Comparison of fentanyl and butorphanol for postoperative pain relief with intravenous patient controlled analgesia

Comparative Assessment of Fentanyl and Butorphanol as a Post Operative Analgesic in Patients after Spinal Anaesthesia

“…It was also noted that butorphanol had a relatively lower VAS score at time 3 as opposed to fentanyl. This indicates that butorphanol is capable of reducing the pain better than fentanyl as similar results were seen by Thakore et al [4] Furthermore in our study we also observed that there were around 36.7% of the patients in the butorphanol group needed a rescue analgesic when compared to fentanyl which was 6.7% in contrast to the results obtained by Thakore et al [5] (Figure 6 and Table 2(a,b,c)).…”

“…However the duration of analgesic effect with butorphanol (mean=107.50 min) and fentanyl (mean=116.00 min) was comparable but the difference doesn't hold any statistical significance. A study done by Thakore et al [4] showed that there was an increased demand of fentanyl due to its shorter duration of action when compared to butorphanol [6]. However this change could be due to the patient anaesthetics administered in this study (Figure 4 and 5).…”

“…A pleasant postoperative period plays a vital role in the surgical outcome [4]. Our study tried to determine the comparative efficacy of both these drugs to produce postoperative analgesia.…”

Physicochemical stability of ternary admixtures of butorphanol, ketamine, and droperidol in polyolefin bags for patient-controlled analgesia use

“…Calibration curve was performed by plotting peak areas against drug concentrations. The coefficient of determination (r2) was calculated. Replicate analyses (n=5) of quality control samples at three concentration levels (5.0, 12.5, and 25.0 μg/mL for butorphanol tartrate; 125.0, 250.0, and 500.0 μg/mL for ketamine hydrochloride; 5.0, 7.5, and 12.5 μg/mL for droperidol) were used for determining the precision and accuracy of the assay.…”

“…It is commonly used for the management of cancer, postoperative, gynecologic, and obstetric pain. As with other opioid analgesics, patient-controlled analgesia (PCA) butorphanol tartrate is associated with troublesome side effects such as nausea and/or vomiting, somnolence, and dizziness 1,2. Droperidol is a dopamine D 2 receptor antagonist that has been widely used for the prevention and treatment of postoperative nausea and vomiting (PONV) and analgesic-induced PONV during PCA over several decades 3.…”