Comparison of Effects of Prolonged Aldosterone Administration on Rat Colon and Renal Electrolyte Excretion

Thompson, B. D.; Edmonds, C. J.

doi:10.1677/joe.0.0500163

Cited by 24 publications

(9 citation statements)

References 9 publications

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“…An initially depresed urinary Na+ excretion has also been reported in intact rats given a continuous infusion of aldosterone for up to 16 days (240 ,ug/day), but 'escape' again occurred after about 4 days (Thompson & Edmonds, 1971). Such an 'escape phenomenon' might explain the short duration (6 h) of the effects observed in our animals.…”

Section: A Safwate Renal Response Of Very Young Calves To Aldosteronsupporting

confidence: 77%

Urinary sodium excretion and the renin‐aldosterone system in new‐born calves.

Safwate¹

1985

The Journal of Physiology

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SUMMARY1. Urinary Na+ and K+ excretion, plasma aldosterone levels (PAL) and plasma renin activity (PRA) were measured in three groups of four 3-day-old calves infused with aldosterone, ethacrynic acid and hydrochlorothiazide or with vehicle.2. Aldosterone infusion (16-7 jug/kg body wt. given by rapid injection, followed by the infusion of 33-3 jug/kg body wt. during 6 h) decreased urinary Na+ concentration and excretion during the 6 h period of infusion. This effect disappeared during the following 18 h.3. Ethacrynic acid (2 mg/kg body wt. by rapid injection, followed by the infusion of 1-5 mg/kg body wt. . h during 6 h) and hydrochlorothiazide (8 mg/kg body wt. by rapid injection, followed by the infusion of 6 mg/kg body wt. . h during 6 h) increased urinary volume and urinary excretion ofNa+, but decreased urinary K+ concentration without affecting urinary K+ excretion during the 6 h period of infusion. During the same time-, the plasma Na+ concentration decreased, PRA increased rapidly and was followed by a significant rise in PAL.4. These results demonstrate that in very young healthy calves, the renal tubules are able to respond to aldosterone. The renin-aldosterone system is also operative in these animals since it responds to Na+ depletion induced by the combination of diuretics and inhibitors of tubular Na+ reabsorption.

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Section: A Safwate Renal Response Of Very Young Calves To Aldosteronsupporting

confidence: 77%

Urinary sodium excretion and the renin‐aldosterone system in new‐born calves.

Safwate¹

1985

The Journal of Physiology

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“…Various observations however, suggest that this is unlikely. Thus aldosterone given to rats or to normal men over several days effectively lowers the sodium concentration in the faecal water without the necessity of giving angiotensin in addition (Charron, Leme, Wilson, Ing & Wrong, 1969;Thompson & Edmonds, 1971). Furthermore, in patients with hyperaldosteronism resulting from an adrenal tumour or hyperplasia, aldosterone retains its effect on the colon despite very low plasma renin and angiotensin levels (Milne, Muehrcke & Aird, 1957;Richards, 1969).…”

Section: Effect On Ionic Fluxesmentioning

confidence: 99%

The effect of aldosterone and the renin‐angiotensin system on sodium, potassium and chloride transport by proximal and distal rat colon in vivo.

Dolman¹,

Edmonds²

1975

The Journal of Physiology

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SUMMARY1. The roles of aldosterone and angiotensin in the direct control of epithelial sodium transport in vivo have been investigated by measurement of electrical p.d. changes and of the fluxes of sodium, potassium and chloride in rat colon, an organ actively involved in electrolyte homoeostasis. Exogenous angiotensin and aldosterone were given by both short-and long-term infusions and endogenous secretion of the hormones was varied by dietary sodium variation and by nephrectomy and/or adrenalectomy.2. In vitro angiotensin has been shown to influence colonic salt and water absorption but in the present in vivo experiments administered angiotensin had no significant action on p.d. or on the ionic fluxes of the proximal or distal colon. The increase in p.d. produced by infusing aldosterone was unaffected by giving angiotensin concurrently. The effect of sodium depletion in stimulating sodium absorption and potassium secretion was completely abolished by adrenalectomy but was unaffected by nephrectomy.3. During prolonged infusion of angiotensin into adrenalectomized rats, a small fall in faecal fluid and sodium content was observed, but this change would have little significance in sodium homoeostasis.4. Aldosterone and sodium depletion stimulated sodium absorption in both proximal and distal colon but significant increase in potassium secretion was demonstrable only in the distal colon. Bicarbonate secretion (by calculation) was unaffected. In the proximal colon, the increased sodium absorption appeared to be accompanied by increased chloride absorption while in the distal colon it was principally the sodium-potassium exchange that was increased.

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“…If aldosterone continued to stimulate sodium reabsorption distally, the rise in potas¬ sium excretion in exchange would be expected. Actions of aldosterone at other sites may not be modulated by prolactin-like hormones since rat colon does not appear to show the escape phenomenon (Thompson & Edmonds, 1971).…”

Section: Discussionmentioning

confidence: 98%

Saluretic Action of Aldosterone in the Presence of Increased Salt Intake and Restoration of Normal Action by Prolactin or by Oxytocin

Burstyn¹,

Horrobin²,

Manku³

1972

Journal of Endocrinology

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SUMMARY The effects of aldosterone on sodium, potassium and water excretion during various treatment regimes were studied in six Merino ewes. Urine was collected from 12.00 to 14.00 h and from 14.00 to 16.00 h each day. Intravenous injections of either 1 ml isotonic saline or 500 μg aldosterone were given at 13.30 h and excretion during the second collection period compared with that in the first. When each animal was given a salt (NaCl) supplement of 80 mequiv./day by i.v. injection, aldosterone caused marked sodium retention with no effect on potassium. When salt supplements of 400 mequiv./day were given, aldosterone lost its sodium-retaining action in all animals and caused a marked saluresis with a small increase in potassium excretion in five sheep out of six. Injections of sheep pituitary prolactin or of oxytocin restored the sodium-retaining action of aldosterone in spite of a continued high salt intake. The animals gained very little weight when treated with 400 mequiv. salt alone but did gain significantly when treated with salt plus prolactin. The weight gain was rapidly lost when the prolactin and high salt intake were discontinued.

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Comparison of Effects of Prolonged Aldosterone Administration on Rat Colon and Renal Electrolyte Excretion

Cited by 24 publications

References 9 publications

Urinary sodium excretion and the renin‐aldosterone system in new‐born calves.

Urinary sodium excretion and the renin‐aldosterone system in new‐born calves.

The effect of aldosterone and the renin‐angiotensin system on sodium, potassium and chloride transport by proximal and distal rat colon in vivo.

Saluretic Action of Aldosterone in the Presence of Increased Salt Intake and Restoration of Normal Action by Prolactin or by Oxytocin

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