Comparison of efficacy of three commercially available dentifrices on dentinal hypersensitivity: a randomized clinical trial

Pradeep, A.R.; Agarwal, Esha; Naik, SB; Bajaj, Pavan; Kalra, Namita

doi:10.1111/j.1834-7819.2012.01726.x

Cited by 36 publications

(74 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pradeep et al [64] was a triple-blinded, randomized controlled trial. Randomization was generated via a random computer table and the investigators were not involved in this procedure to ensure their blinding.…”

Section: Resultsmentioning

confidence: 99%

The Efficacy of Selected Desensitizing OTC Products: A Systematic Review

2014

View full text Add to dashboard Cite

Objectives. The aim of the present study was to review the published literature in order to identify relevant studies for inclusion and to determine whether there was any evidence on the clinical effectiveness of selected desensitizing toothpastes, calcium sodium phosphosilicate (CSPS), amorphous calcium phosphate (ACP), nanohydroxyapatite, and casein phosphopeptide-amorphous calcium phosphate (tooth mousse) on reducing dentine hypersensitivity (DH). Materials and Methods. Following a review of 593 papers identified from searching both electronic databases (PUBMED) and hand searching of relevant written journals, only 5 papers were accepted for inclusion. Results. Analysis of the included studies (3 CSPS and 2 ACP) would suggest that there may be some benefit for patients using these products for reducing DH. No direct comparative studies were available to assess all these products under the same conditions neither were there any comparative randomised controlled studies that compared at least two of these products in determining their effectiveness in treating DH. Conclusions. Due to the small number of included studies, there are limited clinical data to support any claims of clinical efficacy of these OTC products. Further studies are therefore required to determine the efficacy of these products in well-controlled RCT studies with a larger sample size.

show abstract

Section: Resultsmentioning

confidence: 99%

The Efficacy of Selected Desensitizing OTC Products: A Systematic Review

2014

View full text Add to dashboard Cite

show abstract

“…Para ello se contactó una motita de algodón embebida en tetrafluoretano (TFE) en spray de aproximadamente 2 mm de diámetro, que fue aplicada en el tercio cervical de la corona dentaria por 1 segundo, procurando no tocar la encía. Ambas pruebas fueron realizadas con aislación relativa, asegurándose de cubrir toda la superficie de los dientes vecinos (14) . La cuantificación del dolor se realizó a través de EVA, de modo que 10 mm se consideró como un punto EVA.…”

Section: Materials Y Métodounclassified

Eficacia de la Arginina al 8% y Nitrato Potásico al 5% en el tratamiento de la hipersensibilidad dentinaria. Ensayo clínico aleatorio.

Tobar

Soto

Venezia

et al. 2017

Rev. Clin. Periodoncia Implantol. Rehabil. Oral

View full text Add to dashboard Cite

Eficacia de la Arginina al 8% y Nitrato Potásico al 5% en el tratamiento de la hipersensibilidad dentinaria. Ensayo clínico aleatorio.Efficacy of 8% Arginine and 5% Potassium Nitrate in Dentin Hypersensitivity Therapy. A randomized clinical trial.Alexis Tobar 1+ , Iván Soto 1+ , Claudia Da Venezia 1 , Johanna Contreras 2 , Alicia Morales 2 , Paola Carvajal 2 , Patricia Hernández-Ríos 2* . RESUMENObjetivo: Comparar la eficacia clínica de dentífricos en base a arginina al 8%/ monofluorfosfato de sodio 1450 ppm versus nitrato de potasio al 5%/fluoruro de sodio 2500 ppm en la terapia de la hipersensibilidad dentinaria (HSD). Materiales y método: Ensayo clínico, aleatorio, controlado, doble ciego, de grupos paralelos. Treinta y cuatro voluntarios de 18 a 70 años, con HSD en escala Visual Análoga (EVA) ≥4 en 2 ó más dientes no molares, fueron distribuidos aleatoriamente en 2 grupos: grupo T1 (n=16): dentífrico de Arginina al 8%/ monofluorfosfato de sodio 1450 ppm; y grupo T2 (n=18): dentífrico de nitrato de Potasio al 5%/fluoruro de sodio 2500 ppm. Se evaluó HSD en EVA con estímulos evaporativos y térmicos, y se compararon sus valores, así como el grado promedio de HSD y su reducción (∆HSD), intra e intergrupal, al inicio y a las 4 semanas de tratamiento. Resultados: Ambos dentífricos disminuyeron el grado promedio de HSD entre el inicio y las 4 semanas de tratamiento (T1: 5.03 ± 1.23 versus 2.60 ± 1.27, p<0.05; T2: 4.73 ± 1.51 versus 2.71 ± 1.17, p<0.05). No hubo diferencias estadísticamente significativas entre ambos dentífricos al comparar el grado promedio de reducción de HSD durante la terapia (∆HSD T1: -2.43 ± 1.22 versus ∆HSD T2: -2.27 ± 1.42). Los datos fueron analizados en Stata versión 11. Conclusiones: Ambos dentífricos fueron clínicamente eficaces en reducir la HSD a las 4 semanas, sin existir diferencias estadísticamente significativas entre ambos. PALABRAS CLAVESensibilidad dentinaria; arginina; nitrato de potasio; dentífrico; ensayo clínico aleatorio.Rev. Clin. Periodoncia Implantol. Rehabil. Oral Vol. 10(2); 121-124, 2017. ABSTRACT Aim:To compare the clinical efficacy of 8% arginine/1450ppm sodium monofluorophosphate and 5% potassium nitrate/2500 ppm sodium fluoride dentifrices in the treatment of dentin hypersensitivity (DH). Methods: Paralleldesign, double-masked, randomized controlled clinical trial. Thirty four volunteers aged 18 to 70 years, with DH and a visual analog scale (VAS) score ≥4 at least in two or more non-molar teeth, were randomized in two groups: T1 (n=16): 8% arginine/1450 ppm sodium monofluorophosphate dentifrice; and T2 (n=18): 5% potassium nitrate/2500 ppm sodium fluoride dentifrice. DH was assessed with evaporative and thermal stimuli; and their VAS measurements, mean DH value and DH reduction (∆DH) were compared, inside and between the groups at baseline and 4-week follow-up. Data were analysed through Stata® V11 program. Results: Both toothpastes decreased mean DH value between baseline and 4 weeks (T1: 5.03 ± 1.23 versus 2.60 ± 1.27, p<0.05; T2: 4.73 ± 1.51 versus 2.71 ± 1.17...

