Comparison of Extracellular Matrix Antigens in Subtypes of Bronchioloalveolar Carcinoma and Conventional Pulmonary Adenocarcinoma

Np, Ohori; Yang, Sa; Griffin, John P.; Stanis, K; Stetler-Stevenson, William G.; Tv, Colby; Sonmez-Alpan, E

doi:10.1097/00000478-199207000-00006

Cited by 49 publications

(31 citation statements)

References 17 publications

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“…Although several studies of stromal proliferation in lung cancer have been conducted (26,27), association with histopathologic, proliferative, and oncogenic characteristics, as well as the impact of these factors on overall survival, has not previously been considered.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Values of Stromal Proportion and PCNA, Ki-67, and p53 Proteins in Patients with Resected Adenocarcinoma of the Lung

et al. 2000

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Section: Discussionmentioning

confidence: 99%

Prognostic Values of Stromal Proportion and PCNA, Ki-67, and p53 Proteins in Patients with Resected Adenocarcinoma of the Lung

et al. 2000

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“…Our observations are consistent with previous studies in which the basement membrane of the bronchioloalveolar carcinoma was often destroyed. 21,24,26 Our results suggest that noninvasive carcinoma components in mixed adenocarcinoma already express a molecular mechanism involving MMPs similar to that expressed in invasive carcinomas. Destruction of the basement membrane was observed in bronchioloalveolar 27 showed that cancer-induced myofibroblasts are derived from the bone marrow.…”

Section: Discussionmentioning

confidence: 59%

Expression and localization of mRNAs for matrix metalloproteinases and their inhibitors in mixed bronchioloalveolar carcinomas with invasive components

et al. 2005

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Matrix metalloproteinases (MMPs) are believed to play an essential role in cancer invasion, although detailed differences between noninvasive and invasive lung carcinomas are still unclear. To elucidate the expression and activity patterns of MMPs in noninvasive and invasive carcinoma of the lung, we performed in situ hybridization and real-time reverse transcription-polymerase chain reaction to detect messenger RNAs (mRNAs) of MMPs and their tissue inhibitors (TIMPs). The basement membrane was evaluated by immunohistochemistry for type IV collagen. Gelatinase activity was examined by zymography and in situ zymography. A total of 14 surgically resected primary pulmonary adenocarcinomas were used for this study. All the tumors were adenocarcinoma mixed bronchioloalveolar carcinomas according to the 1999 WHO classification. MMP and TIMP2 mRNAs were detected by in situ hybridization in all samples, in both noninvasive and invasive carcinoma components. Signals for MMP mRNAs were significantly higher in both noninvasive and invasive carcinomas than in tumor-free lung tissue. However, the differences were small between noninvasive and invasive carcinomas, not only in the amount of mRNA but also in the activity of the MMPs. In most carcinomas, stromal fibroblast-type cells tended to express levels of MMP and TIMP2 mRNAs that were higher than or at least similar to those expressed in epithelial cells. Our data on mixed adenocarcinoma suggest that noninvasive carcinoma areas already express a molecular mechanism involving MMPs similar to that expressed by invasive carcinoma areas. Stromal fibroblast-type cells seem to be the most important source of MMPs, from the earliest event of tumor invasion by pulmonary adenocarcinomas. Modern Pathology (2005) 18, 828-837, advance online publication, 14 January 2005; doi:10.1038/modpathol.3800365Keywords: bronchioloalveolar carcinoma; in situ hybridization; matrix metalloproteinase Matrix metalloproteinase (MMP) is essential in remodeling the extracellular matrix. The degradation of the extracellular matrix and basement membranes by MMPs is believed to be crucial in tumor invasion. 1,2 Tissue inhibitor of metalloproteinases (TIMPs) were initially recognized as inhibitors of MMPs, as the name implies. However, subsequent studies revealed that TIMP2 also plays an important role in the activation of MMP2. A complex of TIMP2 and MT1-MMP is now known to be a receptor and activator of MMP2. 3 MMP1, MMP2, MMP3, MMP7, MMP9, MMP11, MMP13, MT1-MMP, TIMP1, and TIMP2 have been detected in various histological types of lung carcinomas. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] However, previous studies rarely examined noninvasive carcinomas, and little is known about how MMP expression differs in noninvasive and invasive carcinomas. Immunohistochemical detection of MMP2 in bronchioloalveolar carcinomas has produced a great variety of results. The expression frequency of MMP2 in bronchioloalveolar carcinomas has been reported to range from 17 to 96%. [19][20][21] This might be du...

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“…Although several studies of extracellular matrix proliferation in cancer have been carried out 20,21 the association of these parameters with nuclear changes and oncogenic characteristics in pNTs, as well as the impact of these factors on prognosis have not been previously considered. Although with marginal significance, our data showed that tumors with higher collagen density were at an upper risk for recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…[7][8][9] In addition, as the nuclear and stromal activity of tumor cells have been shown to influence tumor invasion and metastases, specific markers such as AgNOR, [10][11][12] DNA ploidy, [13][14][15] Ki-67, 16,17 p53, 15,16,18 collagen and neuropil matrix components have also been targeted as potential useful tumor markers. 16,[19][20][21][22] To validate the importance of NB84, synaptophysin and AgNOR and to explore the quantitative relationship between these factors and histological diagnosis and prognosis, as well as the relationship between NB84, synaptophysin and AgNOR and other tumor and stromal factors, we studied these markers in peripheral neuroblastic tumors and herein report our results.…”

Section: Introductionmentioning

confidence: 99%

Morphometric Evaluation of Nb84, Synaptophysin and Agnor Is Useful for the Histological Diagnosis and Prognosis in Peripheral Neuroblastic Tumors (Pnts)

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Parra

Zerbini

et al. 2007

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Comparison of Extracellular Matrix Antigens in Subtypes of Bronchioloalveolar Carcinoma and Conventional Pulmonary Adenocarcinoma

Cited by 49 publications

References 17 publications

Prognostic Values of Stromal Proportion and PCNA, Ki-67, and p53 Proteins in Patients with Resected Adenocarcinoma of the Lung

Prognostic Values of Stromal Proportion and PCNA, Ki-67, and p53 Proteins in Patients with Resected Adenocarcinoma of the Lung

Expression and localization of mRNAs for matrix metalloproteinases and their inhibitors in mixed bronchioloalveolar carcinomas with invasive components

Morphometric Evaluation of Nb84, Synaptophysin and Agnor Is Useful for the Histological Diagnosis and Prognosis in Peripheral Neuroblastic Tumors (Pnts)

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