Comparison of foveal optical coherence tomography angiography findings between premature children with ROP and non-premature healthy children

Vural, Aslı; Günay, Murat; Çelik, Gökhan; Demirayak, Bengi; Kizilay, Osman

doi:10.1038/s41433-020-01161-x

Cited by 10 publications

(16 citation statements)

References 31 publications

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“…The CFT of ROP children was higher than that of age matched healthy children in our study. What's more, our study con rmed that a smaller FAZ was signi cantly correlated with a thicker CFT, which was consistent with the ndings from Asli Vural et al, who also reported that FAZ was negatively correlated with CFT (r=-0.27, p = 0.03) 30 34 . FAZ is prerequisite for formation of a fovea pit.…”

Section: Resultssupporting

confidence: 92%

“…Besides the area of FAZ, we also found that the mean VD-SCP (foveal) and VD-DCP (foveal) in the group A, B, C were higher than those in the group D. Although there was no signi cant difference between the four groups, the relative trend existed. ROP regardless of treatment options 30 . In the present study, we speculated that the difference in signi cance came from the relatively small sample size.…”

Section: Resultsmentioning

confidence: 99%

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The analysis of foveal microvascular anomalies in retinopathy of prematurity after anti-vascular endothelial growth factor therapy on optical coherence tomography angiography

Liu¹,

Guo²,

Cai³

et al. 2022

Preprint

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Purpose To investigate the quantitative vascular or structural differences in the foveal section of the eyes in ROP children and healthy children using optical coherence tomography angiography (OCTA).Methods This cross-sectional observational comparative study consisted of 75 eyes (44 subjects). Subjects were divided into 4 groups based on the diagnosis or treatment: diagnosed with ROP and treated by intravitreal injection of Conbercept, or Ranibizumab, lesions spontaneously regressed, and healthy age-matched term-born children. Central foveal thickness (CFT), foveal avascular zone (FAZ), superficial/deep capillary plexus (SCP/DCP), and choroidal vessel density (VD) at the foveal section were collected by spectral-domain OCT and OCTA. Correlations between foveal microvasculature, preterm status and visual acuity were also evaluated.Results There were significant differences between the four groups in the FAZ area, CFT, VD-SCP (whole-image), and VD-SCP (parafoveal). The FAZ area of ROP children was significantly smaller than that in age-matched term-born healthy children (p=0.009). The CFT of group Conbercept was considerably lower than that of the group Ranibizumab (p=0.044). The FAZ area showed a positive correlation with choroid VD (p=0.012) and a negative correlation with CFT, VD-SCP (foveal), and VD-DCP (foveal)(p<0.001, p<0.001, p=0.001), whilst the CFT was positively correlated with VD-SCP (foveal) and VD-DCP (foveal)(p=0.003, p=0.001).Conclusion ROP children possess a smaller FAZ area, of which no significant difference is noted when comparing different anti-VEGF agents employed. Anti-VEGF treatment could reduce the CFT, and Conbercept had a better performance than Ranibizumab. Correlation between the microvascular anomalies and central foveal thickness also exists.

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

The analysis of foveal microvascular anomalies in retinopathy of prematurity after anti-vascular endothelial growth factor therapy on optical coherence tomography angiography

Liu¹,

Guo²,

Cai³

et al. 2022

Preprint

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“…In addition to FAZ, foveal VD has also been compared between ROP patients and healthy controls. Many studies have demonstrated an increased foveal VD in the SCP and DCP among ROP patients compared to healthy controls (Kılıçarslan et al, 2023;Liang et al, 2021;Mataftsi et al, 2021;Vural et al, 2021). In contrast, Nonobe et al found no difference in foveal VD and a significantly decreased parafoveal VD, while Rezar-Dreindl et al found no significant difference in VD in both the SCP and DCP among ROP patients compared to healthy controls (Nonobe et al, 2019;Rezar-Dreindl et al, 2021).…”

Section: Rop Versus Healthy Controlsmentioning

confidence: 99%

“…Many studies have investigated the differences in OCTA parameters among patients with a history of laser-treated ROP and spontaneously regressed ROP. One study found no significant difference in OCTA parameters, including FAZ area and foveal and parafoveal VD in both the SCP and DCP, between the eyes of children with asymmetric involvement of ROP who had laser treatment in one eye and spontaneously regressed ROP in the fellow eye (Vural et al, 2021). A further study comparing ROP patients who required laser treatment and ROP patients without treatment found no difference between the groups in any measured OCTA parameter, including FAZ area and whole VD, foveal VD and parafoveal VD in both the SCP and DCP (Czeszyk et al, 2022).…”

Section: Laser Photocoagulationmentioning

confidence: 99%

Vascular imaging findings in retinopathy of prematurity

Rowe,

Belamkar,

Antman

et al. 2023

Acta Ophthalmologica

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Retinopathy of prematurity (ROP) is a vascular disease among preterm infants involving incomplete or abnormal retinal vascularization and is a leading cause of preventable blindness globally. Measurements of ocular blood flow originating from a variety of imaging modalities, including colour Doppler imaging (CDI), fluorescein angiography (FA) and ocular coherence tomography angiography (OCTA), have been associated with changes in ROP patients. Herein, we discuss and summarize the relevant current literature on vascular imaging and ROP reviewed through December 2022. Differences in vascular imaging parameters between ROP patients and healthy controls are reviewed and summarized. The available data identify significantly increased peak systolic velocity (PSV) in the central retinal artery and ophthalmic artery as measured by CDI, increased vascular tortuosity as measured by FA, smaller foveal avascular zone (FAZ) as measured by FA and OCTA, and increased foveal vessel density (VD) and reduced parafoveal VD as measured by OCTA in ROP patients compared with controls. None of the above findings appear to reliably correlate with visual acuity. The studies currently available, however, are inconclusive and lack robust longitudinal data. Vascular imaging demonstrates the potential to aid in the diagnosis, management and monitoring of ROP, alongside retinal examination via indirect ophthalmoscopy and fundus photography.

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“…[ 54 55 56 57 58 ] Several studies have also demonstrated an association between a smaller FAZ and decreased visual acuity and lower gestational age and birth weight. [ 59 60 ] The reason for a smaller FAZ is not fully understood, but an increase in the intraocular VEGF level during the FAZ formation period in ROP may contribute to excessive vasculature, leading to smaller FAZ. One study reported that laser-treated patients had significantly larger FAZs than patients with spontaneously regressed ROP.…”

Section: Ultimodal I Maging In O ...mentioning

confidence: 99%