Comparison of Extraction Techniques and Surfactants for the Isolation of Total Polyphenols and Phlorotannins from the Brown Algae <i>Lobophora variegata</i>

Yılmaz, Gülçin Gümüş; Gómez‐Pinchetti, Juan Luis; Cifuentes, Alejandro; Herrero, Miguel

doi:10.1080/00032719.2019.1597878

Cited by 16 publications

(8 citation statements)

References 35 publications

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“…Surfactants can form monomolecular layers on the surface of a liquid, decreasing the interfacial tension between two liquids, allowing the miscibility of two liquid. This could enable SME to be used in the isolation of compounds with a wide range of polarities and complex chemical structures [ 100 ]. Yılmaz et al [ 100 ] have conducted a comparative study of SME with EAE and PLE, for isolation of total phenolic compounds and phlorotannins from brown seaweed Lobophora variegata .…”

Section: Emerging Technologies For Extraction Of Marine Phenolicsmentioning

confidence: 99%

“…This could enable SME to be used in the isolation of compounds with a wide range of polarities and complex chemical structures [ 100 ]. Yılmaz et al [ 100 ] have conducted a comparative study of SME with EAE and PLE, for isolation of total phenolic compounds and phlorotannins from brown seaweed Lobophora variegata . They reported that the yield of both total phenolics and phlorotannins were higher for SME, than EAE and PLE.…”

Section: Emerging Technologies For Extraction Of Marine Phenolicsmentioning

confidence: 99%

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Emerging Technologies for the Extraction of Marine Phenolics: Opportunities and Challenges

2020

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Natural phenolic compounds are important classes of plant, microorganism, and algal secondary metabolites. They have well-documented beneficial biological activities. The marine environment is less explored than other environments but have huge potential for the discovery of new unique compounds with potential applications in, e.g., food, cosmetics, and pharmaceutical industries. To survive in a very harsh and challenging environment, marine organisms like several seaweed (macroalgae) species produce and accumulate several secondary metabolites, including marine phenolics in the cells. Traditionally, these compounds were extracted from their sample matrix using organic solvents. This conventional extraction method had several drawbacks such as a long extraction time, low extraction yield, co-extraction of other compounds, and usage of a huge volume of one or more organic solvents, which consequently results in environmental pollution. To mitigate these drawbacks, newly emerging technologies, such as enzyme-assisted extraction (EAE), microwave-assisted extraction (MAE), ultrasound-assisted extraction (UAE), pressurized liquid extraction (PLE), and supercritical fluid extraction (SFE) have received huge interest from researchers around the world. Therefore, in this review, the most recent and emerging technologies are discussed for the extraction of marine phenolic compounds of interest for their antioxidant and other bioactivity in, e.g., cosmetic and food industry. Moreover, the opportunities and the bottleneck for upscaling of these technologies are also presented.

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Section: Emerging Technologies For Extraction Of Marine Phenolicsmentioning

confidence: 99%

Section: Emerging Technologies For Extraction Of Marine Phenolicsmentioning

confidence: 99%

Emerging Technologies for the Extraction of Marine Phenolics: Opportunities and Challenges

2020

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“…The geometrical structures of phlorotannins (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) and control drugs such as volasertib (16) were optimised by the B3LYP hybrid function with a 6-31 G basis set using the DFT method (Figure 1). DFT is the most commonly used computation based on quantum theory to optimise the electrical structures of isolated atoms or molecules.…”

Section: Structure Optimisation By Dft Studymentioning

confidence: 99%

“…Phlorotannins, abundantly distributed in brown algae, are an important class of polymeric phloroglucinol containing multiple hydroxyl groups, which makes them highly soluble in water. They are polymerised through shikimate pathways via connecting C-C or C-O-C linkages [1]. Based on types of linkages, phlorotannins are divided into different groups such as fucols (phenyl bond), phlorethols (ether bond), fucophlorethols (ether and phenyl bond) eckols, fuhalol, and carmalols (a dibenzo-dioxin bond).…”

