Comparison of eugenol and dihydromyricetin loaded nanofibers by electro-blowing spinning for active packaging

Liu, Songqi; Chen, Zaihan; Zhang, Huange; Li, Yuanli; Taxipalati, Maierhaba; An, Jianhui; Zhou, Zhi; Deng, Lingli

doi:10.1016/j.fbio.2022.102294

Cited by 11 publications

(5 citation statements)

References 72 publications

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“…It has been reported by other authors that the addition of essential oils and plasticizers to nanofibers and zein films is able to form hydrogen bonds between the polymer chains, causing greater organization and increasing the compactness of the fibers, which ultimately decreases the T g , as well as increase the thermal stability of the material, evidenced by higher temperatures of degradation of the material. [ 7–87 ]…”

Section: Resultsmentioning

confidence: 99%

“…[ 8 ] Phenotypic differences between these cells and real tissues are well known and derive mainly from changes in gene expression due to different interactions to which cells are subjected in this microenvironment compared to their naturally 3D environment. [ 8–89 ] Since cell adhesion is a highly complex process depending on multiple biological and physicochemical factors, cell culture models that better mimic in vivo conditions provide a more precise cellular response analysis. Therefore, there is an increasing interest in developing new 3D in vitro cell culture models to pre‐screen new drugs response.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, there is an increasing interest in developing new 3D in vitro cell culture models to pre‐screen new drugs response. [ 8–91 ]…”

Section: Resultsmentioning

confidence: 99%

“…Increased MTT conversion could be led by either increased cell proliferation or interference in formazan conversion by the treatment. It is already well established that propolis in general, due to its antioxidant properties, plays an important role in mitochondrial protection against oxidative stress, [ 33–93 ] and as an antioxidant, it can interfere with the MTT assay. [ 94,95 ] Hence, the NR dye incorporation assay was performed to determine cell cytotoxicity.…”

Section: Resultsmentioning

confidence: 99%

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Preparation and Investigation of Thermally Annealed Zein–Propolis Electrospun Nanofibers for Biomedical Applications

Hochheim

Sampaio

Cruz

et al. 2023

Macromolecular Bioscience

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Zein, a corn‐derived protein, has a variety of applications ranging from drug delivery to tissue engineering and wound healing. This work aims to develop a biocompatible scaffold for dermal applications based on thermally annealed electrospun propolis‐loaded zein nanofibers. Pristine fibers' biocompatibility is determined in vitro. Next, propolis from Melipona quadrifasciata is added to the fibers at different concentrations (5% to 25%), and the scaffolds are studied. The physicochemical properties of zein/propolis precursor dispersions are evaluated and the results are correlated to the fibers' properties. Due to zein's and propolis' very favorable interactions, which are responsible for the increase in the dispersions surface tension, nanometric size ribbon‐like fibers ranging from 420 to 575 nm are obtained. The fiber's hydrophobicity is not dependent on propolis concentration and increases with the annealing procedure. Propolis inhibitory concentration (IC50) is determined as 61.78 µg mL−1. When loaded into fibers, propolis is gradually delivered to cells as Balb/3T3 fibroblasts and are able to adhere, grow, and interact with pristine and propolis‐loaded fibers, and cytotoxicity is not observed. Therefore, the zein–propolis nanofibers are considered biocompatible and safe. The results are promising and provide prospects for the development of wound‐healing nanofiber patches—one of propolis' main applications.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Therefore, there is an increasing interest in developing new 3D in vitro cell culture models to pre‐screen new drugs response. [ 8–91 ]…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Preparation and Investigation of Thermally Annealed Zein–Propolis Electrospun Nanofibers for Biomedical Applications

Hochheim

Sampaio

Cruz

et al. 2023

Macromolecular Bioscience

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“…The transformative potential of EB further ampli es the scope of these innovations. By combining electrical and air-blowing forces, EB not only addresses the challenges associated with processing viscous polymer solutions but also ampli es the e ciency and precision of nano ber production (Liu et al 2023). This simultaneous application of forces, characteristic of EB, ensures a more effective berization process, leading to the development of nano bers with unparalleled properties, a vital characteristic for the creation of next-generation food packaging materials.…”

