Comparison of effects of hepatitis E or A viral superinfection in patients with chronic hepatitis B

Zhang, Xiaohong; Ke, Wei-Min; Xie, Jun; Zhao, Zhigang; Xie, Dongying; Gao, Zhiliang

doi:10.1007/s12072-010-9204-4

Cited by 52 publications

(60 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mortality rate ranges from 0% to 67% with a median being 34%. In the Chinese study by Zhang et al, 27 46 of 136 (34%) patients of HEV-ACLF had succumbed to liver failure. While in the two of the large studies from India the mortality rate was about 44%.…”

Section: Clinical Features and Prognosis Of Hev-related Aclfmentioning

confidence: 97%

“…17 Subsequently, many publications have reported HEV as one of the leading causes for decompensation of cirrhosis from Asia and Africa, where HEV is endemic (Table 1). 14,15,[17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] Most of these studies have used the APASL definition of ACLF and in median21% of cases (range 4-72%) of ACLF, HEV was the precipitating cause for liver decompensation. This contrasts with the Western countries where HEV is rarely the precipitating cause of acute decompensation in ACLF.…”

Section: Role Of Hepatitis E Virus In Acute-on-chronic Liver Failurementioning

confidence: 99%

“…27 The authors compared the demographics, liver function, and prognosis of Chinese patients infected with chronic hepatitis B (CHB) and superinfected with HEV or hepatitis A virus (HAV). Among 188 patients with CHB, 136 had HEV superinfection and 52 had HAV superinfection.…”

Section: Role Of Hepatitis E Virus In Acute-on-chronic Liver Failurementioning

confidence: 99%

“…In 75% patients the acute and chronic insult had same etiology (alcohol or hepatitis B), whilst in 25% patients the etiology of chronic and acute insults were different from each other and in these patients, 61% had hepatitis E viral infection as acute insult. 31 In the study by Radha Krishna et al 26 which had maximum patients of HEV-related ACLF (HEV-ACLF) from India (80 out of 121 [66%] patients of ACLF), the 26 Zhang et al 27 from China, compared the effects of HEV superinfection with HAV superinfection in their cohort of patients with chronic hepatitis B. In contrast to other smaller studies which could not discern any difference in presentation among ACLF of different etiologies, Zhang et al were able to show that HEV-ACLF was indeed a more severe illness than HAV-ACLF.…”

Section: Clinical Features and Prognosis Of Hev-related Aclfmentioning

confidence: 99%

See 3 more Smart Citations

Hepatitis E and Acute-on-Chronic Liver Failure

Kumar

Saraswat

2013

Journal of Clinical and Experimental Hepatology

View full text Add to dashboard Cite

Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis (AVH) globally. It causes large scale epidemics of AVH across the low-and middle income countries in Asia and Africa, and also causes sporadic cases of AVH in the same geographical region. AVH due to HEV is usually an acute, self-limiting illness, similar in clinical presentation to AVH caused by hepatitis A virus (HAV). When HEV causes AVH in patients of chronic liver disease it may worsen rapidly to a syndrome called acute-on-chronic liver failure (ACLF) leading to very high mortality. Acute deterioration of liver function in a patient with compensated chronic liver disease is the characteristic feature of ACLF. The typical disease course of patients with ACLF is the appearance of organ failure, which progresses to multi-organ failure and death. Many publications have reported HEV as one of the leading causes for ACLF from Asia and Africa, where HEV is endemic. The mortality rate of HEV-related ACLF (HEV-ACLF) ranges from 0% to 67% with a median being 34%. These patients require admission in the intensive care unit and they benefit from a team approach of clinicians with expertise in both hepatology and critical care. The goals of treatment are to prevent further deterioration in liver function, reverse precipitating factors, and support failing organs. Liver transplantation is required in selected patients to improve survival and quality of life. One preliminary report suggests that ribavirin may be an effective and safe drug for treatment of HEV-ACLF however this requires validation in large trials. ( J CLIN EXP HEPATOL 2013;3:225-230)

