Comparison of endoscopic techniques designed for posterior glottic stenosis—A cadaver morphometric study

Sztanó, Balázs; Szakács, László; Madani, Shahram; Tóth, Ferenc; Bere, Zsófia; Castellanos, Paul F.; Rovó, László

doi:10.1002/lary.24270

Cited by 12 publications

(9 citation statements)

References 27 publications

(47 reference statements)

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“…A task‐orientated modification of the prior study design was used . One hundred freshly excised cadaver larynges (50 male, 50 female) were analyzed.…”

Section: Methodsmentioning

confidence: 99%

“…A task-orientated modification of the prior study design was used. 15 One hundred freshly excised cadaver larynges (50 male, 50 female) were analyzed. Larynges were inserted into a fixation device and secured with three screws along the cricoid cartilage, avoiding deformation caused by the screws.…”

Section: Cadaver Workupmentioning

confidence: 99%

“…A cadaver study has been designed to provide an objective answer to these questions by applying these methods to the anticipated breathing and phonatory characteristics of the basic endoscopic glottis‐enlarging procedures designed for BVCI.…”

Section: Introductionmentioning

confidence: 99%

“…9 Additionally, studies in the last decades have revealed that vocal cord paralysis is not a static condition. Possible residual motion 10,11 due to additional or residual innervation, 12 From the Department of Otorhinolaryngology-Head and Neck Surgery (L.S., B A cadaver study has been designed to provide an objective answer to these questions 14,15 by applying these methods to the anticipated breathing and phonatory characteristics of the basic endoscopic glottisenlarging procedures designed for BVCI.…”

Section: Introductionmentioning

confidence: 99%

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A comparison between transoral glottis‐widening techniques for bilateral vocal fold immobility

et al. 2015

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“…A task‐orientated modification of the prior study design was used . One hundred freshly excised cadaver larynges (50 male, 50 female) were analyzed.…”

Section: Methodsmentioning

confidence: 99%

Section: Cadaver Workupmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A comparison between transoral glottis‐widening techniques for bilateral vocal fold immobility

et al. 2015

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“…The Endoscopic Arytenoid Abduction Lateropexy (EAAL) is a really effective totally reversible, non-resection 'simple suture' glottis enlarging procedure. Our recent publications objectively proved its efficacy [4][5][6][7]. Now, this concept is introduced in a really young patient.…”

Section: Introductionmentioning

confidence: 94%

Endoscopic Arytenoid Abduction Lateropexy for the Treatment of Bilateral Vocal Cord Paralysis in Early Childhood: Case Report

Sztanó¹,

Bach²,

Matievics³

et al. 2018

Am J Otolaryngol Head Neck Surg

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Objectives: The treatment of bilateral vocal cord paralysis in early childhood is really challenging even now a days. One of the treatment options is endoscopic arytenoid abduction lateropexy; a reversible simple suture vocal cord lateralizing technique, the arytenoid cartilage is directly lateralized to normal abducted position. Authors introduce a case of a successfully treated toddler. Methods: The 2.5 years old boy had noisy breathing and dyspnea on exertion since delivery. Laryngo-tracheoscopy revealed bilateral vocal cord paralysis. Unilateral, left-sided endoscopic arytenoid abduction lateropexy was performed with supraglottic jet ventilation. Results: He remained intubated for 3 with an uncuffed tracheal tube. After extubation, no dyspnea or swallowing disorder occurred. During the follow-up laryngo-tracheoscopies, clinical growth charts and voice analysis showed satisfactory functional results. Conclusions: The endoscopic arytenoid abduction lateropexy is a minimally invasive, quick, reversible endoscopic glottis enlarging procedure, which might be a favorable solution for neonatal bilateral vocal cord paralysis even in early childhood. It provides immediately wide airway without any permanent damage to voice production.

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Antifibrotic effect of mitomycin‐C on human vocal cord fibroblasts

et al. 2019

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Objective: Acquired laryngotracheal stenosis is a potentially life-threatening situation and a very difficult and challenging problem in laryngology. Therefore, new trends and innovative approaches based on antifibrotic drugs and minimally invasive regimens are being developed to attenuate laryngotracheal fibrosis and scarring. The purpose of this study was to examine the efficacy of mitomycin-C (MMC) to reverse the transforming growth factor (TGF)-β-induced differentiation of MRC-5 fibroblast and human primary vocal cord fibroblasts to reveal the possible applicability of MMC to laryngotracheal fibrotic conditions.Methods: Human primary fibroblast cells were isolated from vocal cord specimens of patients undergoing total laryngectomy. The established primary vocal cord fibroblast cell cultures as well as the MRC-5 human fibroblast cells were treated with 5 ng/mL TGF-β alone and then with 0.5 μg/mL MMC for 24 hours. Differentiation of fibroblasts was characterized by α-smooth muscle actin (α-SMA) immunhistochemistry, Western blot analysis, and real-time polymerase chain reaction. Cell motility was assessed by wound-healing assay.Results: Elevated α-SMA mRNA and protein expression as well as increased cell motility were observed upon TGF-β exposures. However, after MMC treatments the TGF-β-induced fibroblasts exhibited a significant decrease in α-SMA expression and wound-healing activity. Therefore, TGF-β-stimulated fibroblast-myofibroblast transformation was reversed at least in part by MMC treatment. Histopathological examinations of tissue specimens of a laryngotracheal stenosis patient supported these findings.Conclusion: Antifibrotic effects of MMC were demonstrated on the human MRC-5 cell line and on primary vocal cord fibroblast cultures. These results verify that MMC can be used with success to reverse upper airway stenosis by reverting the myofibroblast phenotype.

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Comparison of endoscopic techniques designed for posterior glottic stenosis—A cadaver morphometric study

Abstract: Our morphometric study proved that organ-preserving EAAL provided more space in the posterior glottic area. Fibrous reconnection and contraction of the scar can be minimized in this way, which may be the clinical efficacy explanation.

Cited by 12 publications

References 27 publications

A comparison between transoral glottis‐widening techniques for bilateral vocal fold immobility

A comparison between transoral glottis‐widening techniques for bilateral vocal fold immobility

Endoscopic Arytenoid Abduction Lateropexy for the Treatment of Bilateral Vocal Cord Paralysis in Early Childhood: Case Report

Antifibrotic effect of mitomycin‐C on human vocal cord fibroblasts

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