Comparison of four radiofrequency ablation systems at two target volumes in an ex vivo bovine liver model

Rathke, Hendrik; Hamm, Bernd; Güttler, Felix; Rathke, Joern; Rump, Jens; Teichgräber, U; Bucourt, M. de

doi:10.5152/dir.2013.13157

Cited by 27 publications

(27 citation statements)

References 19 publications

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“…The rectangular shape of the ablation closely matched the rectangular shape of the volume in between the active parts of the 2 Â 2 electrodes. Variability of ablation size, expressed either as standard deviation (SD) or as coefficient of variation ¼ standard deviation/mean diameter (CV), was limited and smaller than for many currently available electrodes, both in the axial and the transverse plane [33] (Table 1).…”

Section: Variabilitymentioning

confidence: 99%

“…Variability of ablation size obtained with any RF electrode (system) including ours seems to be profoundly inevitable due to biological variability of tissue, even in the most standardised ex vivo experiment [33] (Table 1). The currently presented bipolar 2 Â 2 electrode system tries to circumvent this serious problem by focusing on obtaining a reliable complete ablation within the mechanically imposed boundaries of the 2 Â 2 electrodes.…”

Section: Variabilitymentioning

confidence: 99%

“…In summary, four simple electrodes (Kirschner wires, Devroe Table 1. Variability of ablation size with commercial RF electrodes in ex vivo bovine liver [33]. Matrix radiofrequency ablation.…”

Section: Experimental Set-up and Measurement Of Lesion Sizementioning

confidence: 99%

“…With current electrodes, large ablation zones can be obtained but their predictability and completeness is problematic. Size and shape of the ablation zone are highly variable and difficult to predict [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] even in the most standardised ex vivo experiments (Table 1). A standard deviation of the ablation diameter, especially the transverse diameter, of 0.5-1 cm is very common (Table 1).…”

Section: Introductionmentioning

confidence: 99%

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Bipolar radiofrequency ablation with 2 × 2 electrodes as a building block for matrix radiofrequency ablation:Ex vivoliver experiments and finite element method modelling

Mulier

Jiang

Jamart

et al. 2015

International Journal of Hyperthermia

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Purpose: Size and geometry of the ablation zone obtained by currently available radiofrequency (RF) electrodes is highly variable. Reliability might be improved by matrix radiofrequency ablation (MRFA), in which the whole tumour volume is contained within a cage of x Â y parallel electrodes. The aim of this study was to optimise the smallest building block for matrix radiofrequency ablation: a recently developed bipolar 2 Â 2 electrode system. Materials and methods: In ex vivo bovine liver, the parameters of the experimental set-up were changed one by one. In a second step, a finite element method (FEM) modelling of the experiment was performed to better understand the experimental findings. Results:The optimal power to obtain complete ablation in the shortest time was 50-60 W. Performing an ablation until impedance rise was superior to ablation for a fixed duration. Increasing electrode diameter improved completeness of ablation due to lower temperature along the electrodes. A chessboard pattern of electrode polarity was inferior to a row pattern due to an electric field void in between the electrodes. Variability of ablation size was limited. The FEM correctly simulated and explained the findings in ex vivo liver. Conclusions: These experiments and FEM modelling allowed a better insight in the factors influencing the ablation zone in a bipolar 2 Â 2 electrode RF system. With optimal parameters, complete ablation was obtained quickly and with limited variability. This knowledge will be useful to build a larger system with x Â y electrodes for MRFA.

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Section: Variabilitymentioning

confidence: 99%

Section: Variabilitymentioning

confidence: 99%

Section: Experimental Set-up and Measurement Of Lesion Sizementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bipolar radiofrequency ablation with 2 × 2 electrodes as a building block for matrix radiofrequency ablation:Ex vivoliver experiments and finite element method modelling

Mulier

Jiang

Jamart

et al. 2015

International Journal of Hyperthermia

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“…Radiofrequency ablation (RFA) is an important and minimal-invasive treatment option for hepatic tumors and metastases [1][2][3][4][5][6][7]. It belongs to the energy-based ablation modalities and relies on proper needle electrode placement into the tumor via an open, laparoscopic or percutaneous approach.…”

Section: Introductionmentioning

confidence: 99%

Characterization of benign periablational enhancement following multipolar radiofrequency ablation using perfusion CT in an in-vivo porcine liver model

Vahldiek

Thieme

Gemeinhardt

et al. 2017

JCB

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Abstract. PURPOSE:Thermal ablation is an important interventional option in the management of liver tumors. Immediate postablational imaging regularly shows periablational enhancement. This peripheral hyperperfusion may induce heat-sink effects which could contribute to incomplete tumor ablation. To reduce the effect of hyperperfusion the feeding vessels source must be known. The aim of this study was to dynamically characterize the type of blood supply of the periablational enhancement zone immediately after hepatic radiofrequency ablation (RFA) using perfusion CT. METHODS:We used an in-vivo porcine liver model. Multipolar RFA was performed in healthy pig livers. Immediate postablational perfusion CT was acquired. The contrast enhancement over time of the peripheral ablation zone, the aorta and the portal vein were recorded. Time differences of the peak periablational enhancement to the peak arterial perfusion and to the peak portalvenous perfusion were calculated and analyzed. RESULTS: The perfusion peak of the periablational enhancement zone always occurred in mean 8.1 s after the arterial peak in the aorta and in mean 16.9 s before the peak in the portal vein. CONCLUSIONS: Benign periablational enhancement is a result of primary arterial and not portalvenous hyperperfusion. In order to reduce heat sink effects, peri-ablational arterial balloon occlusion or transarterial chemoembolization may be beneficial during RFA.

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Ablative Options for Renal Cell Carcinoma

Kominsky,

Cadeddu

2023

Integrating Multidisciplinary Treatment for Advanced Renal Cell Carcinoma

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Comparison of four radiofrequency ablation systems at two target volumes in an ex vivo bovine liver model

Cited by 27 publications

References 19 publications

Bipolar radiofrequency ablation with 2 × 2 electrodes as a building block for matrix radiofrequency ablation:Ex vivoliver experiments and finite element method modelling

Bipolar radiofrequency ablation with 2 × 2 electrodes as a building block for matrix radiofrequency ablation:Ex vivoliver experiments and finite element method modelling

Characterization of benign periablational enhancement following multipolar radiofrequency ablation using perfusion CT in an in-vivo porcine liver model

Ablative Options for Renal Cell Carcinoma

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