1982
DOI: 10.1002/art.1780251003
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COMPARISON of five assays for immune complexes in the RHEUMATIC DISEASES. An Assessment of Their Validity for Rheumatoid Arthritis

Abstract: Clinical assessment (disease activity, severity, and extraarticular manifestations) of 101 rheumatoid arthritis patients was correlated with several laboratory tests, including 5 immune complex assays: the bovine conglutinin, 125I–C1q binding, monoclonal rheumatoid factor inhibition, Raji cell, and staphylococci binding assays. Elevated disease activity indices were most closely associated with the presence of immune complexes detected by the 125I–C1q and staphylococci binding assays. There were significant bu… Show more

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Cited by 37 publications
(13 citation statements)
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“…I' Significantly increased compared with IgMK (P < 0.05). a prolonged exposure to circulating immune complexes (28), which are also present in many RA patients (29).…”
Section: Resultsmentioning
confidence: 99%
“…I' Significantly increased compared with IgMK (P < 0.05). a prolonged exposure to circulating immune complexes (28), which are also present in many RA patients (29).…”
Section: Resultsmentioning
confidence: 99%
“…In contrast, Espinoza and coworkers (8) found 94% positive cases by the use of the same method as Papaioannou (6) and showed an obvious correlation with the presence of CIC and disease activity. This discrepancy in results of CIC investigations, which has also been noted in other diseases (24,25). casts doubt on the reliability of different techniques.…”
Section: Discussionmentioning
confidence: 86%
“…In the same time the dependency between the serum levels of the circulating immune complexes (CIC) and the disease activity is not yet completely elucidated (Ruddy and Moxley, 1994). One of the reasons for this problem may be related to the characteristics of the materials detected (McDougal et al, 1982). It is well known that most of the tests used for quantitative assessment of CIC can detect preferentially IC, containing IgG (IgG-CIC).…”
Section: Introductionmentioning
confidence: 99%