Comparison of fleroxacin and penicillin G plus probenecid in the treatment of acute uncomplicated gonococcal infections.

Lassus, A; Filho, L Abath; Júnior, Mário Flamini; Belli, Laura

doi:10.1136/sti.68.5.317

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…O'Mahonyf describes treatment failure following 2 oral doses of 500 mg each of ciprofloxacin, when the MlC of ciprofloxacin for the organism was 0.6 mg/l. Other quinolone antibiotics have also been assessed in the treatment of gonorrhoea and results indicate that a single oral dose regimens of 800mg of pefloxacin 45 and 400mg of fleroxacin 46 were effective in uncomplicated gonococcal infections. Satisfactory results were also reported for ofloxacin (single oral dose of 400 mg) and norfloxacin (single oral dose of 800 mg)47, but these and other authors express concern about the emergence of quinolone resistance 45 • 48 .4 9.…”

Section: Gonorrhoeamentioning

confidence: 99%

Antibiotic Chemotherapy of Bacterial Sexually Transmitted Diseases in Adults: A Review

Corcoran

Ridgway

1994

Int J STD AIDS

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Treatment regimens for sexually transmitted infections continue to evolve. The natural history of syphilis in HIV-infected patients is leading to more aggressive policies in terms of both investigation and treatment. In particular, treatment protocols for late syphilis, especially neurosyphilis, are under scrutiny. Epidemiological change typified by the spread of penicillinase-producing Neisseria gonorrhoeae (PPNG) has led to a search for new agents to treat gonorrhoea, with a more extensive use of cephalosporin and quinolone antibiotics emerging. The problem of compliance with the antibiotic courses presently required for chlamydial infection may be close to being solved with the development of newer macrolide agents. Single dose azithromycin, although expensive, seems to be as effective as longer courses with other agents. Furthermore, its efficacy in gonococcal infection is also encouraging. Increased understanding of the pathogenesis and natural history of pelvic inflammatory disease (PID) and bacterial vaginosis (BV) has led to rationalization of treatment policies for these conditions.

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Section: Gonorrhoeamentioning

confidence: 99%

Antibiotic Chemotherapy of Bacterial Sexually Transmitted Diseases in Adults: A Review

Corcoran

Ridgway

1994

Int J STD AIDS

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Drugs of Choice for the Treatment of Uncomplicated Gonococcal Infections

Moran

Levine

1995

Clinical Infectious Diseases

171

124

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Resistance of Neisseria gonorrhoeae to antimicrobial agents continues to spread and intensify. Choosing an antimicrobial regimen requires knowledge of the comparative efficacy of candidate regimens, as delineated in properly conducted clinical trials; their activity against N. gonorrhoeae in vitro; and their pharmacokinetics and toxicity. We tabulated the results of trials of single-dose antimicrobial therapy for uncomplicated gonococcal infection published after 1980. Thirty regimens comprising 21 antimicrobial drugs have been shown to be highly effective for rectal and urogenital infections; the agents involved are cefixime, cefodizime, cefotaxime, cefoxitin, ceftizoxime, ceftriaxone, cefuroxime, cefuroxime axetil, ciprofloxacin, fleroxacin, norfloxacin, ofloxacin, pefloxacin, temafloxacin, azithromycin, aztreonam, netilmicin, rifampin plus erythromycin stearate, sisomicin, and spectinomycin. Few regimens have been shown to be highly effective against pharyngeal infections. Among those antimicrobial agents available for the treatment of uncomplicated gonococcal infections in the United States, ceftriaxone (125 mg), cefixime (400 mg), ciprofloxacin (500 mg), and ofloxacin (400 mg) appear to offer the best balance of proven efficacy and safety.

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Treating Uncomplicated Neisseria gonorrhoeae Infections

Moran

1995

Sexually Transmitted Diseases

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Comparison of fleroxacin and penicillin G plus probenecid in the treatment of acute uncomplicated gonococcal infections.

Cited by 4 publications

References 13 publications

Antibiotic Chemotherapy of Bacterial Sexually Transmitted Diseases in Adults: A Review

Antibiotic Chemotherapy of Bacterial Sexually Transmitted Diseases in Adults: A Review

Drugs of Choice for the Treatment of Uncomplicated Gonococcal Infections

Treating Uncomplicated Neisseria gonorrhoeae Infections

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