Comparison of FIB‐4 index, NAFLD fibrosis score and BARD score for prediction of advanced fibrosis in adult patients with non‐alcoholic fatty liver disease: A meta‐analysis study

Sun, Wenjing; Cui, Hongli; Li, Ning; Wei, Yanling; Lai, Shujie; Yang, Yang; Yin, Xinru; Chen, Dongfeng

doi:10.1111/hepr.12647

Cited by 178 publications

(134 citation statements)

References 43 publications

Supporting

Mentioning

119

Contrasting

Unclassified

Order By: Relevance

“…In addition to simple bedside tests, these assessments include nonproprietary indices such as the AAR, APRI, FIB‐4, NFS and BARD and patented methods such as the FibroTest ® and Enhanced Liver Fibrosis (ELF) test ® . Although these tests have been widely used for Caucasian patients with NAFLD, their diagnostic performances in staging fibrosis are debatable, particularly in Asian patients with NAFLD . Therefore, we compared the diagnostic performances of the noninvasive fibrosis tests in Asian patients with biopsy‐proven NAFLD.…”

Section: Discussionmentioning

confidence: 99%

“…Nonalcoholic fatty liver disease is related to metabolic syndrome and impaired glucose tolerance . These metabolic traits and the anthropometric data are incorporated into the NFS formula .…”

Section: Discussionmentioning

confidence: 99%

“…10,11 In addition to simple bedside tests, these assess- Nonalcoholic fatty liver disease is related to metabolic syndrome and impaired glucose tolerance. 35,36 These metabolic traits and the anthropometric data are incorporated into the NFS formula. 19 In the current study, FIB-4 and NFS showed good diagnostic performances in predicting advanced fibrosis.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Steatosis severity affects the diagnostic performances of noninvasive fibrosis tests in nonalcoholic fatty liver disease

Joo

Kim

et al. 2017

Liver International

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Steatosis severity affects the diagnostic performances of noninvasive fibrosis tests in nonalcoholic fatty liver disease

Joo

Kim

et al. 2017

Liver International

View full text Add to dashboard Cite

show abstract

“…A recent meta-analysis evaluating the use of FIB-4 index described a pooled sensitivity of 84% and specificity of 69% for diagnosing NAFLD-related advanced fibrosis [43] . However, there have been no previous reports on the usefulness of clinical parameters including FIB-4 index for the diagnosis of NASH with mild fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Ability of Cytokeratin-18 Fragments and FIB-4 Index to Diagnose Overall and Mild Fibrosis Nonalcoholic Steatohepatitis in Japanese Nonalcoholic Fatty Liver Disease Patients

Kobayashi

Kumada

Toyoda

et al. 2017

Dig Dis

View full text Add to dashboard Cite

Background: Several laboratory markers used in lieu of liver biopsy are reportedly useful in the diagnosis of nonalcoholic steatohepatitis (NASH). In the present study, we investigated the diagnostic impact of various non-invasive markers for predicting NASH. Methods: A total of 229 nonalcoholic fatty liver disease (NAFLD) patients who underwent liver biopsy were enrolled for the study. The diagnostic ability of various markers to diagnose NASH from NAFLD was investigated. Results: A total of 140 patients were histologically diagnosed with NASH. Of these, 104 had degree 0-2 fibrosis (F0-2), and 36 had degree 3-4 fibrosis (F3-4). Multiple logistic regression analysis identified hyaluronic acid (HA) (OR 1.014; 95% CI 1.002-1.026; p = 0.024), FIB-4 index (OR 2.097; 95% CI 1.177-3.735; p = 0.012), and cytokeratin-18 fragments (CK-18F) (OR 1.002; 95% CI 1.001-1.002; p < 0.001) as factors independently associated with the diagnosis of NASH. The areas under the receiver operating characteristic curves (AUROCs) of HA, FIB-4 index, and CK-18F for the diagnosis of NASH were 0.77, 0.76, and 0.72, respectively. In addition, FIB-4 index (OR 1.907; 95% CI 1.063-3.419; p = 0.03) and CK-18F (OR 1.002; 95% CI 1.001-1.002; p < 0.001) could differentiate between NASH and NAFL, even when NASH patients with advanced fibrosis (F3-4) were excluded. AUROCs of FIB-4 index and CK-18F for the diagnosis of NASH with mild fibrosis (F0-2) from NAFLD were 0.70 and 0.70, respectively. Conclusions: FIB-4 index and CK-18F have good diagnostic abilities not only for NASH overall, but also for NASH with mild fibrosis.

show abstract

“…Simple and reliable noninvasive tools have been documented in recent years for screening NAFLD [46, 47]. It has been demonstrated that the FIB-4 score based on several laboratory tests can reliably predict advanced fibrosis and cirrhosis in NAFLD [48].…”

Section: Discussionmentioning

confidence: 99%

Association Between Urinary Alpha1-Microglobulin Levels and Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study

Zhang

Zhao

et al. 2017

Ann Nutr Metab

View full text Add to dashboard Cite

Background: We aimed to explore the association between urinary alpha₁-microglobulin (A1M) levels and nonalcoholic fatty liver disease (NAFLD) in a Chinese population. Study: We performed a cross-sectional study among 2,215 Chinese who attended their annual health examination at First Affiliated Hospital, College of Medicine, Zhejiang University. Urinary A1M-creatinine ratio and other clinical and laboratory parameters were measured. Results: A total of 20.9% of subjects fulfilled the diagnostic criteria of NAFLD. NAFLD subjects had significantly higher urinary A1M-creatinine ratios. These levels were positively associated with NAFLD prevalence. The association between A1M-creatinine ratio and NAFLD was independent of hyperglycemia status. Stepwise regression showed that urinary A1M-creatinine ratio was significantly associated with the risk for NAFLD. Urinary A1M-creatinine ratio was an independent factor predicting advanced fibrosis (FIB-4 ≥1.3) in NAFLD patients. Conclusions: Our results showed a significant association between urinary A1M-creatinine ratio and NAFLD.

show abstract

Comparison of FIB‐4 index, NAFLD fibrosis score and BARD score for prediction of advanced fibrosis in adult patients with non‐alcoholic fatty liver disease: A meta‐analysis study

Abstract: FIB-4 index with a 1.30 cut-off has better diagnostic accuracy than the FIB-4 index with a 3.25 cut-off, NFS and BARD score, despite showing its limited value for predicting NAFLD-related advanced fibrosis.

Cited by 178 publications

References 43 publications

Steatosis severity affects the diagnostic performances of noninvasive fibrosis tests in nonalcoholic fatty liver disease

Steatosis severity affects the diagnostic performances of noninvasive fibrosis tests in nonalcoholic fatty liver disease

Ability of Cytokeratin-18 Fragments and FIB-4 Index to Diagnose Overall and Mild Fibrosis Nonalcoholic Steatohepatitis in Japanese Nonalcoholic Fatty Liver Disease Patients

Association Between Urinary Alpha1-Microglobulin Levels and Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study

Contact Info

Product

Resources

About