johnsrude¹,

Giraud²,

Frackowiak³

2002

Audiol Neurotol

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Modern brain imaging methods now afford unprecedented opportunities for the in vivo study of central auditory system function. Positron emission tomography (PET) has been used as a functional imaging technique for more than 15 years to study the distribution of cerebral haemodynamic changes associated with auditory stimulation, in subjects with normal and abnormal auditory function. Many of these studies concern processes related to, but not identical with, audition, such as speech perception, melodic processing and directed attention. Additionally, PET has been used to explore auditory perception in clinical populations such as cochlear implantees, neurosurgical candidates and people with tinnitus and auditory hallucinations. The spatial resolution of PET does not appear sufficient to address questions of a fine anatomical grain, e.g. exploring functional specialization within the primary and secondary auditory cortex. Nevertheless, PET has considerable potential as a tool in basic research on, and clinical assessment of, many auditory phenomena. Although functional magnetic resonance imaging can now be used for many studies for which formerly only PET was suitable, PET still possesses unique advantages. For example, it permits acquisition of data from inferior frontal and anterior temporal areas, can be used with subjects with cochlear and other implants (such as pacemakers) and can be used to map neurochemical pathways and receptors.

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Section: Presurgical Mappingmentioning

confidence: 72%

Functional Imaging of the Auditory System: The Use of Positron Emission Tomography

Johnsrude¹,

Giraud²,

Frackowiak³

2002

Audiol Neurotol

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“…Our findings confirm the clinical utility of the fMRI tasks used in this study for localization of the eloquent cortex in presurgical evaluation, and are consistent with prior literature. Several studies have already documented the ability of fMRI to lateralize language in patients with epilepsy, and have shown a strong correlation between presurgical fMRI performed using various language tasks and IAP [14,16,18,23,24,29]. For example, Binder and colleagues found a very strong correlation (Pearson's r = 0.96, P < 0.0001), and Desmond and colleagues observed a perfect ("100%") correlation between the IAP and fMRI in the ability to lateralize language in patients with epilepsy [14,16].…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, several studies have compared fMRI and the IAP with respect to language lateralization, or evaluated the ability of fMRI to localize language functions in children and adults with epilepsy [12][13][14][15][16][17][18][19][20][21][22][23][24]. These and other authors used various language fMRI tasks including semantic decision [14,16,21,[25][26][27], verb generation/verbal fluency [13,19,20,23,[28][29][30], word generation [15,18,22,24], and sentence reading [17,31].…”

Section: Introductionmentioning

confidence: 99%

“…These and other authors used various language fMRI tasks including semantic decision [14,16,21,[25][26][27], verb generation/verbal fluency [13,19,20,23,[28][29][30], word generation [15,18,22,24], and sentence reading [17,31]. Some studies have also reported the use of more than one fMRI paradigm for language localization and lateralization [10,12,13,29,32,33], but the results of these studies have been mixed, with some tasks showing good and some poor correlation with the results of IAP.…”

Section: Introductionmentioning

confidence: 99%

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Comprehensive presurgical functional MRI language evaluation in adult patients with epilepsy

Szaflarski

Holland

Jacola

et al. 2008

Epilepsy & Behavior

112

137

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Functional magnetic resonance imaging (fMRI) has the potential to replace the intracarotid amobarbital procedure (IAP) in presurgical evaluation of patients with epilepsy patients. In this study, we compared fMRI verb generation (VG) and semantic decision/tone decision (SDTD) tasks and the IAP in their ability to localize language functions in patients with epilepsy undergoing presurgical evaluation. We enrolled 50 healthy controls to establish normal language activation patterns for VG and SDTD tasks at 3 or 4 T, and to design language regions of interest (ROIs) that were later applied to 38 patients with epilepsy (28 of 38 also underwent the IAP). We calculated laterality indices (LIs) for each task for each subject based on the ROIs, and we used general linear modeling to analyze the fMRI data. All healthy and epileptic subjects activated language areas with both fMRI tasks. We found significant correlations in language lateralization between the fMRI tasks (r = 0.495, P ≤ 0.001) and between VG and IAP (r = 0.652, P < 0.001) and SDTD and IAP (r = 0.735, P < 0.001). The differences in LIs between SDTD and VG tasks were small and not affected by age, gender, epilepsy status, handedness, or performance. SDTD and VG tasks combined explained approximately 58.4% in the variability of the IAP/language. In the general linear modeling, only the SDTD task significantly contributed to the determination of language lateralization in patients with epilepsy undergoing presurgical evaluation. Results indicate a moderate convergent validity between both fMRI language tasks and between IAP and fMRI tasks. The results of this study indicate that either of these fMRI tasks can be used for language lateralization in patients with epilepsy undergoing presurgical evaluation, but that the SDTD task is likely to provide more information regarding language lateralization than the VG task.

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“…These studies are listed in Table 2 with a description of the task employed, region of interest, subject sample size, number of participants with atypical language, concordance or correlation, and activation patterns (Baciu et al 2001;Bahn et al 1997;Benke et al 2006;Benson et al 1999;Binder et al 1996;Carpentier et al 2001;Deblaere et al 2004;Desmond et al 1995;Gaillard et al 2002Gaillard et al , 2004Hertz-Pannier et al 1997;Lehericy et al 2000;Liegeois et al 2002;Rutten et al 2002;Sabbah et al 2003;Spreer et al 2002;Woermann et al 2003;Worthington et al 1997;Yetkin et al 1998). The IAT (Wada 1949) is used routinely and considered the "gold standard" for language lateralization prior to epilepsy surgery, though the procedure provides no information about localization within a hemisphere.…”

Section: Comparisons Between Fmri and The Intracarotid Amobarbital Testmentioning

confidence: 99%

Functional Magnetic Resonance Imaging of Language in Epilepsy

et al. 2007

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Functional magnetic resonance imaging (fMRI) has revolutionized our understanding of functional networks and cerebral organization in both normal and pathological brains. In the present review, we describe the use of fMRI for mapping language in epilepsy patients prior to surgical intervention including a discussion of methodological issues and task design, comparisons between fMRI and the intracarotid sodium amobarbital test, fMRI studies of language reorganization, and the use of fMRI laterality indexes to predict outcome after anterior temporal lobectomy.

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Comparison of Functional Magnetic Resonance Imaging for Language Localization and Intracarotid Speech Amytal Testing in Presurgical Evaluation for Intractable Epilepsy

Cited by 66 publications

References 0 publications

Functional Imaging of the Auditory System: The Use of Positron Emission Tomography

Functional Imaging of the Auditory System: The Use of Positron Emission Tomography

Comprehensive presurgical functional MRI language evaluation in adult patients with epilepsy

Functional Magnetic Resonance Imaging of Language in Epilepsy

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