Section: Introductionmentioning

confidence: 99%

Versatile blood carbon dots functionalized sodium alginate/polyvinyl alcohol electroblown nanofibers for rapid fabricated innovative active food packaging

ALP,

DOĞAN,

AKGUL

2024

Preprint

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This research used electroblown nanofibers made from a blend of polyvinyl alcohol (PVA) and sodium alginate (SA), activated by carbon dots obtained from bovine blood (BCDs), to create a new solution for active food packaging. The nanoscale size of BCDs revealed low toxicity on chondrocyte and lung cell types, ensuring safety in biomedical applications. The insertion of BCDs into the nanofiber matrix lowered surface hydrophobicity but strengthened water solubility and mechanical strength. These nanofibers demonstrated exceptional antioxidant activities and exhibited inhibitory effects against both E. coli and S. aureus. Conducting real food trials on chicken fillets disclosed the large reduction in viable bacteria count and lipid oxidation, consequently extending the durability of the product. Noteworthy is the eco-conscious element of these nanofibers; in soil burial experiments, the packing material disintegrated within a mere 57 days, underlining its negligible environmental impact. These environmentally friendly electroblown nanofibers, supplemented with BCDs, represent a viable future for sustainable food packaging. In seamlessly coupling food safety with eco-friendly methods, this methodology offers a comprehensive and practical answer for the packaging industry.

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Tailoring of Gelatin-Chitosan Nanofibers Functionalized with Eucalyptus Essential Oil via Electroblowing for Potential Food Packaging and Wound Dressing Applications

Elomar,

Eticha,

Doğan

et al. 2024

Fibers Polym

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In recent years, new approaches to fabricating nanofiber networks for potential applications in wound dressing and food packaging have been in the spotlight. This study aimed to produce functional webs based on gelatin, chitosan, and eucalyptus essential oil using the electro-blowing method instead of traditional spinning methods such as electrospinning. The resultant nanofiber webs exhibit promising morphological characteristics, including reduced fiber diameters, enhanced air permeability, and improved thermal stability. The integration of chitosan and eucalyptus essential oil overcomes limitations associated with gelatin, offering enhanced mechanical properties, antibacterial efficacy, and potential attributes for wound healing and food packaging. The combination of gelatin and chitosan contributes to biodegradability and biocompatibility, crucial for developing materials compatible with the natural environment. The addition of eucalyptus essential oil provides an additional layer of antimicrobial protection, aligning with sustainability goals in wound care and active food packaging. A comprehensive analysis encompassing SEM morphologies, fiber diameters, air permeability, FTIR spectra, TGA thermograms, and contact angle measurements establishes a thorough understanding of the fabricated nanofiber webs’ characteristics. Despite the favorable properties exhibited by the developed nanofiber webs for wound healing and food packaging applications, the incorporation of eucalyptus essential oil resulted in a reduction in tensile strength and elongation ratios. This observation highlights the necessity for further optimization and fine-tuning of the formulation to strike a balance between antimicrobial benefits and mechanical properties. Distinguished by its unique combination of gelatin, chitosan, and eucalyptus essential oil, this research contributes to the advancement of nanofiber technology, expanding knowledge in the field and paving the way for the development of advanced materials with enhanced therapeutic properties for wound healing and food packaging. Graphical Abstract

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Comparison of eugenol and dihydromyricetin loaded nanofibers by electro-blowing spinning for active packaging

Cited by 11 publications

References 72 publications

Preparation and Investigation of Thermally Annealed Zein–Propolis Electrospun Nanofibers for Biomedical Applications

Preparation and Investigation of Thermally Annealed Zein–Propolis Electrospun Nanofibers for Biomedical Applications

Versatile blood carbon dots functionalized sodium alginate/polyvinyl alcohol electroblown nanofibers for rapid fabricated innovative active food packaging

Tailoring of Gelatin-Chitosan Nanofibers Functionalized with Eucalyptus Essential Oil via Electroblowing for Potential Food Packaging and Wound Dressing Applications

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