Comparison of epinephrine and felypressin pressure effects in 1K1C hypertensive rats treated or not with atenolol

Abstract

Our results suggest that felypressin has equipotent pressure responses when compared with epinephrine, showing a greater extent of action. Atenolol's reduction of hypertensive effects surprisingly suggests that atenolol β-blockade may also be important for felypressin's cardiovascular effect, as is widely known for epinephrine. Our data suggest that felypressin is safe for hypertensive subjects, in particular those receiving atenolol.

2% lidocaine versus 3% prilocaine for oral and maxillofacial surgery

“…However, prilocaine has pKa of 7.7 and protein binding of 55%, potency of 2, and relative toxicity of 1. [ 14 22 ]…”

“…Sub-periosteum injection technique is very painful because the needle will perforate the periosteum membrane in and this action is considered very painfu. [ 10 14 ] The nasopalatine and greater palatine nerves provide the sensory innervation of the palatine bone, periosteum, and mucosa. [ 22 ] Second account is the nature of palatal mucosa or gingiva, which is very adhesive to underneath bone.…”

“…2% Lidocaine with 1:80,000/1:100,000 adrenaline remains the gold standard dental LA with teaching about its safety and uses in all but some situations. [ 12 13 14 ] Based on the literature, adrenaline is considered a stronger vasoconstrictor than felypressin, and as a consequence, longer duration of action will be achieved. However, felypressin is a synthetic hormone with similar properties to vasopressin.…”

Impacto do Tabagismo Passivo na Resposta Pressórica à Epinefrina e Felipressina em Ratos Hipertensos 1K1C Tratados ou não com Atenolol

“…Male Wistar rats weighing 140 to 320 g provided by Faculdade de Odontologia de Bauru facilities were used in all groups of this study. The experimental hypertension method, indirect and direct BP measurements, were performed as previously described 10 . All rats received a normal diet, free water and food access and were submitted to 12 hour light/dark cycle.…”

“…A previous study showed reduced hypertensive effect of felypressin in rats treated with atenolol. 10 In order to increase the knowledge about the safety of epinephrine and felypressin, this study attempted to test them isolated in intravascular administration to simulate the maximal error in local anesthesia, providing information for the formulation of safer local anesthetic solutions. Therefore, the aim of this study was to evaluate and compare the effects of direct intravenous injection of epinephrine and felypressin on blood pressure of smoker or non-smoker normotensive, hypertensive and atenolol-treated hypertensive rats.…”