Comparison of effect of intra socket ketamine and tramadol on postoperative pain after mandibular third molar surgery

Abstract

Aim: This study compared the analgesic efficacy of intra socket application of tramadol versus ketamine for preventing pain after mandibular third molar surgery. Materials and Methods: Thirty patients who had undergone third molar surgery were randomly divided into three groups: Group T (tramadol 1 mg/kg), Group K (ketamine 0.5 mg/kg), and Group C (saline 2 mL). The treatment was applied to the extraction sockets using resorbable gel foam. Average time taken for the procedure was recorded. Pain was evaluated postoperatively using a visual analog scale (VAS) at 6 and 24 h postoperatively. Furthermore, the number of analgesics taken in the 1 st 24 h was recorded. The relevant information was gathered and tabulated. IBM SPSS 2.0 was used to analyze the results and one-way ANOVA test was used to determine the statistical significance. Results: The VAS scores after extraction were statistically higher in Group C than in either treatment group. Group K had the lowest pain intensity. During the 1 st 6 h, patients reported statistically lower pain intensity scores in Groups K and T versus Group C. At 24 h, Group K had the lowest pain intensity and Group T had less pain than Group C. The number of analgesics taken in the 1 st 24 h was highest in Group C. Conclusion: This study shows that intra socket use of tramadol and ketamine can be used as effective alternatives for decreasing pain after third molar surgery.

A Clinical Study for Removal of Impacted Mandibular Third Molar under Local Anaesthesia, with and without Ketamine - A Split Mouth Comparative Study

“…The NMDA receptors are initially usually loaded with magnesium, but persistent nociceptive afferent stimulation from the periphery (or surgical site) will cause membrane depolarisation to remove this magnesium inhibition from the NMDA receptors. [ 13 ] The excitatory neurotransmitter glutamate binds to the NMDA receptors as a result, sending pain signals to the brain. As a result, the wound is repeatedly stimulated, which is made possible by the NMDA receptors, and this results in a state of hyperalgesia or lowered pain sensitivity threshold (also known as the windup phenomenon).…”

Post-operative pain management using two drugs following dental implant surgery among Indians

“…Approval of the study protocol and ethical clearance were obtained from the Institutional Review Board, Saveetha Dental College Hospitals, Chennai, India and were within the statutory limitations of the Revised Helsinki Declaration of World Health Organization 2013. The study design as described elsewhere [ 7 , 8 , 9 , 10 , 11 , 12 , 13 ].…”