Comparison of Endoscopic Ultrasonography and Multidetector Computed Tomography for Detecting and Staging Pancreatic Cancer

Abstract

Compared with multidetector CT, endoscopic ultrasonography is superior for tumor detection and staging but similar for nodal staging and resectability of preoperatively suspected nonmetastatic pancreatic cancer.

Prognostic value of lymph node metastases detected during surgical exploration for pancreatic or periampullary cancer: A systematic review and meta-analysis

“…12,26 The accurate determination of (loco) regional LNM by endoscopic ultrasonography (EUS) even seems similar. [42][43][44] Extra-regional lymph nodes may not be visible on EUS. This suggests that in case of clinical consequences such as aborting a surgical exploration, standard intraoperative sampling of hepatic-artery and para-aortic lymph nodes should be performed.…”

Serum CA 19-9 as a Biomarker for Pancreatic Cancer—A Comprehensive Review

“…Moreover, CA 19-9 serum levels alone should not be the sole criteria used in making decisions to proceed to surgery; rather CA 19-9 serum levels is one of several contributing factors used in combination with clinical evaluation and information obtained from radiological and endoscoping imaging. Advances in radiologic [CT scan, Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET scan) and endoscopic imaging (Endoscopic Ultrasound (EUS), ERCP)] as well as the use of laparoscopy have enabled better delineation and staging of pancreatic cancer and helped to reduce the negative laparotomy rate [27,28]. Nevertheless, up to 15% of patients with pancreatic cancer are found unresectable at the time of surgery, which is attributable to occult vascular invasion, presence of undetected metastasis or positive peritoneal lavage cytology [25].…”

Light scattering spectroscopy identifies the malignant potential of pancreatic cysts during endoscopy

“…Despite the recent improvements in CT and MRI methodologies, these imaging approaches are unable to distinguish cancerous, premalignant and benign cysts reliably, in part due to a lack of sensitivity to cellular structure and biochemical properties, with wide variations in the reported accuracy ranging from 20% to 80% 37 . EUS is still the most sensitive technique currently available for the detection of small (<2–3 cm) pancreatic cysts 38,39 , however, the accuracy of EUS for distinguishing mucinous from non-mucinous cysts is only 51% 6 . Because imaging techniques have a limited ability of identifying the type of pancreatic cyst, there has been a major effort to identify the cyst type with cyst fluid obtained during EUS-FNA procedures.…”