Section: Introductionmentioning

confidence: 99%

Pentafuhalol-B, a Phlorotannin from Brown Algae, Strongly Inhibits the PLK-1 Overexpression in Cancer Cells as Revealed by Computational Analysis

Ansari,

Rab,

Saquib

et al. 2023

Molecules

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Polo-like kinase-1 (PLK-1) is an essential mitotic serine/threonine (Ser/Thr) kinase that belongs to the Polo-like kinase (PLK) family and is overexpressed in non-small cell lung cancer (NSCLC) via promotion of cell division. Therefore, PLK-1 may act as a promising target for the therapeutic cure of various cancers. Although a variety of anti-cancer drugs, both synthetic and naturally occurring, such as volasertib, onvansertib, thymoquinone, and quercetin, are available either alone or in combination with other therapies, they have limited efficacy, especially in the advanced stages of cancer. To the best of our knowledge, no anticancer agent has been reported from marine algae or microorganisms to date. Thus, the aim of the present study is a high-throughput virtual screening of phlorotannins, obtained from edible brown algae, using molecular docking and molecular dynamic simulation analysis. Among these, Pentafuhalol-B (PtB) showed the lowest binding energy (best of triplicate runs) against the target protein PLK-1 as compared to the reference drug volasertib. Further, in MD simulation (best of triplicate runs), the PtB-PLK-1 complex displayed stability in an implicit water system through the formation of strong molecular interactions. Additionally, MMGBSA calculation (best of triplicate runs) was also performed to validate the PtB-PLK-1 complex binding affinities and stability. Moreover, the chemical reactivity of PtB towards the PLK-1 target was also optimised using density functional theory (DFT) calculations, which exhibited a lower HOMO-LUMO energy gap. Overall, these studies suggest that PtB binds strongly within the pocket sites of PLK-1 through the formation of a stable complex, and also shows higher chemical reactivity than the reference drug volasertib. The present study demonstrated the inhibitory nature of PtB against the PLK-1 protein, establishing its potential usefulness as a small molecule inhibitor for the treatment of different types of cancer.

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“…23 The carbon to carbon and carbon to oxygen linkages observed due to tautomerization of phloroglucinol have led to various types of phlorotannins. 24…”

Section: Chemical Composition and Properties Of Phlorotanninsmentioning

confidence: 99%

Aquatic Phlorotannins and Human Health: Bioavailability, Toxicity, and Future Prospects

Okeke

Nweze

Chibuogwu

et al. 2021

Natural Product Communications

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Medicinal chemists and pharmacognosists have relied on terrestrial sources for bioactive phytochemicals to manage and treat disease conditions. However, minimal interest is given to sea life, especially macroalgae and their inherent phytochemical reserves. Phlorotannins are a special class of phytochemicals mainly predominant in brown algae of marine and estuarine habitats. Phlorotannins are formed through the polymerization of phloroglucinol residues and derivatives via the polyketide (acetate–malonate) pathway. Studies over the past decades have implicated phlorotannins with several bioactivities, including anti-herbivory, antioxidants, anti-inflammatory, anti-microbial, anti-proliferative, anti-diabetic, radio-protective, adipogenic, anti-allergic, and anti-human immunodeficiency virus (anti-HIV) properties. All these activities are reflected in their applications as nutraceuticals and cosmeceutical agents. This article reviews the chemical composition of phlorotannins, their biological roles, and their applications. Moreover, very few studies on phlorotannin bioavailability, safety, and toxicity have been thoroughly reviewed. The paper concludes by suggesting exciting research questions for further studies.

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Comparison of Extraction Techniques and Surfactants for the Isolation of Total Polyphenols and Phlorotannins from the Brown Algae Lobophora variegata

Cited by 16 publications

References 35 publications

Emerging Technologies for the Extraction of Marine Phenolics: Opportunities and Challenges

Emerging Technologies for the Extraction of Marine Phenolics: Opportunities and Challenges

Pentafuhalol-B, a Phlorotannin from Brown Algae, Strongly Inhibits the PLK-1 Overexpression in Cancer Cells as Revealed by Computational Analysis

Aquatic Phlorotannins and Human Health: Bioavailability, Toxicity, and Future Prospects

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