Comparison of enhancement of the vestibular perilymph between gadoterate meglumine and gadobutrol at 3-Tesla in Meniere's disease

Abstract

Gadobutrol and gadoterate meglumine provide similar degrees of enhancement of the symptomatic ear in patients with Meniere's disease but gadobutrol provides better anatomical details regarding endolymphatic space and semicircular canals of asymptomatic, contralateral ear.

Relationship between video head impulse test, ocular and cervical vestibular evoked myogenic potentials, and compartmental magnetic resonance imaging classification in menière's disease

“…MRI examinations were carried out on a 3T scanner (3T Siemens Skyra; Siemens Healthineers, Erlangen, Germany) with a 64‐channel head–neck–spine coil. All patients underwent an MRI scan 4 hours after a single intravenous dose of gadobutrol (Gd‐DO3A‐butrol, Gadovist 0.1 mmol/kg, 1 mmol/mL) that provided a high contrast in the labyrinth . We performed the three‐dimensional fluid‐attenuated inversion recovery (3D‐FLAIR) MRI with the following parameters: field of view: 160 × 160 mm, repetition time: 10,000 milliseconds, echo time: 323 milliseconds, inversion time: 2,500 milliseconds, 320 × 280, flip angle: 180°, number of excitations: 2, GeneRalized Autocalibrating Partial Parallel Acquisition: 2, and scan time of 7 minutes 50 seconds.…”

Vestibular atelectasis: Myth or reality?

“…MRI examinations were carried out on a 3 T scanner (3 T Siemens Skyra; Siemens Healthineers, Erlangen, Germany) with a 64‐channel head‐neck‐spine coil. All patients underwent an MRI scan 4 hours after a single intravenous dose of gadobutrol (Gd‐DO3A‐butrol Gadovist 0.1 mmol/kg, 1 mmol/mL) that provided a high contrast in the labyrinth . We performed the 3D‐FLAIR with the following parameters: field of view: 160 × 160 mm, repetition time: 10,000 ms, echo time: 323 ms, inversion time: 2500 ms, 320 × 280, flip angle: 180°, number of excitations: 2, generalized autocalibrating partially parallel acquisitions: 2, and scan time of 7 minutes 50 seconds.…”

State of the Art Imaging in Menière’s Disease. Tips and Tricks for Protocol and Interpretation

“…The latter located partly within the VA and partly within the dura of the posterior fossa. The contrast effect in symptomatic ears of MD patients was reported to be comparable between eightfold diluted gadopentate gimeglumine and gadodiamide for the IT method, and between gadoterate megluminate and gadobutrol for the IV method respectively [40,41]. However, the perilymph signal intensity in the contralateral asymptomatic ear was reported to be higher with IV gadobutrol than IV gadoterate megluminate, which benefits assessment of silent (subclinical) EH [41].…”

“…The contrast effect in symptomatic ears of MD patients was reported to be comparable between eightfold diluted gadopentate gimeglumine and gadodiamide for the IT method, and between gadoterate megluminate and gadobutrol for the IV method respectively [40,41]. However, the perilymph signal intensity in the contralateral asymptomatic ear was reported to be higher with IV gadobutrol than IV gadoterate megluminate, which benefits assessment of silent (subclinical) EH [41]. The difference in the degree of T1 shortening of the gadolinium(Gd)-enhanced perilymph between these two contrast agents has not been fully clarified, but is likely due to the greater longitudinal relaxivity of gadobutrol [41,42].…”

“…However, the perilymph signal intensity in the contralateral asymptomatic ear was reported to be higher with IV gadobutrol than IV gadoterate megluminate, which benefits assessment of silent (subclinical) EH [41]. The difference in the degree of T1 shortening of the gadolinium(Gd)-enhanced perilymph between these two contrast agents has not been fully clarified, but is likely due to the greater longitudinal relaxivity of gadobutrol [41,42]. This finding may be relevant with regard to future development of low-dose Gd-enhanced MRI protocols for hydrops imaging.…”