Comparison of four serum tumour markers in the diagnosis of colorectal carcinoma

Schouw, Yvonne T. van der; Verbeek, A.L.M.; Wobbes, Theo; Segers, M. F. G.; Thomas, C.

doi:10.1038/bjc.1992.233

Cited by 56 publications

(30 citation statements)

References 26 publications

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“…For CRC, CA 19-9 levels add little clinically useful information to determine CEA levels [5]. The low diagnostic power of CA 19-9 may be due to a high proportion of colorectal cancer patients having the Lewis (a-b-) phenotype, who cannot synthesize these markers [6]. The overall reported incidences of high pre-CA 19-9 range from 10.6% to 24.4% [7-11].…”

Section: Discussionmentioning

confidence: 99%

The clinical significance of preoperative serum levels of carbohydrate antigen 19-9 in colorectal cancer

Son

Joh

2013

J Korean Surg Soc

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PurposeCarcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) are the most frequently used tumor markers in the clinical setting of colorectal cancer (CRC). This study was designed to investigate the correlation between preoperative serum levels of CA 19-9 (pre-CA 19-9) and the clinicopathologic factors of patients with CRC.MethodsA study was performed on 333 patients with histologically diagnosed colorectal adenocarcinoma between December 2008 and November 2011, based on prospective collected data. The clinical data such as age, sex, location of tumor, size of tumor, differentiation, depth of tumor (T), lymph node metastasis (N), distant metastasis (M), lymphatic invasion, venous invasion, perineural invasion, stage, and preoperative serum levels of CEA (pre-CEA) and pre-CA 19-9 were obtained. These patients were classified into two groups according to pre-CA 19-9 (CA 19-9 high: >39 U/mL, n = 61 [18.3%]; CA 19-9 normal: <39 U/mL, n = 272 [81.7%]).ResultsSixty-one patients among 333 patients (18.3%) with CRC showed a high pre-CA 19-9. The elevation of pre-CA 19-9 was significantly associated with size of tumor (4.8 ± 0.1 cm vs. 6.1 ± 0.3 cm, P < 0.001), right colon cancer (P < 0.001), depth of tumor (P < 0.001), lymph node metastasis (P < 0.001), distant metastasis (P < 0.001), perineural invasion (P = 0.008), peritoneal seeding (P < 0.001), and stage (P < 0.001). On multivariate analysis, high pre-CA 19-9 was shown to be independently associated with high pre-CEA, lymph node metastasis, right colon cancer, large tumor size, and peritoneal seeding. There were twelve patients confirmed for peritoneal seeding among 333 patients (3.6%).ConclusionHigh pre-CA 19-9 in advanced colorectal cancer might provide important information to predict the possibility of peritoneal seeding.

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Section: Discussionmentioning

confidence: 99%

The clinical significance of preoperative serum levels of carbohydrate antigen 19-9 in colorectal cancer

Son

Joh

2013

J Korean Surg Soc

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“…Its sensitivity and specificity for the diagnosis of this neoplasia have been widely described [2, 3]. However, it is not recommended to be employed alone as a screening or diagnostic test for colorectal cancer [4], and it has been used combined with other tumor markers [5].…”

Section: Introductionmentioning

confidence: 99%

Value of the Serum Alpha-<i>L</i>-Fucosidase Activity in the Diagnosis of Colorectal Cancer

et al. 2000

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Objectives: The purpose of this study was to assess the value of the serum levels of α-L-fucosidase activity in the diagnosis of patients with colorectal cancer. Methods: Using a fluorometric method we analyzed the α-L-fucosidase activity in preoperative sera from 137 colorectal cancer patients and in sera from 232 donors. Results: The enzymatic activity of α-L-fucosidase was significantly lower (p < 0.001) in patients (4.8 ± 3.09 U/ml) than in donors (10.5 ± 5.46 U/ml). Using the ROC curve, the ideal cut-off for the diagnostic value of α-L-fucosidase activity was determined to be 5.6 U/ml. The diagnostic efficiency for colorectal cancer of α-L-fucosidase activity was higher than that observed for carcinoembryonic antigen (cut-off 5.0 ng/ml), especially for tumors at an early stage. Conclusions: Our results suggest that preoperative serum α-L-fucosidase activity may be used as a cheap and easy complementary test, in addition to standard clinical procedures routinely used for the diagnosis of colorectal cancer.

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“…Although a variety of serum tumor markers including CEA, CA 19-9, and CA 125 has been applied to the detection of CRC [1,2], serum levels of such markers are not increased in the early stages of CRC. CA 19-9 is a cancerassociated carbohydrate antigen that plays a critical role in tumor progression as an adhesion molecule; however, CA 19-9 is less sensitive than CEA, which is currently regarded as the best reliable serum marker for CRC.…”

Section: Discussionmentioning

confidence: 99%

Elevated Carbohydrate Antigen 19-9 Caused by Early Colon Cancer Treated with Endoscopic Mucosal Resection

et al. 2007

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Comparison of four serum tumour markers in the diagnosis of colorectal carcinoma

Cited by 56 publications

References 26 publications

The clinical significance of preoperative serum levels of carbohydrate antigen 19-9 in colorectal cancer

The clinical significance of preoperative serum levels of carbohydrate antigen 19-9 in colorectal cancer

Value of the Serum Alpha-<i>L</i>-Fucosidase Activity in the Diagnosis of Colorectal Cancer

Elevated Carbohydrate Antigen 19-9 Caused by Early Colon Cancer Treated with Endoscopic Mucosal Resection

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