Comparison of ferumoxytol‐based cerebral blood volume estimates using quantitative R<sub>1</sub> and  relaxometry

Rivera‐Rivera, Leonardo A.; Schubert, Tilman; Knobloch, Gesine; Turski, Patrick A.; Wieben, Oliver; Reeder, Scott B.; Johnson, Kevin M.

doi:10.1002/mrm.26975

Cited by 7 publications

(30 citation statements)

References 56 publications

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“…A vessel + tissue phantom was generated by embedding the fractal vascular tree in an image of GM, WM, and CSF with susceptibility values of χ GM = 0.070, χ WM = 0.040, and χ CSF = 0 ppm. The susceptibility values were selected to resemble the estimated large susceptibility differences between tissue and blood vessels after contrast injection …”

Section: Methodsmentioning

confidence: 99%

“…This is a retrospective re‐analysis of data previously acquired for comparison of R 2 *‐ and R 1 ‐based CBV measures . A total of 22 healthy volunteers (age range 20–61 y, mean 32 y, 12 F) were prospectively recruited from an institutional review board (IRB) approved database.…”

Section: Methodsmentioning

confidence: 99%

“…Ferumoxytol offers the advantage of strong T 1 and T 2 * shortening effects at typical doses and clinical field strengths and an exceptionally long intravascular half‐life (12–14 h). This has enabled CBV imaging in the steady state with extended acquisition times, for substantial improvements in resolution and contrast‐to‐noise ratio compared with GBCA …”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have successfully derived CBV estimates after the administration of ferumoxytol utilizing quantitative R 1 (1/ T 1 ) and R 2 * relaxometry . However, as in DCE and DSC, the conversion of T 1 ‐ and T 2 *‐weighted images to contrast agent concentration is sensitive to factors such as water exchange rates, compartmentalization, flow, and vascular architecture.…”

Section: Introductionmentioning

confidence: 99%

“…The changes in magnetic susceptibility were utilized to estimate CBV in GM and WM. Finally, QSM‐based CBV estimates were compared with R 2 *‐based CBV estimates previously investigated . For this study, we hypothesized that QSM‐based CBV estimates using ferumoxytol enhanced MRI were feasible and comparable to R 2 *‐based estimates.…”

Section: Introductionmentioning

confidence: 99%

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Measurements of cerebral blood volume using quantitative susceptibility mapping, R₂* relaxometry, and ferumoxytol‐enhanced MRI

2019

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Ferumoxytol‐enhanced MRI holds potential for the non‐invasive assessment of vascular architecture using estimates of cerebral blood volume (CBV). Ferumoxytol specifically enables steady‐state imaging with extended acquisition times, for substantial improvements in resolution and contrast‐to‐noise ratio. With such data, quantitative susceptibility mapping (QSM) can be used to obtain images of local tissue magnetic susceptibility and hence estimate the increase in blood susceptibility after administration of a contrast agent, which in turn can be correlated to tissue CBV. Here, we explore the use of QSM for CBV estimation and compare it with R2* (1/T2*)‐based results. Institutional review board approval was obtained, and all subjects provided written informed consent. For this prospective study, MR images were acquired on a 3.0 T scanner in 19 healthy subjects using a multiple‐echo T2*‐weighted sequence. Scanning was performed before and after the administration of two doses of ferumoxytol (1 mg FE/kg and 4 mg FE/kg). Different QSM approaches were tested on numerical phantom simulations. Results showed that the accuracy of magnetic susceptibility measurements improved with increasing image resolution and decreasing vascular density. In vivo changes in magnetic susceptibility were measured after the administration of ferumoxytol utilizing QSM, and significantly higher QSM‐based CBV was measured in gray matter compared with white matter. QSM‐ and R2*‐based CBV estimates correlated well, with similar average values, but a larger variance was found in QSM‐based estimates.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Measurements of cerebral blood volume using quantitative susceptibility mapping, R₂* relaxometry, and ferumoxytol‐enhanced MRI

