Comparison of fasting and postprandial plasma lipoproteins in subjects with and without coronary heart disease

Schaefer, Ernst J.; Audelin, Marie C.; McNamara, Judith; Shah, Paulesh K.; Tayler, Timothy D.; Daly, Jennifer A; Augustín, J; Seman, Leo; Rubenstein, Joel J.

doi:10.1016/s0002-9149(01)02047-1

Cited by 102 publications

(79 citation statements)

References 30 publications

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“…Case-control studies that evaluated the relationship between PPTG levels and CAD used different fat loading protocols in different patient groups and different results were found (17)(18)(19)(20)(21). The follow up period after fat loading is 4 to 24 hours in these trials.…”

Section: Discussionmentioning

confidence: 99%

“…The follow up period after fat loading is 4 to 24 hours in these trials. In some of these studies, a standard test meal similar to ours was used (17,19,20), in others vitamin A fat loading test was used (18,21). In all the studies TG levels increased in patients with and without CAD after fat loading.…”

Section: Discussionmentioning

confidence: 99%

“…Lipid enriched enteral solutions or meals with a high fat and caloric content are used for lipid loading in literature (17)(18)(19)(20)(21). Since it is well tolerated by the patients and easily provided in our country we preferred to give a breakfast rich in lipids.…”

Section: Lipid Loading Protocolmentioning

confidence: 99%

“…Postprandial hypertriglyceridemia, reflecting an elevated concentration of lipoprotein remnant particles, might change atherosclerotic lesion content and might show procoagulant, anti-fibrinolytic and pro-inflammatory effects (7,8). Previously some prospective studies (9)(10)(11)(12)(13)(14)(15)(16) and case-control studies (17)(18)(19)(20)(21) demonstrated a relationship between nonfasting triglyceride levels and cardiovascular disease. These case-control studies used different fat loading protocols in different patient groups and conflicting results were found.…”

Section: Introductionmentioning

confidence: 99%

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Is there any relationship between coronary artery disease and postprandial triglyceride levels?

Atar¹,

Atar²,

Aydınalp³

et al. 2011

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ÖZETAmaç: Biz bu çalışmada, tokluk trigliserid (TTG) düzeyi ve koroner arter hastalığı (KAH) arasındaki ilişkiyi araştırmayı amaçladık. Yöntemler: Bu prospektif kohort çalışmasına toplam 80 hasta dahil edildi ve TTG düzeyini ölçmek için ağızdan lipit yüklemesi yapıldı. Aç olarak ve lipitten zengin bir kahvaltı sonrası 2., 4., 6. ve 8. saatte tok olarak trigliserid düzeyi enzimatik yöntemle ölçüldü. Açlık trigliserid yüksekliği olan ve olmayan bireylerde lipit yüklemesinin trigliserid düzeyi üzerine etkisinin değerlendirilmesi için alt grup analizi uygulandı. Lipid yüklemesi sonrası trigliserid düzeyleri ve trigliserid düzeyindeki yüzde değişim oranları "tekrarlayan değerler için genel lineer model" analizi ile değerlen-dirildi. Örneklem büyüklüğü hesaplandı. Bulgular: Başlangıçtaki klinik, demografik ve biyokimyasal ölçümlerin sonuçları gruplar arasında benzerdi. Her iki grupta da zirve trigliserid seviyesi lipit yüklemesi sonrası 4. saatteydi. Lipit yüklemesi sonrası her iki grupta da trigliserid düzeyleri başlangıca göre anlamlı olarak arttı (p<0.001) ancak bu değişimler iki grup arasında farklı değildi (p=0.279). Alt grup analizlerinde; açlık trigliserid yüksekliği olan alt grupta, trigliserid düzeyi eğrisi altında kalan alanda KAH grubunda kontrol grubuna göre anlamlı yükseklik vardı (334±103 vs. 233±58 mg/dl, p=0.02). Sonuç: Bizim sonuçlarımız, açlık trigliserid düzeyi yüksek olan hastalarda TTG yüksekliğinin KAH ile ilişkili olabileceğini, ancak açlık trigliserid düzeyi yüksek olmayan hastalarda TTG düzeyi ile KAH arasında bir ilişki olmadığını göstermektedir. ABSTRACTObjective: We aimed to evaluate the relationship between postprandial triglyceride (PPTG) levels and coronary artery disease (CAD). Methods: A total of 80 patients were included in this prospective cohort study. Oral lipid loading was used in order to measure PPTG levels. In the fasting state and after the high fat breakfast, triglyceride levels were measured by enzymatic methods at 2 nd , 4 th , 6 th and 8 th hours. We made subgroup analysis to show the effects of lipid loading on triglyceride levels in patients with and without fasting hypertriglyceridemia. We evaluated triglyceride levels and changes of triglyceride levels in percentages after lipid loading using a general linear model for repeated measures. Sample size analysis was performed. Results: Baseline clinical, demographic and laboratory characteristics of both groups were similar. The peak triglyceride levels were seen at the 4 th hour in both groups. Triglyceride levels were significantly increased after lipid-rich-breakfast loading compared to baseline levels in both groups (p<0.001) but these changes were not significant (p=0.279). In patients with elevated fasting triglyceride levels, the area under the plasma triglyceride concentration curve was significantly larger in CAD group than control group (334±103 vs. 233±58 mg/dl, p=0.02). Conclusion: Our data show that in patients who have a high fasting triglyceride level, high levels of PPTG may be related to CAD, however high...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Lipid Loading Protocolmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Is there any relationship between coronary artery disease and postprandial triglyceride levels?

Atar¹,

Atar²,

Aydınalp³

et al. 2011

Anadolu Kardiyol Derg

View full text Add to dashboard Cite

show abstract

“…Circulating levels of glucose, for example, are tightly regulated by insulin and normally maintained within a narrow range. Not so for fats: levels of plasma triglycerides in chylomicrons can vary 10-fold between fasting and feeding in humans, 5 and even more so in rodents. How does the endothelium handle this sudden surge?…”

Section: Article See P 1289mentioning

confidence: 99%