Comparison of efficacies of vegetable oil based and polyethylene glycol based bisacodyl suppositories in treating patients with neurogenic bowel dysfunction after spinal cord injury: A meta-analysis

Zhu, Yichao; Cheng, Jie; Zhang, Wenyi; Xie, Baohua; Hong-zhu, Jin

doi:10.5152/tjg.2014.6708

Cited by 12 publications

(6 citation statements)

References 26 publications

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“…Moreover, an excessive intake of food may affect the normal intestinal function. Thus, an appropriate dietary management is needed for patients with SCI [30–32]. …”

Section: Discussionmentioning

confidence: 99%

Effects of Electroacupuncture on the Daily Rhythmicity of Intestinal Movement and Circadian Rhythmicity of Colonic Per2 Expression in Rats with Spinal Cord Injury

Cheng

Wang

Guo

et al. 2016

BioMed Research International

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Background. Spinal cord injury (SCI) leads to bowel dysfunction. Electroacupuncture (EA) may improve bowel function. Objective. To assess EA on daily rhythmicity of intestinal movement and circadian rhythmicity of colonic Per2 expression in rats with SCI. Methods. Rats were randomized to the sham, SCI, and SCI+EA groups. EA was performed at bilateral Zusanli point (ST36) during daytime (11:00–11:30) for 14 days following SCI. Intestinal transit and daily rhythmicity of intestinal movement were assessed. Circadian rhythmicity of colonic Per2 expression was assessed by real-time RT-PCR. Results. EA shortened the stool efflux time and increased the dry fecal weight within 24 h in SCI rats. Daily rhythmicity of intestinal movements was unaffected by SCI. The expression of colonic Per2 peaked at 20:00 and the nadir was observed at 8:00 in the SCI and sham groups. In the SCI+EA group, colonic Per2 expression peaked at 12:00 and 20:00, and the nadir was observed at 8:00. Conclusion. SCI did not change the circadian rhythmicity of colonic Per2 expression in rats, and daily intestinal movement rhythmicity was retained. EA changed the daily rhythmicity of intestinal movement and the circadian rhythmicity of colonic Per2 expression in rats with SCI, increasing Per2 expression shortly after EA treatment.

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“…Moreover, an excessive intake of food may affect the normal intestinal function. Thus, an appropriate dietary management is needed for patients with SCI [30–32]. …”

Section: Discussionmentioning

confidence: 99%

Effects of Electroacupuncture on the Daily Rhythmicity of Intestinal Movement and Circadian Rhythmicity of Colonic Per2 Expression in Rats with Spinal Cord Injury

Cheng

Wang

Guo

et al. 2016

BioMed Research International

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“…The use of rectal stimulants or digitation can be employed. Bisacodyl suppositories act as rectal stimulants, having a very rapid onset of action as shown in patients with a spinal cord injury 70…”

Section: Methodsmentioning

confidence: 99%

Neurogenic bowel dysfunction in patients with multiple sclerosis: prevalence, impact, and management strategies

Preziosi¹,

Gordon–Dixon²,

Emmanuel³

2018

DNND

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Bowel dysfunction in patients with multiple sclerosis (MS) is highly prevalent. Constipation and fecal incontinence can coexist and alternate, impacting on the patient’s quality of life and social interactions, as well as burdening the caregivers. The cost for the health care providers is also significant, with increased number of hospital admissions, treatment-related costs, and hospital appointments. The origin is multifactorial, and includes alteration of neurological pathways, polypharmacy, behavioral elements, and ability to access the toilet. Every patient with MS should be sensitively questioned about bowel function, and red flag symptoms should prompt adequate investigations. Manipulation of life style factors and establishment of a bowel regime should be attempted in the first place, and if this fails, other measures such as biofeedback and transanal irrigation should be included. A stoma can improve quality of life, and is not necessarily a last-ditch option. Antegrade colonic enemas can also be an effective option, whilst neuromodulation has not proved its role yet. Effective treatment of bowel dysfunction improves quality of life, reduces incidence of urinary tract infection, and reduces health care costs.

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“…Recent research studies have been conducted on the beneficial aspects of PEG as a tissue-compatible reagent for the prevention of adhesion after laminectomy [ 24 ] and as a carrier of regeneration-prompting molecules in spinal cord injuries [ 25 ]. The oral administration of PEG in patients suffering from spinal injuries has also been noted in the setting of bowel preparation for colonoscopy [ 26 ] and the treatment of neurological bowel dysfunction after spinal cord injuries [ 27 ]. Our results support the administration of PEG for bowel evacuation to decrease the volume of intraoperative bleeding during spinal surgeries and to decrease the need for blood transfusion.…”

Section: Discussionmentioning

confidence: 99%

Preoperative Mechanical Bowel Evacuation Reduces Intraoperative Bleeding and Operation Time in Spinal Surgery

et al. 2018

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Study DesignRandomized clinical trial.PurposeIn this study, we evaluated the effect of mechanical evacuation of the bowels prior to operation on intraoperative bleeding.Overview of LiteratureBleeding is the most significant complication in patients undergoing spinal surgery.MethodsWe randomly divided 108 individuals planned to undergo spinal surgery into two age-, sex-, and co-morbidity (especially preoperative hemoglobin [Hb])-matched groups of 54. The treatment group was administered polyethylene glycol (PEG) before the operation, whereas the control group was not. The exact amount (mL) of bleeding during operation, operative time, and approximate amount of blood transfused were recorded. The volume of bleeding and Hb level were also recorded 24 and 48 hours postoperatively.ResultsT-tests revealed that intraoperative bleeding, the volume of transfusion, and operative time were significantly lower in the treatment group than in the control group. Statistically significant correlations of intraoperative bleeding with age, body mass index (BMI), preoperative Hb levels, operative time, the volume of transfusion, hospitalization time, and 24- and 48-hour postoperative bleeding were observed (p =0.001, all). Repeated measures analysis of covariance after adjusting the covariate variables revealed that the volume of bleeding showed a near-significant trend in the treatment group compared with that in the control group (p =0.056). Diabetic females had the highest bleeding amount between the groups (p =0.03). Bleeding was higher in patients with higher BMI (p =0.02) and was related to operative time (p =0.001) in both the groups.ConclusionsPreoperative gastrointestinal tract evacuation by PEG administration can decrease intraoperative bleeding in spinal surgeries; however, more research is imperative regarding PEG administration in surgical procedures for this purpose.

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Comparison of efficacies of vegetable oil based and polyethylene glycol based bisacodyl suppositories in treating patients with neurogenic bowel dysfunction after spinal cord injury: A meta-analysis

Cited by 12 publications

References 26 publications

Effects of Electroacupuncture on the Daily Rhythmicity of Intestinal Movement and Circadian Rhythmicity of Colonic Per2 Expression in Rats with Spinal Cord Injury

Effects of Electroacupuncture on the Daily Rhythmicity of Intestinal Movement and Circadian Rhythmicity of Colonic Per2 Expression in Rats with Spinal Cord Injury

Neurogenic bowel dysfunction in patients with multiple sclerosis: prevalence, impact, and management strategies

Preoperative Mechanical Bowel Evacuation Reduces Intraoperative Bleeding and Operation Time in Spinal Surgery

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