2019

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Evaluation of a motion‐robust 2D chemical shift‐encoded technique for R2* and field map quantification in ferumoxytol‐enhanced MRI of the placenta in pregnant rhesus macaques

Zhu

Reeder

Johnson

et al. 2019

Magnetic Resonance Imaging

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Background 3D chemical shift‐encoded (CSE)‐MRI techniques enable assessment of ferumoxytol concentration but are unreliable in the presence of motion. Purpose To evaluate a motion‐robust 2D‐sequential CSE‐MRI for R2* and B0 mapping in ferumoxytol‐enhanced MRI of the placenta. Study Type Prospective. Animal Model Pregnant rhesus macaques. Field Strength/Sequence 3.0T/CSE‐MRI. Assessment 2D‐sequential CSE‐MRI was compared with 3D respiratory‐gated CSE‐MRI in placental imaging of 11 anesthetized animals at multiple timepoints before and after ferumoxytol administration, and in ferumoxytol phantoms (0 μg/mL–440 μg/mL). Motion artifacts of CSE‐MRI in 10 pregnant women without ferumoxytol administration were assessed retrospectively by three blinded readers (4‐point Likert scale). The repeatability of CSE‐MRI in seven pregnant women was also prospectively studied. Statistical Tests Placental R2* and boundary B0 field measurements (ΔB0) were compared between 2D‐sequential and 3D respiratory‐gated CSE‐MRI using linear regression and Bland–Altman analysis. Results In phantoms, a slope of 0.94 (r2 = 0.99, concordance correlation coefficient ρ = 0.99), and bias of –4.8 s‐1 (limit of agreement [LOA], –41.4 s‐1, +31.8 s‐1) in R2*, and a slope of 1.07 (r2 = 1.00, ρ = 0.99) and bias of 11.4 Hz (LOA –12.0 Hz, +34.8 Hz) in ΔB0 were obtained in 2D CSE‐MRI compared with 3D CSE‐MRI for reference R2* ≤390 s‐1. In animals, a slope of 0.92 (r2 = 0.97, ρ = 0.98) and bias of –2.2 s‐1 (LOA –55.6 s‐1, +51.3 s‐1) in R2*, and a slope of 1.05 (r2 = 0.95, ρ = 0.97) and bias of 0.4 Hz (LOA –9.0 Hz, +9.7 Hz) in ΔB0 were obtained. In humans, motion‐impaired R2* maps in 3D CSE‐MRI (Reader 1: 1.8 ± 0.6, Reader 2: 1.3 ± 0.7, Reader 3: 1.9 ± 0.6), while 2D CSE‐MRI was motion‐free (Reader 1: 2.9 ± 0.3, Reader 2: 3.0 ± 0, Reader 3: 3.0 ± 0). A mean difference of 0.66 s‐1 and coefficient of repeatability of 9.48 s‐1 for placental R2* were observed in the repeated 2D CSE‐MRI. Data Conclusion 2D‐sequential CSE‐MRI provides accurate R2* and B0 measurements in ferumoxytol‐enhanced placental MRI of animals in the presence of respiratory motion, and motion‐robustness in human placental imaging. Level of Evidence: 1 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2020;51:580–592.

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Comparison of Three Ultrasmall, Superparamagnetic Iron Oxide Nanoparticles for MRI at 3.0 T

