Comparison of etomidate and propofol for anaesthesia in microlaryngeal surgery

Grood, P.M.R.M. de; Mitsukuri, S; Egmond, J. van; Rutten, J. M. J.; Crul, J. F.

doi:10.1111/j.1365-2044.1987.tb03976.x

Cited by 53 publications

(23 citation statements)

References 14 publications

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“…9 This drug has been shown to obtund airway reflexes and allow a relatively easy intubation in the majority of patients. 10 Similar results with the same induction technique as used in this study have been reported previously in non-myasthenic patients. 10,11 MG patients are also more sensitive than normal to neuromuscular depression by volatile anesthetic agents such as halothane and isoflurane.…”

Section: Discussionsupporting

confidence: 89%

“…10 Similar results with the same induction technique as used in this study have been reported previously in non-myasthenic patients. 10,11 MG patients are also more sensitive than normal to neuromuscular depression by volatile anesthetic agents such as halothane and isoflurane. [12][13][14] In our series, neuromuscular trasmission during surgery was more depressed with the use of sevoflurane compared with propofol, but it recovered completely at the end of anesthesia so that the mean ) extubation and mean ) awake were similar in both groups.…”

Section: Discussionsupporting

confidence: 89%

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Propofol or sevoflurane anesthesia without muscle relaxants allow the early extubation of myasthenic patients

et al. 2003

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P Pu ur rp po os se e: : To compare two non-muscle relaxant anesthetic techniques in myasthenic patients undergoing trans-sternal thymectomy, evaluating the intra-and postoperative conditions including the early extubation in the operating room.M Me et th ho od ds s: : Sixty-eight consecutive myasthenic patients undergoing trans-sternal thymectomy were prospectively randomized in two groups: propofol and sevoflurane. In both groups anesthesia was induced with propofol (1-2 mg·kg -1 ) and intubation performed after topical anesthesia of the airway with lidocaine. Anesthesia was maintained in the propofol group (36 patients) with a continuous propofol infusion (3-6 mg·kg -1 ·hr -1 ) and nitrous oxide and, in the sevoflurane group (32 patients), with sevoflurane (end-tidal 1-1.5%) in O 2 :N 2 O. Intubating conditions, hemodynamic changes, neuromuscular transmission, postoperative intensive care unit and hospital length of stay and complications were evaluated. Data were analyzed with repeated measure two-way analysis of variance (ANOVA), Chi square test and Student's t test.R Re es su ul lt ts s: : Intubating conditions were good in all patients. There were no hemodynamic changes. All patients were extubated in the operating room and none had to be re-intubated for postoperative respiratory depression. Neuromuscular transmission showed minimal changes, more important in the sevoflurane group, and at the end of the procedure the recovery was complete in all patients. We did not observe any other significant differences between the two groups studied.C Co on nc cl lu us si io on n: : Our data show that these two anesthetic techniques allow the early extubation of myasthenic patients in the operating room. Objectif

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 89%

Propofol or sevoflurane anesthesia without muscle relaxants allow the early extubation of myasthenic patients

et al. 2003

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“…[23] Various anesthetic agents and a number of alternative anesthetic techniques have been tried with varying results. [4–6] The use of intravenous anesthesia with propofol during microlaryngeal surgery is in widespread clinical practice due to its rapidity and quality of awakening. [7–9]…”

Section: Introductionmentioning

confidence: 99%

Effect of sevoflurane versus propofol-based anesthesia on the hemodynamic response and recovery characteristics in patients undergoing microlaryngeal surgery

2012

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Background:This randomized study was conducted to compare the hemodynamic changes and emergence characteristics of sevoflurane versus propofol anesthesia for microlaryngeal surgery.Methods:Forty adult patients undergoing microlaryngoscopy were randomly allocated into two groups. In propofol group, anesthesia was induced with 2-3 mg/kg propofol and maintained with propofol infusion 50-200 μg/kg/h. In sevoflurane group induction was carried out with 5-8% sevoflurane and maintained with sevoflurane in nitrous oxide and oxygen. The propofol and sevoflurane concentrations were adjusted to maintain the bispectral index of 40-60. All patients received fentanyl 2 μg/kg before induction and succinylcholine 2 mg/kg to facilitate tracheal intubation. The hemodynamic changes during induction and suspension laryngoscopy were compared. In addition, the emergence time, time to extubation, and recovery were assessed.Results:The changes in heart rate were comparable. The mean arterial pressure was significantly lower after induction and higher at insertion of operating laryngoscope in propofol group as compared to sevoflurane group. More patients in propofol group had episodes of hypotension and hypertension than sevoflurane group. The emergence time, extubation times, and recovery time were similar in both groups.Conclusion:We found that sevoflurane showed advantage over propofol in respect of intraoperative cardiovascular stability without increasing recovery time.

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“…In surgery requiring intravenous anesthesia without intubation in laryngomicrosurgery, TIVA for anesthesia has been reported to use propofol alone [11], narcotic analgesia and propofol [12], and a combination of propofol and fentanyl [13].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of total intravenous anesthesia without intubation for laryngeal framework surgery

Nakamura

Muto

Yoshida

et al. 2008

Acta Oto-Laryngologica

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Comparison of etomidate and propofol for anaesthesia in microlaryngeal surgery

Cited by 53 publications

References 14 publications

Propofol or sevoflurane anesthesia without muscle relaxants allow the early extubation of myasthenic patients

Propofol or sevoflurane anesthesia without muscle relaxants allow the early extubation of myasthenic patients

Effect of sevoflurane versus propofol-based anesthesia on the hemodynamic response and recovery characteristics in patients undergoing microlaryngeal surgery

Efficacy of total intravenous anesthesia without intubation for laryngeal framework surgery

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