Comparison of Efficacy and Antibody Levels among Healthcare Providers after Second Dose of Two Different COVID Vaccines

Abstract

The ongoing COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in significant death and morbidity rates around the globe. SARS-CoV-2 infection has been linked to 43.3 million confirmed cases worldwide, killing 1.15 million people. Physical separation, quarantine, and isolation were successful in minimizing the number of individuals who became sick during the epidemic, but the lack of immunity in the community makes them vulnerable to further waves of SARS-CoV-2 infection. Elderly persons (those 60 and older) and those with pre-existing medical problems are particularly vulnerable.
 Material and Methods: In this observation study, people who were vaccinated with sinopharm vaccine and sinovac vaccine were included to see the response of vaccine in the body. The aim of the study was to compare the rise in the antibody level after 2 doses of two different COVID-19 vaccines i.e sinopharm and sinovac. Initially, in this pilot study, 40 people were included randomly from our health care team, after proper informed consent regarding the study.
 Results: Among total 40 people were involved, male were 21 of 40 (52.5%) and female were 19 of 40 (47.5%). Most of the individuals were doctors (26 of 40, 65%). Mean age, weight, height and body mass index (BMI) are also shown below.
 Conclusion: This study was to report the response of people of Pakistan toward sinopharm and sinoVac vaccines in terms of COVID antibody level. Response of the body was around 40 to 50% for sinopharm and 50 to 70 percent towards CoronaVac vaccine. Further data collection is being done to improve sample size and better outcome.

Review of Different Vaccines and Vaccination Campaings against Covid around the Globe and India

“…Longer prothrombin time and elevated D-dimer values were observed in the patients admitted in Intensive Care Unit (ICU's). Patients with comorbidities like hypertension, cardiovascular diseases and diabetes have a more fatal course of illness [2]. The S-protein, a key trimeric envelope glycoprotein produced on the virus's surface, is the major target protein for the vaccines as it is responsible for buildup of virus inside host cell by attaching to it.…”