Colbert

Ming

Pogosyan

et al. 2022

Magnetic Resonance Imaging

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Background The ultrasmall, superparamagnetic iron oxide (USPIO) nanoparticle ferumoxytol has unique applications in cardiac, vascular, and body magnetic resonance imaging (MRI) due to its long intravascular half‐life and suitability as a blood pool agent. However, limited availability and high cost have hindered its clinical adoption. A new ferumoxytol generic, and the emergence of MoldayION as an alternative USPIO, represent opportunities to expand the use of USPIO‐enhanced MRI techniques. Purpose To compare in vitro and in vivo MRI relaxometry and enhancement of Feraheme, generic ferumoxytol, and MoldayION. Study Type Prospective. Animal Model Ten healthy swine and six swine with artificially induced coronary narrowing underwent cardiac MRI. Field Strength/Sequence 3.0 T; T1‐weighted (4D‐MUSIC, 3D‐VIBE, 2D‐MOLLI) and T2‐weighted (2D‐HASTE) sequences pre‐ and post‐contrast. Assessment We compared the MRI relaxometry of Feraheme, generic ferumoxytol, and MoldayION using saline, plasma, and whole blood MRI phantoms with contrast concentrations from 0.26 mM to 2.10 mM. In‐vivo contrast effects on T1‐ and T2‐weighted sequences and fractional intravascular contrast distribution volume in myocardium, liver, and spleen were evaluated. Statistical Tests Analysis of variance and covariance were used for group comparisons. A P value <0.05 was considered statistically significant. Results The r1 relaxivities for Feraheme, generic ferumoxytol, and MoldayION in saline (22 °C) were 7.11 ± 0.13 mM−1 s−1, 8.30 ± 0.29 mM−1 s−1, 8.62 ± 0.16 mM−1 s−1, and the r2 relaxivities were 111.74 ± 3.76 mM−1 s−1, 105.07 ± 2.20 mM−1 s−1, and 109.68 ± 2.56 mM−1 s−1, respectively. The relationship between contrast concentration and longitudinal (R1) and transverse (R2) relaxation rate was highly linear in saline and plasma. The three agents produced similar in vivo contrast effects on T1 and T2 relaxation time‐weighted sequences. Data Conclusion Relative to clinically approved ferumoxytol formulations, MoldayION demonstrates minor differences in in vitro relaxometry and comparable in vivo MRI characteristics. Level of Evidence 2 Technical Efficacy Stage 1

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Comparison of ferumoxytol‐based cerebral blood volume estimates using quantitative R₁ and relaxometry

Abstract: CBV measurements were successfully derived using a combined approach of R and R2* relaxometry. Magn Reson Med 79:3072-3081, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

Cited by 7 publications

References 56 publications

Measurements of cerebral blood volume using quantitative susceptibility mapping, R₂* relaxometry, and ferumoxytol‐enhanced MRI

Measurements of cerebral blood volume using quantitative susceptibility mapping, R₂* relaxometry, and ferumoxytol‐enhanced MRI

Evaluation of a motion‐robust 2D chemical shift‐encoded technique for R2* and field map quantification in ferumoxytol‐enhanced MRI of the placenta in pregnant rhesus macaques

Comparison of Three Ultrasmall, Superparamagnetic Iron Oxide Nanoparticles for MRI at 3.0 T

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Comparison of ferumoxytol‐based cerebral blood volume estimates using quantitative R1 and relaxometry

Abstract: CBV measurements were successfully derived using a combined approach of R and R2* relaxometry. Magn Reson Med 79:3072-3081, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

Cited by 7 publications

References 56 publications

Measurements of cerebral blood volume using quantitative susceptibility mapping, R2* relaxometry, and ferumoxytol‐enhanced MRI

Measurements of cerebral blood volume using quantitative susceptibility mapping, R2* relaxometry, and ferumoxytol‐enhanced MRI

Evaluation of a motion‐robust 2D chemical shift‐encoded technique for R2* and field map quantification in ferumoxytol‐enhanced MRI of the placenta in pregnant rhesus macaques

Comparison of Three Ultrasmall, Superparamagnetic Iron Oxide Nanoparticles for MRI at 3.0 T

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Resources

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Comparison of ferumoxytol‐based cerebral blood volume estimates using quantitative R₁ and relaxometry

Measurements of cerebral blood volume using quantitative susceptibility mapping, R₂* relaxometry, and ferumoxytol‐enhanced MRI

Measurements of cerebral blood volume using quantitative susceptibility mapping, R₂* relaxometry, and ferumoxytol‐enhanced MRI