Comparison of extraction and clean-up methods for comprehensive screening of organic micropollutants in fish using gas chromatography coupled to high-resolution mass spectrometry

Multilayered solid phase extraction and ultra performance liquid chromatographic method for suspect screening of halogenated pharmaceuticals and photo-transformation products in freshwater - comparison between data-dependent and data-independent acquisition mass spectrometry

“…However, in future cases where the analyte concentrations are even lower, improvements for the method could be tested. In order to better the sensitivity and mitigate the ME, an additional sample clean-up step with deactivated or multilayer silica could be attempted [52]. Moreover, a chromatographic run with slower gradient during the elution could ameliorate ME issues at MS 2 detection, since natural organic matter would impact less and more slowly the ionization steps, decreasing signal suppression under these conditions.…”

First Discovery of Iodinated Polyfluoroalkyl Acids by Nontarget Mass-Spectrometric Analysis and Iodine-Specific Screening Algorithm

“…Nontarget analysis has become a practicable and reliable approach for screening and identification of environmental pollutants, which can alleviate the dilemma in lack of reference standards. , By means of state-of-the-art analytical technologies in terms of chromatography and high-resolution mass spectrometry (HRMS), many nontarget analysis methods for environmental pollutants have been developed in recent years. − The advanced technologies employed in nontarget analysis mainly include liquid chromatography-quadrupole-Orbitrap HRMS (LC-Q-Orbitrap-HRMS), − gas chromatography-Q-Orbitrap-HRMS (GC-Q-Orbitrap-HRMS), , LC-quadrupole time-of-flight MS (LC-QTOF-MS), − GC-QTOF-MS, , and Fourier transform ion cyclotron resonance MS (FT-ICR-MS). , In many studies concerning the identification of PFASs, nontarget analysis has also been used, and >1000 previously unrecognized PFASs have been continuously found in various matrices, such as commercial products, ,− environmental matrices, − and biological samples. ,− These nontarget analysis methods mainly utilized LC-Q-Orbitrap-HRMS ,− and LC-QTOF-MS, ,, with data acquisition modes in full scan, , data-dependent acquisition (DDA) and data-independent acquisition (DIA). ,, Characteristic fragment ions such as C 2 F 5 – , C 3 F 5 – , FSO 3 – , HSO 4 – , PO 3 – , and NSO 2 – were used for tracing quasi-molecular ions, , thus identifying PFASs. Moreover, carbon and sulfur isotopologue distributions are also useful features for the screening and identification of PFASs as some previous studies have applied isotopic patterns to facilitating nontarget identification of PFAS pollutants. ,, …”

“…21,22 By means of state-of-the-art analytical technologies in terms of chromatography and high-resolution mass spectrometry (HRMS), many nontarget analysis methods for environmental pollutants have been developed in recent years. 23−26 The advanced technologies employed in nontarget analysis mainly include liquid chromatography-quadrupole-Orbitrap HRMS (LC-Q-Orbitrap-HRMS), 27−31 gas chromatography-Q-Orbitrap-HRMS (GC-Q-Orbitrap-HRMS), 32,33 LC-quadrupole time-of-flight MS (LC-QTOF-MS), 34−36 GC-QTOF-MS, 37,38 and Fourier transform ion cyclotron resonance MS (FT-ICR-MS). 39,40 In many studies concerning the identification of PFASs, nontarget analysis has also been used, and >1000 previously unrecognized PFASs have been continuously found in various matrices, such as commercial products, 2,41−43 environmental matrices, 44−46 and biological samples.…”

Comprehensive characterization of per- and polyfluoroalkyl substances in wastewater by liquid chromatography-mass spectrometry and screening algorithms

“…By virtue of recent advances in chromatography and high-resolution mass spectrometry (HRMS), numerous nontarget and suspect screening analysis methods for environmental pollutants have been rapidly developed [18][19][20][21][22] . The cutting-edge analytical techniques applied in nontarget and suspect screening analyses mainly include liquid chromatography coupled with quadrupole-Orbitrap HRMS (LC-Q-Orbitrap-HRMS) [23][24][25][26][27] , gas chromatography coupled with Q-Orbitrap-HRMS (GC-Q-Orbitrap-HRMS) 28,29 , LC coupled with quadrupole time-of-flight MS (LC-QTOF-MS) [30][31][32] , GC-QTOF-MS 33,34 , Fourier transform ion cyclotron resonance HRMS (FT-ICR-HRMS) 35,36 , etc. Nontarget and suspect analyses have also been applied in the screening and identification of PFASs, and more than 1000 previously unrecognized PFASs have been identified in various matrices recently 37 , e.g., commercial products 1,38,39 , environmental matrices [40][41][42] and biological samples 2,43,44 .…”