show abstract

“…Tubule-occluding agents, such as strontium and stannous salts, bioglasses, silicas or oxalates [8][9][10][11][12][13], seal or block the dentinal tubules by precipitating insoluble materials onto the dentine surface and/or within the dentinal tubules, thereby reducing the effect of external stimuli on dentinal fluid movement [14]. Some evidence suggests that occlusion-based agents may provide faster relief of DH than those based on nerve depolarisation [15].…”

Section: Introductionmentioning

confidence: 99%

Assessment of tubule occlusion properties of an experimental stannous fluoride toothpaste: A randomised clinical in situ study

West

Seong

Hellin

et al. 2018

Journal of Dentistry

View full text Add to dashboard Cite

Keywords:Crossover Dentine hypersensitivity Dentinal tubule occlusion in situ model Stannous fluoride Toothpaste A B S T R A C TObjectives: To evaluate the ability of a modified in situ model to differentiate dentinal tubule occlusion properties of toothpaste formulations over 10 days of treatment.Methods: This was a single-centre, three-treatment period, crossover, randomised, single-blind study with healthy participants wearing two lower oral appliances, each retaining four dentine samples, for 10 treatment days during each period of the study. Samples were power-brushed ex vivo twice on each treatment day with a Test toothpaste containing 0.454% stannous fluoride, a Control fluoride toothpaste containing 0.76% sodium monofluorophosphate, or mineral water. Dentine samples were subjected to in situ acid challenge (orange juice) on Days 9 and 10. Scanning electron microscopy images obtained at baseline and after 1, 4, 8 and 10 days of treatment were graded for degree of surface coverage by four calibrated examiners; the primary study endpoint was Day 8. Results: After 4, but not 8, days' treatment, the degree of tubule occlusion increased in the dentine samples treated with the Test or Control toothpastes compared with the water-treated samples (p < 0.01 and p < 0.05, respectively). Following the acid challenge (Day 10), there was a statistically significantly greater degree of occlusion in the Test toothpaste-treated dentine samples compared with those treated with water (p < 0.01). No other comparisons were statistically significant. All study treatments were generally well-tolerated. Conclusions: This modified in situ model was unable to demonstrate statistically significant between-treatment differences in dentinal tubule occlusion after 8 days. Conversely, there are recognised developments that could be made to better identify product differences. Clinicaltrials.gov: NCT02768194. Clinical significance: Dentine hypersensitivity can be managed through brushing with stannous fluoride toothpastes, which occlude patent dentine tubules. Clinical studies measure pain but in situ models are needed to demonstrate occlusion intra-orally. However, this study did not demonstrate superior occlusion with stannous toothpaste; further methodological development is required to investigate its mode of action.

show abstract

Comparison of efficacy of three commercially available dentifrices on dentinal hypersensitivity: a randomized clinical trial

Cited by 36 publications

References 31 publications

The Efficacy of Selected Desensitizing OTC Products: A Systematic Review

The Efficacy of Selected Desensitizing OTC Products: A Systematic Review

Eficacia de la Arginina al 8% y Nitrato Potásico al 5% en el tratamiento de la hipersensibilidad dentinaria. Ensayo clínico aleatorio.

Assessment of tubule occlusion properties of an experimental stannous fluoride toothpaste: A randomised clinical in situ study

Contact Info

Product

Resources

About