Comparison of ferrous sulfate and ferrous glycinate chelate for the treatment of iron deficiency anemia in gastrectomized patients

Mimura, Érika C. Mayumi; Breganó, José Wander; Dichi, Jane Bandeira; Gregório, Émerson Pereira; Dichi, Isaías

doi:10.1016/j.nut.2008.03.017

Cited by 51 publications

(19 citation statements)

References 19 publications

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“…This study confirms that without the stomach or esophagus, glycated albumin remains the most accurate test for glucose control[34•]. • Mimura et al[35] assessed the treatment of iron-deficiency anemia in gastrectomized patients. Patients with iron-deficiency anemia after gastrectomy treated with ferrous sulfate had better results in hematologic laboratory parameters than those who used ferrous glycinate chelate.…”

supporting

confidence: 75%

Nutritional Considerations After Gastrectomy and Esophagectomy for Malignancy

Baker

Wooten

Malloy

2011

Curr. Treat. Options in Oncol.

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This article reviews various methods of assessing and managing post-gastrectomy or esophagectomy patients from a nutritional standpoint, by examining recent research focusing on assessment models, components of enteral feeding, timing of feeding, safety of enteral nutrition (EN) vs total parenteral nutrition (TPN), appetite stimulants, alternative treatments, and long-term care. Pre-, peri-, and post-operative nutrition represent a major prognostic indicator in patients undergoing a gastrectomy or esophagectomy for malignant cancer. An accurate initial nutrition assessment to determine risk, followed by close monitoring pre-operatively and early enteral feeding post-operatively, has been shown to have the most beneficial effects. The optimal delivery route for nutrition involves the use of EN with immune enhancing nutrients while avoiding TPN. In practice, TPN is reserved for patients with post-operative complications that delay enteral feeding for an extended time. While megace is commonly used as an appetite stimulant, the hormone ghrelin is another novel, safe, and efficacious treatment to improve appetite, increase by mouth (PO) intake, and minimize loss of weight and lean body mass. Although use of ghrelin is not yet common practice, as more studies are published, we predict that this will become a more common treatment. While complementary and alternative therapies are commonly employed in this patient population, more research needs to be done before incorporation into our mainstay of treatment. Long term, these patients continue to be at nutritional risk and therefore should be followed to optimize weight maintenance and prevent micronutrient deficiencies.

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supporting

confidence: 75%

Nutritional Considerations After Gastrectomy and Esophagectomy for Malignancy

Baker

Wooten

Malloy

2011

Curr. Treat. Options in Oncol.

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“…So iron supplements have been widely used to overcome IDA. Ferrous sulfate (FeSO 4 ), due to the low cost, is the most commonly used iron supplement, but it could cause many gastrointestinal side effects such as abdominal pain, nausea, and diarrhea [8]. In order to solve the problem, ferrous lactate and sodium iron (ш) ethylenediaminetetraacetate was developed, but the relative low absorption in duodenal alkaline environment of these salts was still unable to meet the requirements [9].…”

Section: Introductionmentioning

confidence: 99%

Effects of a Tripeptide Iron on Iron-Deficiency Anemia in Rats

Xiao

Lei

Wang

et al. 2015

Biol Trace Elem Res

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This study aims to investigate the effects of a tripeptide iron (REE-Fe) on iron-deficiency anemia rats. Sprague-Dawley rats were randomly divided into seven groups: a normal control group, an iron-deficiency control group, and iron-deficiency groups treated with ferrous sulfate (FeSO4), ferrous glycinate (Fe-Gly), or REE-Fe at low-, medium-, or high-dose groups. The rats in the iron-deficiency groups were fed on an iron-deficient diet to establish iron-deficiency anemia (IDA) model. After the model established, different iron supplements were given to the rats once a day by intragastric administration for 21 days. The results showed that REE-Fe had effective restorative action returning body weight, organ coefficients, and hematological parameters in IDA rats to normal level. In addition, comparing with FeSO4 or Fe-Gly, high-dose REE-Fe was more effective on improving the levels of renal coefficient, total iron-binding capacity, and transferrin. Furthermore, the liver hepcidin messenger RNA (mRNA) expression in the high-dose group was significantly higher (p < 0.05) than that in the FeSO4 or Fe-Gly group and showed no significant difference (p > 0.05) with the normal control group. The findings suggest that REE-Fe is an effective source of iron supplement for IDA rats and might be exploited as a new iron fortifier.

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“…Another study has compared oral absorption of iron sulfate with iron glycinate in gastrectomized patients, demonstrating a greater absorption of iron sulfate [13]. …”

Section: Discussionmentioning

confidence: 99%

Iron Absorption following a Single Oral Dose of Ferrous Sulfate or Ferric Gluconate in Patients with Gastrectomy

Santarpia

Pagano²,

Cuomo³

et al. 2013

Ann Nutr Metab

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Background: Iron deficiency anemia frequently occurs in gastrectomized patients. Methods: Serum iron levels following the ingestion of a single oral dose of 105 mg elemental iron, taken as ferrous sulfate (FeS) or ferric gluconate (FeG), have been evaluated in 20 gastrectomized patients (and 20 controls). All subjects participated on 2 different test days, 1 month apart: they took a single dose of 105 mg elemental iron as FeS or FeG after a night of fasting. Serum iron concentrations at baseline, 30, 60, 120 and 180 min after the oral dose administration were measured. Results: In patients and controls receiving FeG, serum iron levels did not significantly change. After oral ingestion of FeS, patients' serum iron levels gradually increased. The increase in serum iron levels was 148 and 168% at 120 and 180 min in patients (p < 0.0001 for both evaluations), whilst in controls, it was 216% at 120 min and 234% at 180 min, i.e. significantly higher than in gastrectomized patients (p < 0.001 for both evaluations). Conclusions: In gastrectomized patients, a single oral dose of FeS shows a significant increase in iron serum concentration, albeit lower than in controls. Further studies on a larger sample of patients will be necessary to confirm these results.

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Comparison of ferrous sulfate and ferrous glycinate chelate for the treatment of iron deficiency anemia in gastrectomized patients

Cited by 51 publications

References 19 publications

Nutritional Considerations After Gastrectomy and Esophagectomy for Malignancy

Nutritional Considerations After Gastrectomy and Esophagectomy for Malignancy

Effects of a Tripeptide Iron on Iron-Deficiency Anemia in Rats

Iron Absorption following a Single Oral Dose of Ferrous Sulfate or Ferric Gluconate in Patients with Gastrectomy

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