Comparison of effects of electrical stimulation of preoptic area, anterior hypothalamus and dorsal raphe nucleus on 5-hydroxyindoleacetic acid in cerebrospinal fluid and behavior

Radulovački, Miodrag; Karmos, G.

doi:10.1016/0006-8993(74)90503-4

Cited by 8 publications

(1 citation statement)

References 10 publications

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“…but the clearest reduction of vigilance was observed at 2 Hz [27]. Stimulation of 5-HT nerve endings contained in the anterior hypothalamus even caused excitation [34]. In rats, intraperitoneal injection of tryptophan at a dose of 30 mg/kg decreased the latency to the first SWS and PS episode, but 120 mg/kg increased waking and decreased PS [48], With respect to the role of 5-HT in sleep and waking these conflicting results could be explained by the exis tence of a vigilance-controlling apparatus (VCA), re cently proposed by Koella [24], which extended the vigi lance concept of Bente [1] by including sleep.…”

Section: Introductionmentioning

confidence: 97%

Effects of the Selective 5-Hydroxytryptamine Uptake Inhibitors Paroxetine and Zimeldine on EEG Sleep and Waking Stages in the Rat

Kleinlogel¹,

Bürki²

1987

Neuropsychobiology

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The effects of oral paroxetine and zimeldine on EEG sleep-waking phases in the rat were investigated over a wide dose range. To ascertain that at the doses used for the EEG studies paroxetine and zimeldine selectively affect the serotoninergic system, their effects on brain 5-hydroxytryptamine (5-HT), dopamine and noradrenaline were determined. It was found that paroxetine and zimeldine at doses of 1–18 mg/kg dose-dependently prolonged waking and shortened slow-wave sleep and paradoxical sleep. In the same dose range cortical 5-HT turnover was significantly reduced, whereas the other aminergic systems were not influenced. These results suggest that 5-HT uptake inhibitors increase vigilance in rats at oral doses which selectively stimulate the serotoninergic system.

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