Comparison of Fast and Slow Bolus Injections of Mivacurium Chloride Under Narcotic-Nitrous Oxide Anesthesia

Cheng, M.; Lee, C.; Yang, E.; Cantley, E.

doi:10.1097/00000542-198809010-00877

Cited by 2 publications

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“…There were no significant cardiovascular effects following the 0.15-mgkg" 1 dose of mivacurium, in contrast with the larger doses, with which significant hypotension was seen in almost 50% of patients. This is consistent with other reports [12,13] and may be related to histamine release [13]. Each episode of hypotension resolved spontaneously and rapidly, and was not considered a problem.…”

Section: Discussionsupporting

confidence: 92%

“…This decrease in arterial pressure may be more significant in patients with compromised cardiovascular function. The incidence of hypotension with the higher doses may be reduced if the mivacurium bolus is administered slowly over 60-75 s [13]. Our data suggest that mivacurium 0.15 mg kg" 1 is as efficacious in producing neuromuscular block as the larger doses used in our study and is less likely to produce hypotension.…”

Section: Discussionmentioning

confidence: 46%

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Comparison of the Neuromuscular Block Induced by Mivacurium, Suxamethonium or Atracurium During Nitrous Oxide-Fentanyl Anaesthesia

Caldwell

Heier

Kitts

et al. 1989

British Journal of Anaesthesia

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We compared the neuromuscular and cardiovascular changes following administration of mivacurium 0.15, 0.20 and 0.25 mg kg-1, suxamethonium 1.0 mg kg-1 or atracurium 0.5 mg kg-1 i.v. in 41 (ASA physical status I or II) patients during nitrous oxide-fentanyl anaesthesia. Mean onset times for total ablation of twitch response for mivacurium 0.15, 0.20 and 0.25 mg kg-1, were 2.5, 2.4 and 2.7 min, respectively, similar to that for atracurium (2.5 min), but longer than for suxamethonium (1.1 min) (P less than 0.05). Mean times from administration of drug until twitch response recovered to 10% of control were shorter for each dose of mivacurium (15.6, 18.0 and 20.6 min, respectively) than for atracurium (40.0 min) and longer than for suxamethonium (7.7 min) (P less than 0.05). Mean infusion rate required to maintain twitch response at 5 +/- 4% control was 6.7 micrograms kg-1 min-1 for mivacurium and 6.3 micrograms kg-1 min-1 for atracurium. Following neostigmine 0.045 mg kg-1, mean times for twitch tension to recover from 10% to 90% of control were similar for mivacurium (9.7 min) and atracurium (10.5 min). Transient decreases in mean arterial pressure (greater than 20%) were observed in seven of 15 patients who received the two higher doses of mivacurium.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 46%