Abstract:-Background -Chagas' disease and the aging process cause loss of neurons of the esophageal myenteric plexus.Aim -To evaluate the esophageal motility impairment caused by Chagas' disease in two age groups. Our hypothesis was that the aging process may cause further esophageal motility impairment in patients with Chagas' disease. Methods -We studied the esophageal motility of 30 patients with Chagas' disease and dysphagia, with esophageal retention of barium sulfate and an esophageal diameter within the normal r… Show more
“…[1][2][3][4] Although its incidence is declining, an impressive number of individuals still suffer from this disease, 1 and it has a wide distribution in Central and South America. It has been reported in all countries in the Americas, except in Canada.…”
The diagnosis of lipoid pneumonia should be considered in chagasic patients with megaesophagus and a history of aspirating mineral oil, presenting with parenchymal consolidations or crazy-paving pattern in HRCT.
“…[1][2][3][4] Although its incidence is declining, an impressive number of individuals still suffer from this disease, 1 and it has a wide distribution in Central and South America. It has been reported in all countries in the Americas, except in Canada.…”
The diagnosis of lipoid pneumonia should be considered in chagasic patients with megaesophagus and a history of aspirating mineral oil, presenting with parenchymal consolidations or crazy-paving pattern in HRCT.
“…This finding is associated with senescence that causes dysmotility ( Meciano-Filho et al 1995 ). In ChD patients,
radiographic findings indicate that oesophageal motility is more impaired in patients
with advanced age compared with younger patients and this is also related to senescence
( Dantas & Aprile 2006 ). The reduction of
the PGP9.5-IR area observed in the Be-78 group during the chronic phase was
significantly greater than that caused by senescence in NI animals, however and for this
reason it was considered to be denervation due to ChD.…”
Chagasic megaoesophagus and megacolon are characterised by motor abnormalities
related to enteric nervous system lesions and their development seems to be related
to geographic distribution of distinct Trypanosoma cruzi
subpopulations. Beagle dogs were infected with Y or Berenice-78 (Be-78) T.
cruzi strains and necropsied during the acute or chronic phase of
experimental disease for post mortem histopathological evaluation of
the oesophagus and colon. Both strains infected the oesophagus and colon and caused
an inflammatory response during the acute phase. In the chronic phase, inflammatory
process was observed exclusively in the Be-78 infected animals, possibly due to a
parasitism persistent only in this group. Myenteric denervation occurred during the
acute phase of infection for both strains, but persisted chronically only in Be-78
infected animals. Glial cell involvement occurred earlier in animals infected with
the Y strain, while animals infected with the Be-78 strain showed reduced glial
fibrillary acidic protein immunoreactive area of enteric glial cells in the chronic
phase. These results suggest that although both strains cause lesions in the
digestive tract, the Y strain is associated with early control of the lesion, while
the Be-78 strain results in progressive gut lesions in this model.
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