Comparison of efficacy of buccal versus vaginal misoprostol in first trimester induced abortion

Abstract

Background: To compare the effectiveness, side effects, and patient satisfaction of buccal versus vaginal misoprostol administration in first trimester abortions.Methods: Women opting for first trimester abortion received oral Mifepristone followed 48 hours latermisoprostol. Group A received Misoprostol via buccal route whereas group B received Misoprostol vaginally. A comparative analysis using SPSS was done.Results: Giving 800µg Misoprostol by either buccal or vaginal route after oral Mifepristone have comparable efficacy in terms of complete abortion rate (96% in buccal group versus 98% in vaginal group; p value = 0.495), failure rate being statistically similar (4% versus 2%). Drug abortion interval was comparable in the two groups. (11.16 hour in buccal group and 12.32 hours in vaginal group). Few side effects like nausea and vomiting, shivering, diarrohea was significantly higher with vaginal Misoprostol while abdominal cramps, altered taste were found more with the buccal group.Conclusions: Buccal Misoprostol is comfortable and easier to administer when compared to other routes and it has potential to be developed as a self-administered regimen. Buccal Misoprostol is as efficacious as vaginal Misoprostol with significantly lesser side effects up to 7 weeks of period of gestation.

A comparison of buccal versus vaginal misoprostol administration for induction of first and second trimester abortion

“…There was no significant difference between the two study groups with respect to induction to abortion time. Overall mean induction to abortion time in buccal group was 13.15±4.01 hours as compared to 13.16±4.14 hours in vaginal group which was comparable to that reported by Khan et al 13 While et al reported induction to abortion time to be significantly longer in buccal group (40±29 hours) as compared to present study. 14 However, we found complete abortion rate to be significantly higher in buccal (88%) as compared to vaginal group (75%) while in Khan et al 13 They reported higher complete abortion rate in both buccal (96%) as well as in vaginal (98%) group.…”

“…Overall mean induction to abortion time in buccal group was 13.15±4.01 hours as compared to 13.16±4.14 hours in vaginal group which was comparable to that reported by Khan et al 13 While et al reported induction to abortion time to be significantly longer in buccal group (40±29 hours) as compared to present study. 14 However, we found complete abortion rate to be significantly higher in buccal (88%) as compared to vaginal group (75%) while in Khan et al 13 They reported higher complete abortion rate in both buccal (96%) as well as in vaginal (98%) group. Young et al found that buccal administration of misoprostol resulted in higher success rate before 64 days of gestation whereas vaginal misoprostol had a higher success rate through 70 days of gestation.…”