show abstract

Section: Clinical Features and Prognosis Of Hev-related Aclfmentioning

confidence: 97%

Section: Role Of Hepatitis E Virus In Acute-on-chronic Liver Failurementioning

confidence: 99%

Section: Role Of Hepatitis E Virus In Acute-on-chronic Liver Failurementioning

confidence: 99%

Section: Clinical Features and Prognosis Of Hev-related Aclfmentioning

confidence: 99%

See 2 more Smart Citations

Hepatitis E and Acute-on-Chronic Liver Failure

Kumar

Saraswat

2013

Journal of Clinical and Experimental Hepatology

View full text Add to dashboard Cite

show abstract

“…Decompensation of preexisting cirrhosis as well as increased morbidity and mortality has been reported for HEV1 superinfection among patients with chronic hepatitis C (5). Progression of chronic hepatitis to fulminant hepatitis and cirrhosis due to HCV H Sero-Epidemiology of Hepatitis E in HCV patients infection may be caused by HEV coinfections or other hepatitis agents (6,7). Severe response of the immune system to hepatitis viruses and direct cytopathic effect of HEV can cause liver fibrosis progression and cirrhosis (8).…”

Section: Introductionmentioning

confidence: 99%

Sero-Epidemiology of Hepatitis E Infections in patients with chronic Hepatitis C virus infection in Jahrom, Southern Iran

et al. 2016

View full text Add to dashboard Cite

Background and Aims: Co-infection of hepatitis E virus (HEV) in chronic hepatitis C virus (HCV) infected patients can develop and cause an increase in liver disease and hepatic complications in the world. The purpose of this study was to assess the prevalence of HEV infection in patients suffering from chronic HCV infection. Materials and Methods: Cross-sectional study testing anti-HEV antibodies in serum samples belonged to 53 chronic HCV infected patients were evaluated. Demographic and clinical data such as liver function tests and enzymes level were prospectively collected on each patient with chronic HCV infection. Results: There were 5 HEV infected patients IgG positive among the 53 chronic HCV infected patients. These patients had an alanine aminotransferase (ALT) level twice the upper level about of the 48 HEV negative patients (p<0.0001). Conclusions: Prevalence of HEV sero-positivity patients with HCV co-infection patients was 9.4%. Our results suggest that HEV screening should be implemented in HCV-infected patients with cancer.

show abstract

Clinical analysis of patients suffering from chronic hepatitis B superinfected with other hepadnaviruses

Jun

Guo

Gao

et al. 2015

Journal of Medical Virology

View full text Add to dashboard Cite

To compare the clinical manifestations, laboratory examinations, and prognoses of patients with chronic hepatitis B (CHB) who were superinfected with hepatitis A virus (HAV), hepatitis C virus (HCV), hepatitis D virus (HDV), or hepatitis E virus (HEV). Two hundred and eleven patients with confirmed CHB in our hospital, a tertiary teaching hospital in China, between 2005 and 2014 were analyzed retrospectively. Among 211 patients with CHB, 35 were superinfected with HAV, 31 were superinfected with HCV, 22 were superinfected with HDV, and 53 were superinfected with HEV. We analyzed and compared the clinical features of the five groups. The tested biochemical indices and markers of liver function included serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBil), prothrombin activity (PTA), serum albumin (Alb), and the serum levels of HBV DNA. The peak values of ALT, AST, and TBil were significantly higher in all of the superinfected groups. Lower peak Alb concentration and PTA were also observed in the superinfected patients, with the exception of patients in the CHB + HAV group. The CHB + HCV, and CHB + HEV groups had higher death rates than the CHB monoinfected group, and the difference was statistically significant. Further analysis of the liver failure groups showed that the level of HBV DNA was not correlated with prognosis. The comparison of clinical outcomes revealed that CHB patients superinfected with HCV, HDV, and HEV compared with CHB monoinfection had statistically greater incidences of exacerbation of the condition and poor prognosis, whereas the patients superinfected with HAV generally had better outcomes.

show abstract

Comparison of effects of hepatitis E or A viral superinfection in patients with chronic hepatitis B

Cited by 52 publications

References 6 publications

Hepatitis E and Acute-on-Chronic Liver Failure

Hepatitis E and Acute-on-Chronic Liver Failure

Sero-Epidemiology of Hepatitis E Infections in patients with chronic Hepatitis C virus infection in Jahrom, Southern Iran

Clinical analysis of patients suffering from chronic hepatitis B superinfected with other hepadnaviruses

Contact Info

Product

Resources

About