Comparison of effects of thyroidectomy with propylthiouracil treatment on renal hypertension in rats

Fregly, Melvin J.; Baker, M. I.; Gennaro, Joseph F.

doi:10.1152/ajplegacy.1960.198.1.4

Cited by 9 publications

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“…Fregly 22 reported that SHR had lower l3l I-uptake by the thyroid gland than normotensive control animals. However, thyroidectomy or administration of propylthiouracil prevented the expected rise in BP, both in renal hypertension 23 and in NaCl-induced hypertension in rats. 24 Serum T 4 concentrations are lower in the prehypertensive stage of SHR, but thyroidectomy at this stage prevents the later development of hypertension.…”

Section: Resultsmentioning

confidence: 93%

“…24 Serum T 4 concentrations are lower in the prehypertensive stage of SHR, but thyroidectomy at this stage prevents the later development of hypertension. 23 These observations in SHR were made in relation to the systolic BP. If they have any bearing on the pathogenesis of hypertension in humans, they may be more related to isolated systolic hypertension, such as that seen in 20% of our thyrotoxic patients, than to diastolic hypertension.…”

Section: Resultsmentioning

confidence: 99%

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Effects of thyroid function on blood pressure. Recognition of hypothyroid hypertension.

et al. 1988

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SUMMARY Hypothyroid ism has been known to be associated, at times, with diastolic hypertension. We have found in 40 thyrotoxic patients that the induction of hypothyroid ism by radioiodine therapy significantly increased diastolic blood pressure, raising it above 90 mm Hg in 16 (40%) of the patients. Restoration of euthyroidism with thyroxine administration significantly reduced the systolic and diastolic blood pressures in these patients, with a fall in diastolic pressure below 90 mm Hg in nine of 16 patients. The prevalence of hypothyroid ism was determined by measurements of serum thyroxine and thyrotropin concentrations in 688 consecutive hypertensive patients, referred for evaluation and therapy of their hypertension. Hypothyroidism was found in 25 (3.6%) of the patients. Restoration of normal serum thyroxine and thyrotropin levels with thyroid hormone replacement therapy lowered diastolic blood pressure to levels below 90 mm Hg in 32% of these patients who could be followed up after withdrawal of all antihypertensive drug therapy when euthyroidism had been restored (i.e., 1.2% of the 688 patients). It is concluded that diastolic hypertension resulting from hypothyroidism is a relatively common disorder, present in 1.2% of our referred hypertensive patients, that should be sought and treated. (Hypertension 11: 78-83, 1988) KEY WORDS • hypothyroid hypertension • endocrine hypertension • thyroid in hypertension H YPERTHYROIDISM is usually associated with peripheral vasodilatation and reduction of the diastolic blood pressure (BP) and sometimes with systolic hypertension, while hypothyroidism may be accompanied by diastolic hypertension, as many clinicians are aware. Elevation of the diastolic BP was found to be common in patients with hypothyroidism 1 and has been reported in small groups of patients with hypothyroidism and myxedema by several investigators, 2 " 6 who have all found a fall in diastolic BP when the hypothyroidism was corrected with thyroid replacement therapy. The latter observations were preceded by a report that desiccated thyroid administration lowered the BP to normal levels in 14% of 334 patients with essential hypertension, at a time (in 1950) when virtually no effective forms of antihypertensive therapy were available. Received February 11, 1987; accepted August 13, 1987. were reported by Fuller et al. 2 However, in a comparison of BP measurements in 80 hypothyroid patients and 73 euthyroid subjects, Endo et al. 8 found no evidence that hypothyroidism predisposed to hypertension. Apart from this negative study, there have been no recent attempts to determine the frequency with which hypertension may be associated with and caused by hypothyroidism, the treatment of which will restore the BP to normal. We have sought to obtain this information 1) by studying the BP responses of a series of patients with thyrotoxicosis to therapy with radioiodine as they became euthyroid and, frequently, hypothyroid and during correction of the iatrogenic hypothyroidism with thyroxine therapy and 2) ...

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Effects of thyroid function on blood pressure. Recognition of hypothyroid hypertension.

et al. 1988

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The thyroid in the spontaneously hypertensive rat: A light and electron microscopic study

et al. 1977

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The present study was undertaken to seek ultrastructural changes in the thyroid gland of the spontaneously hypertensive rat which would contribute to the understanding of previously reported abnormalities in thyroid function. Light and electron microscopic observations and measurements of plasma T3 and systolic blood pressure were recorded from a colony of Wistar Kyoto rats (WKY) and of spontaneously hypertensive rats (SHR). The systolic blood pressure of SHR was significantly higher than that of WKY but the plasma T3 levels of the two groups did not differ significantly. After administration of propylthiouracil (PTU), serum T3 levels and systolic pressure of both groups decreased. The size of the thyroid follicles in SHR was highly variable throughout the gland, and the colloid contained unevenly dense areas and cell debris. The follicular cells contained slightly dilated rough surfaced endoplasmic reticulum (ER) and numerous pleomorphic bodies of uneven density. After treatment with PTU, the vessels between the follicles of SHR did not become as dilated as those in WKY but the fine structure of follicular cells in SHR was similar to that of WKY and was characteristic of the typical thyroid response to PTU administration. We suggest that the thyroid in SHR does not respond adequately to the elevated TSH levels reported to be present in these animals, although it can respond to the highly elevated TSH levels which occur with PTU administration. This impairment most probably involves defects in synthesis and/or secretion of thyroid hormones in response to TSH stimulation.

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Physiologie und Pathologie des Renin/Angiotensin-Systems

Gross¹

1968

Nierenkrankheiten

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Comparison of effects of thyroidectomy with propylthiouracil treatment on renal hypertension in rats

Cited by 9 publications

References 0 publications

Effects of thyroid function on blood pressure. Recognition of hypothyroid hypertension.

Effects of thyroid function on blood pressure. Recognition of hypothyroid hypertension.

The thyroid in the spontaneously hypertensive rat: A light and electron microscopic study

Physiologie und Pathologie des Renin/Angiotensin-Systems

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