Comparison of fluticasone propionate and beclomethasone dipropionate on direct and indirect measurements of bronchial hyperresponsiveness in patients with stable asthma.

Abstract

Background -Fluticasone propionate is

Effects of inhaled corticosteroids on bone

“…2, showing the advantage of ICS. However, when looking at comparative trials between FP in half the dose of BDP, being clinically equipotent [41,42], osteocalcin levels were significantly lowered after the double dose of BDP, with no change after FP [31,43]. Ayres et al [44] compared FP with BUD, but all patients already used 1-2 mg of ICS daily before the study.…”

Comparative assessment of safety and efficacy of inhaled corticosteroids: report of a committee of the Canadian Thoracic Society

“…For instance, let us consider the difference in forced expiratory volume in one second (FEV1) following a randomized double-blind crossover trial of inhaled fluticasone propionate versus beclomethasone dipropionate in 21 asthmatic patients [54]. After the two 6 week treatment periods, the difference was 60 mL favouring fluticasone propionate.…”

“…The drugs were, however, sometimes administered by different inhaler devices or without a washout period, making the comparative efficacy of the two agents difficult to assess. [50][51][52][53][54][55]. A 2:1 equivalence of fluticasone over beclomethasone has been suggested, based on the observation of maintenance of the same degree of asthma control with a half-dose of fluticasone compared to beclomethasone [56,57].…”

Comparison of Systemic and Pulmonary Bioavailability of Fluticasone Propionate HFA pMDI 250 Mcg per Actuation With and Without Spacer Device in Healthy Volunteers

“…It is also highly effective in decreasing airway hyper responsiveness [4,6]. It is widely used for the treatment of chronic asthma worldwide [7][8][9][10].…”

“…Pathophysiologically, asthma is characterized by variable airway obstruction that is associated with an exaggerated response to various broncho-constrictor stimuli [1]. Airway inflammation is associated with airway hyper responsiveness, and several studies have shown that inhaled corticosteroids gradually reduce airway hyper responsiveness, possibly by their anti-inflammatory action [2][3][4][5].…”