Comparison of femtosecond laser-assisted corneal intrastromal xenotransplantation and the allotransplantation in rhesus monkeys

Jin, He; Liu, Liangping; Ding, Hui; He, Miao; Zhang, Chi; Zhong, Xingwu

doi:10.1186/s12886-017-0595-z

Cited by 15 publications

(20 citation statements)

References 38 publications

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“…A lamellar incision was made using the treatment mode of femtosecond laser–assisted LK (VisuMax; Carl Zeiss Meditec, Jena, Germany); we used the surgical parameters described in our previous research. 16 The surgical parameters were as follows: the diameter of the incision was 7.5 mm, and the incision was located at a depth of 320 μm. The next step was myopic correction of −4.00 diopters (69.59 μm thickness) under PRK (Photorefractive Keratectomy type; WaveLight GmbH, Erlangen, Germany).…”

Section: Methodsmentioning

confidence: 99%

“…We used the femtosecond laser parameters described in our previous research. 16 The surgical parameters were as follows: 160 μm cap thickness, 7.8 mm cap diameter, and 7.8 mm lamellar cornea diameter. The surgeon spread the lenticule out, producing a space that resembles a “stromal pocket” inside the corneal stroma.…”

Section: Methodsmentioning

confidence: 99%

“…However, clinical application of this model is limited because of its invasiveness during creation of the intrastromal pocket and poor inlay materials. 15 In a previous study, 16,17 we have shown that there was no implant rejection after autotransplantation or xenotransplantation using a small-incision femtosecond laser–assisted corneal intrastromal implantation procedure in all rhesus monkeys during a 26-month study period. We also found that the modified concave inlay lamellae changed corneal refractive power.…”

mentioning

confidence: 89%

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Small-Incision Femtosecond Laser–Assisted Intracorneal Concave Lenticule Implantation in Patients With Keratoconus

Jin

Liu

et al. 2019

Cornea

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 89%

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Small-Incision Femtosecond Laser–Assisted Intracorneal Concave Lenticule Implantation in Patients With Keratoconus

Jin

Liu

et al. 2019

Cornea

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“…When comparing our first 12 cases with our last 12 cases, spherical equivalence in the last 12 cases were closer to emmetropia, thus demonstrating that the procedure may improve outcomes with more surgeon experience [ 16 , 50 ]. As more patient data is analyzed, software will become more refined with improved adjustments for higher myopia since these patients tend to have undercorrection [ 13 , 14 , 51 ].…”

Section: Discussionmentioning

confidence: 99%

Initial Single-Site Surgical Experience with SMILE: A Comparison of Results to FDA SMILE, and the Earliest and Latest Generation of LASIK

et al. 2018

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IntroductionThe primary objective was to show our initial surgical single-site experience with small incision lenticule extraction (SMILE) after the official enrollment in March 2017 following Food and Drug Administration (FDA) approval for simple myopia in late 2016 in the United States and, subsequently, compare our results to the earliest and most advanced generation of excimer platforms for laser-assisted in situ keratomileusis (LASIK) surgery.MethodsThis was a retrospective single-site study of 68 eyes from 35 patients who had SMILE surgery. The patients’ preoperative and postoperative uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), manifest sphere, manifest cylinder, intraoperative complications, and preoperative and postoperative visual symptoms were collected. We compared our findings to the results from the FDA SMILE study, and to the three earliest (1999–2000) and three of the most updated (2013–2016) platforms for LASIK.ResultsThe cumulative UDVA was 20/20 and 20/40 or better in 74% and 100% of patients, respectively. The intended target refraction was within ± 0.5 and ± 1.00 D in 80% and 93% of cases, respectively. The prevalence of dry eyes decreased by nearly half from 1-week to the 6-month postoperative interval. Patients noted improvement in glare (17%), halos (17%), fluctuation (25%), and depth perception (8%) at the 6-month interval compared to preoperative levels.ConclusionsThis study’s findings are consistent with current SMILE reports. Notably, the results are superior to the earliest generation of LASIK, however inferior to the latest excimer platforms. SMILE does meet the efficacy and safety criteria met by FDA; however, there is a definite need for further improvement to reach the superior refractive outcomes produced by the latest generation of LASIK platforms.

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“…For example, xenotransplantation experiments are classified under the current legislation as “severe” procedures, since they are likely to compromise the general health of the animal in the case of organ rejection. However, NHPs are still presently used in this sort of research [52,53].…”

Section: The Ethical Framework Of Deontology and Utilitarianismmentioning

confidence: 99%

Ethical and Scientific Pitfalls Concerning Laboratory Research with Non-Human Primates, and Possible Solutions

Carvalho

Gaspar

Knight

et al. 2018

Animals

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Simple SummaryLegislation and guidelines governing biomedical research with humans and non-human primates (NHPs) rely on different ethical frameworks. In this paper we argue that the main ethical framework used to assess and justify NHP experimentation is inadequate for its purpose. We propose a change of framework that we believe would benefit NHPs and improve research quality.AbstractBasic and applied laboratory research, whenever intrusive or invasive, presents substantial ethical challenges for ethical committees, be it with human beings or with non-human animals. In this paper we discuss the use of non-human primates (NHPs), mostly as animal models, in laboratory based research. We examine the two ethical frameworks that support current legislation and guidelines: deontology and utilitarianism. While human based research is regulated under deontological principles, guidelines for laboratory animal research rely on utilitarianism. We argue that the utilitarian framework is inadequate for this purpose: on the one hand, it is almost impossible to accurately predict the benefits of a study for all potential stakeholders; and on the other hand, harm inflicted on NHPs (and other animals) used in laboratory research is extensive despite the increasing efforts of ethics committees and the research community to address this. Although deontology and utilitarianism are both valid ethical frameworks, we advocate that a deontological approach is more suitable, since we arguably have moral duties to NHPs. We provide suggestions on how to ensure that research currently conducted in laboratory settings shifts towards approaches that abide by deontological principles. We assert that this would not impede reasonable scientific research.

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Comparison of femtosecond laser-assisted corneal intrastromal xenotransplantation and the allotransplantation in rhesus monkeys

Cited by 15 publications

References 38 publications

Small-Incision Femtosecond Laser–Assisted Intracorneal Concave Lenticule Implantation in Patients With Keratoconus

Small-Incision Femtosecond Laser–Assisted Intracorneal Concave Lenticule Implantation in Patients With Keratoconus

Initial Single-Site Surgical Experience with SMILE: A Comparison of Results to FDA SMILE, and the Earliest and Latest Generation of LASIK

Ethical and Scientific Pitfalls Concerning Laboratory Research with Non-Human Primates, and Possible Solutions

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