“…None of the studies found significant differences in disease management parameters. [77][78][79]92,93,99,102,103 In most of the studies, patients underwent both level 1 and level 3 tests to avoid the risk of internal bias due to differences between study groups. In all of the simultaneous studies, level 3 tests were scored manually by the same technician who scored the level 1 test, which may have resulted in observer bias.…”