1977
DOI: 10.1007/bf02012775
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Comparison of effects of parathyroidectomy and ethane-1-hydroxy-1,1-diphosphonate (EHDP) administration upon bone synthesis of hydroxyproline and urinary excretion of hydroxyproline in rats

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Cited by 5 publications
(3 citation statements)
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“…Collagen catabolism is depressed to a greater extent than collagen synthesis s47). These findings are in accord with other investigations s3s' s42, [545][546][547]. Osteoclast population parameters are increased with both C12MDP and EHDP with CI2MDP having a greater effect than similar doses of EHDP s48).…”
Section: Effects Of Diphosphonates On Calcificationsupporting
confidence: 91%
“…Collagen catabolism is depressed to a greater extent than collagen synthesis s47). These findings are in accord with other investigations s3s' s42, [545][546][547]. Osteoclast population parameters are increased with both C12MDP and EHDP with CI2MDP having a greater effect than similar doses of EHDP s48).…”
Section: Effects Of Diphosphonates On Calcificationsupporting
confidence: 91%
“…Urinary cyclic AMP was also measured on day 10, as an index of parathyroid function (Goulding 1980). In order to measure the bone synthesis of 3 H-hydroxyproline, rats were given labelled proline (L-proline-2,3-3 H, New England Nuclear Corporation, 30 Ci/mmol) by intraperitoneal injection (150 nCi/kg body wt in 1.0 ml 0.9% NaCI) 24 hours before they were killed (Goulding and McChesney 1977). The left femur was then taken for mineral analysis (Goulding and Campbell 1984) and the right femur for hydroxyproline measurement.…”
Section: Methods Experiments 1 Effects Of Salt On Femoral 3 H-hydroxymentioning
confidence: 99%
“…Hydroxyproline was measured by the method of Bergman and Loxley (1970). Tritiated hydroxyproline in bone was separated from 3 H-proline on Dowex X-100 as described previously (Goulding and McChesney 1977). Radioactivity was measured on an LKB Rackbeta II Model 1214 liquid scintillation counter and samples were corrected for quenching.…”
Section: Chemical Analysismentioning
confidence: 99%