Comparison of Efficacy of Adjuvant MEC (Methotrexate, Epirubicin and Cisplatin) and GC (Gemcitabine and Cisplatin) in Advanced Upper Tract Urothelial Carcinoma

Effects of Chemotherapy-Induced Neutropenia on Overall Survival in Patients With Unresectable or Metastatic Urothelial Carcinoma to Gemcitabine Plus Cisplatin Combination Chemotherapy

“…In addition, several studies have suggested that age, BMI, baseline ALP levels, or the presence of visceral metastases influence the OS of UC patients treated with chemotherapy. 3,[11][12][13][14] However, in the present study, these factors were not found to be predictive for OS in patients with unresectable or metastatic UC.…”

“…Prognostic factors were examined by multivariate analyses and adjusted for clinically relevant factors that have been identified in previous studies. 3,[9][10][11][12][13][14] These factors were analyzed using the Cox proportional hazards model and the hazard ratio (HR) and 95% CI were estimated. A probability (P) value of <0.05 was considered statistically significant.…”

“…First, because this was a retrospective study, performance status was not evaluated despite it being a potent prognostic factor for the response of various cancers to chemotherapy. 3,[10][11][12]14,25 Second, blood samplings were not unified in each patient because these data were obtained from routine clinical practice. Ideally, assessment time points of neutrophil counts should be unified; however, in this study, we were limited to patients who were sampled for blood every 7 days.…”

“…[4][5][6][7][8] Several clinical variables, including age, body mass index (BMI), baseline hemoglobin (Hb), alkaline phosphatase (ALP), as well as the presence of visceral metastases, have been reported to be prognostic factors of UC in response to chemotherapy. 3,[9][10][11][12][13][14] However, the prognostic relevance of early-onset severe CIN on patient survival in cases of unresectable or metastatic UC remains unknown. Therefore, the aim of the present study was to investigate the association between early-onset CIN and OS in UC patients receiving GC chemotherapy.…”

Effects of Long Noncoding RNA H19 Polymorphisms on Urothelial Cell Carcinoma Development

“…Patients with UCC were clinically diagnosed and staged according to the tumor–node–metastasis staging system of the American Joint Committee on Cancer [26]. The treatment protocol of these patients included radical nephroureterectomy and bladder cuff excision with lymph node dissection, as described previously [27]. For the control group, 431 sex-matched healthy controls (272 men and 159 women with a mean age of 59.4 ± 7.1 years) who visited the hospital for physical examination were recruited for this study.…”