Comparison of efficacy of silicone gel, silicone gel sheeting, and topical onion extract including heparin and allantoin for the treatment of postburn hypertrophic scars

Karagöz, Hüseyi̇n; Yüksel, Fuat; Ülkür, Ersi̇n; Evinc, Rahmi

doi:10.1016/j.burns.2009.06.206

Cited by 86 publications

(104 citation statements)

References 14 publications

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“…Allantoin is known to have supportive effects on the primary and secondary wound healing process (Hosnuter et al 2007;Koc et al 2008;Karagoz et al 2009;Muangman et al 2011). It was shown that heparin, cepae extract and allantoin mixtures decrease dermal scar formation more effectively than steroids (Beuth et al 2006;Temiz et al 2009).…”

Section: Discussionmentioning

confidence: 99%

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Effects of extractum cepae, heparin, allantoin gel and silver sulfadiazine on burn wound healing: an experimental study in a rat model

Durmuş¹,

Yaman²,

Can³

2012

Vet. Med. - Czech

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ABSTRACT:These experiments were conducted in order to compare the effects of extractum cepae, heparin, allantoin gel (CTBX) and silver sulfadiazine (SSD) cream on burn wound healing in rats. Thirty six adult, female Wistar albino rats were divided into three equal groups. A burn was made on the back of all rats. The burned areas in the first, second and third groups were covered with cold cream (control), SSD skin cream and CTBX twice a day, respectively. Seven and 14 days later, the rats were sacrificed and burned skin tissue samples were collected from the rats for histopathological examinations. Histopatological evaluations on the 7 th and 14 th daysshowed burn healing to be better in the CTBX and SSD groups with respect to the control group. The best burn wound healing was observed in the CTBX group (P < 0.001). Wound healing was significantly different between the groups at days 7 and 14 (P < 0.001). In conclusion, application of CTBX has significant positive effects on the healing of burn wounds in a rat model.

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Section: Discussionmentioning

confidence: 99%

“…In clinical practice, this drug is generally used for hypertrophic scars and keloids (Hosnuter et al 2007;Koc et al 2008;Karagoz et al 2009). …”

mentioning

confidence: 99%

Effects of extractum cepae, heparin, allantoin gel and silver sulfadiazine on burn wound healing: an experimental study in a rat model

Durmuş¹,

Yaman²,

Can³

2012

Vet. Med. - Czech

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“…Enoxaparin sodium (LMWH) was chosen as a model drug requiring long-term application which determines therapeutic effectiveness. Previous in vivo and in vitro research showed the efficacy of heparin commonly used in topical preparations such as gels and ointments for treatment of hypertrophic scars and keloids due to influencing human skin fibroblast cells (Karagoz et al, 2009;Pikuła et al, 2014). Silicone films containing enoxaparin (LMWH) were developed as an alternative for inconvenient daily application of silicone dressing without active substances.…”

Section: Introductionmentioning

confidence: 99%

Double layer adhesive silicone dressing as a potential dermal drug delivery film in scar treatment

Mojsiewicz‐Pieńkowska

Jamrógiewicz

Żebrowska

et al. 2015

International Journal of Pharmaceutics

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“…In some studies, it was found to improve scar symptoms and appearance, but it was not more efficacious than a petroleum-based emollient control, and was less efficacious than silicone gel or silicone sheeting. 5,6 However, when used in combination with other therapies its therapeutic effect is enhanced versus either silicone gel sheeting or intralesional corticosteroid injections alone. 5,7,8 In a prospective study, significant improvement in cosmesis, induration, pigmentation, and tenderness of scars were found using onion extract versus controls.…”

Section: Discussion Of Findings and Relevant Literature Topical Scar mentioning

confidence: 99%

Emerging Therapies for Scar Prevention

Block

Gosain

2015

Advances in Wound Care

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Significance: There are *12 million traumatic lacerations treated in the United States emergency rooms each year, 250 million surgical incisions created worldwide every year, and 11 million burns severe enough to warrant medical treatment worldwide. In the United States, over $20 billion dollars per year are spent on the treatment and management of scars. Recent Advances: Investigations into the management of scar therapies over the last decade have advanced our understanding related to the care of cutaneous scars. Scar treatment methods are presented including topical, intralesional, and mechanical therapies in addition to cryotherapy, radiotherapy, and laser therapy. Critical Issues: Current treatment options for scars have significant limitations. This review presents the current and emerging therapies available for scar management and the scientific evidence for scar management is discussed. Future Directions: Based upon our new understanding of scar formation, innovative scar therapies are being developed. Additional research on the basic science of scar formation will lead to additional advances and novel therapies for the treatment of cutaneous scars.

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Comparison of efficacy of silicone gel, silicone gel sheeting, and topical onion extract including heparin and allantoin for the treatment of postburn hypertrophic scars

Cited by 86 publications

References 14 publications

Effects of extractum cepae, heparin, allantoin gel and silver sulfadiazine on burn wound healing: an experimental study in a rat model

Effects of extractum cepae, heparin, allantoin gel and silver sulfadiazine on burn wound healing: an experimental study in a rat model

Double layer adhesive silicone dressing as a potential dermal drug delivery film in scar treatment

Emerging Therapies for Scar Prevention

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