Comparison of effectiveness and survival after the MitraClip or Carillon procedure for severe functional mitral regurgitation: a single-center retrospective analysis

Abstract

Introduction Current studies suggest improved survival in patients with severe functional mitral regurgitation (FMR) treated successfully with the MitraClip (MC) compared to medical treatment alone, in addition to a significant reduction of FMR severity. Recently, the Carillon system (CS) has also been shown to significantly reduce FMR. However, whether this beneficial effect of CS also translates into a survival benefit comparable to the MC system has not been investigated so far. The aim of the study was to compare the course of FMR grade and mortality after MC or CS in a retrospective, non-randomized, single-center analysis. Material and methods A hundred and fifty-four patients with symptomatic FMR 2+ were included in this study (MC: n = 117, CS: n = 37). Baseline characteristics did not differ significantly between groups. Results and conclusions Initially, the degree of FMR was reduced in the MC group from 2.9 ±0.3 to 1.7 ±0.7 and from 2.7 ±0.5 to 2.1 ±0.7 in the CS group, p within and between groups < 0.01. Within 6 months, FMR remained reduced in the MC group (1.83 ±0.6) and CS group (2.1 ±0.7). One-year survival was 34.8% in the MC group and 54.8% in the CS group ( p = 0.663). Median long-term survival was 1.66 years in the MC group and 3.92 years in the CS group, log rank p = 0.001.

Mitral valve edge‐to‐edge repair versus indirect mitral valve annuloplasty in atrial functional mitral regurgitation

“…A recent publication compared both therapeutic approaches in vFMR in which patients treated with the MitraClip had a reduced degree of FMR from initially 2.9 ± 0.3–1.7 ± 0.7 compared to 2.7 ± 0.5–2.1 ± 0.7 in the Carillon group. Of note, results were significant within and between groups 24 …”

“…were significant within and between groups. 24 Recently indirect mitral annuloplasty provided evidence to induce annular and atrial remodeling in patients with vFMR. 23 We confirmed the previously published results for indirect mitral valve annuloplasty, which demonstrated a reduction in LA volume of 13% after 12-months.…”