Comparison of effect of daily versus weekly iron supplementation during pregnancy on lipid peroxidation

Bhatla, Neerja; Kaul, Nivedita; Lal, Neena; Kriplani, Alka; Agarwal, Nutan; Saxena, Renu; Gupta, Suresh

doi:10.1111/j.1447-0756.2008.00972.x

Cited by 31 publications

(36 citation statements)

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“…Similar results have been reported with 50 mg elemental Fe provided daily for 8 weeks during pregnancy (18) . Supplementing Fe to healthy, non-anaemic pregnant women has been reported to increase oxidative stress, resulting in deleterious effects on lipid peroxidation (19,20) as well as protein oxidation (18) . Some of these effects have been shown to be ameliorated by the concomitant consumption of antioxidants such as vitamin C (19) .…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress during early pregnancy and birth outcomes

Shastri

Pammal

Mani

et al. 2016

Public Health Nutr.

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Objective: Routine high-dose Fe supplementation in non-anaemic pregnant women may induce oxidative stress and eventually affect birth outcomes. The aim of the present study was to measure oxidative stress markers in pregnant women with low/normal and high Hb values in trimester 1 (Hb 1 ) and to relate these to birth weight. Design: A cross-sectional study where selected oxidative stress markers were analysed in both maternal (trimester 1; T1) and cord blood samples and correlated with birth weight. Setting: A tertiary hospital in urban South India. Subjects: One hundred women were chosen based on their Hb 1 values (forty women with low/normal Hb 1 (<110 g/l) and sixty women with high Hb 1 (≥120 g/l)). Results: In T1, women with high Hb 1 values were found to have lower paraoxonase-1 (PON-1) activity (424·7 (SD 163·7) v. 532·9 (SD 144·7) pmol p-nitrophenol formed/min per ml plasma, P = 0·002) and higher lipid peroxides compared with women with low/normal Hb 1 . Routine supplementation of Fe to these women resulted in persistent lower PON-1 activity in cord blood (P = 0·02) and directionally lower (P = 0·142) birth weights. Furthermore, women with high Hb 1 who delivered low-birth-weight babies were observed to have lowest PON-1 activity in T1. No changes were observed in other markers (myeloperoxidase activity and total antioxidant levels). Conclusions: Routine Fe supplementation in pregnant women with high Hb 1 associated with increased oxidative stress, as reflected by low PON-1 activity in T1, could potentially lead to deleterious effects on birth weight.

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Section: Discussionmentioning

confidence: 99%

Oxidative stress during early pregnancy and birth outcomes

Shastri

Pammal

Mani

et al. 2016

Public Health Nutr.

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“…8 It is speculated that nontransferrin bound iron (NTBI) in the blood 8,9 can affect the placenta by the release of reactive oxygen species leading to lipid peroxidation and DNA damage, resulting in outcomes such as intrauterine growth restriction, LBW, preterm delivery and SGA, as well as other complications. 8,[10][11] Adverse effects of high dose iron supplementation, like an increased risk of haemoconcentration at delivery and SGA, have been reported earlier in non-anaemic, iron-replete women, [12][13] such that the individualization of supplementation, rather than its generalization, is now suggested. 5,13 These effects have yet to be studied or reported in India, despite high supplemental iron intake in some parts of the country.…”

Section: Introductionmentioning

confidence: 99%

Association of oral iron supplementation with birth outcomes in non-anaemic South Indian pregnant women

et al. 2014

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“…Más aun, el administrar suplemento de hierro de manera diaria a gestantes no anémicas produce estrés oxidativo (19) y mayor peroxidación lipídica (20) .…”

Section: Hemoglobina Materna Y El Recien Nacidounclassified

Hemoglobina materna en la salud perinatal y materna en la altura: implicancias en la región andina

Gonzáles

2014

Rev Peru Med Exp Salud Publica

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RESUMENEsta revisión analiza la importancia del valor de la hemoglobina en la gestante, y su implicancia sobre el embarazo. Discute el uso de combustible de biomasa y la repercusión en el peso del recién nacido, los valores de hemoglobina materna y el riesgo de muerte fetal tardía, parto pretérmino y nacer pequeño para la edad gestacional. Asimismo, se aborda la necesidad de corregir el punto de corte de los valores de hemoglobina para definir anemia en la altura. La evidencia actual sugiere no corregirla, así también, la suplementación de hierro a las gestantes debería ser dirigida a los casos de anemia moderada o severa. Se discute si se debería reorientar la suplementación de hierro a niños de 6 a menos de 36 meses de edad Palabras clave: Recién nacido de bajo peso; Recién nacido pequeño para la edad gestacional; Anemia; Eritrocitosis; Muerte fetal (fuente: DeCS BIREME). MOTHER'S HEMOGLOBIN IN PERINATAL AND MOTHER HEALTH IN THE HIGHLANDS: IMPLICATIONS IN THE ANDEAN REGION ABSTRACTThis review analyzes the importance of hemoglobin levels in pregnant women and its implications in pregnancy.It discuss the use of biomass fuel for cooking and the impact on birthweight, maternal hemoglobin levels and the risk of late fetal death, pre-term delivery, and small for gestational age. Furthermore, the need to correct the cutoff points of hemoglobin level to define anemia at high altitudes is addressed. Current evidence suggests that corrections should not be made and iron supplements should be given to pregnant mothers with moderate or severe anemia. It is discussed whether iron supplementation should change its target population from pregnant women to infants aged 6 to 36 months. INTRODUCCIÓNEl Perú presenta características particulares en cada una de sus tres regiones geográficas. La vida en la sierra implica una serie de condiciones que la hacen diferente a lo que acontece en costa o selva. Entre ellos, el ambiente adverso y la pobreza condicionan el elevado uso de combustible de biomasa (leña, champa, bosta) para cocinar, lo cual produce gran contaminación dentro de las casas, agudiza el problema de la hipoxia e incrementa los niveles de hemoglobina (Hb) observados en la altura.Ello determina que la tasa de muerte fetal tardía (MFT), parto pretérmino, nacidos pequeños para edad gestacional (PEG), preeclampsia, y mortalidad neonatal y materna sean más altas en la altura (1) . Esto ocurre a pesar de que los pobladores de la selva presentan peores índices de pobreza que en la sierra (2) , lo que indicaría que existen factores aún no estudiados en la altura que podrían influir en el mayor número de casos. La presente revisión analiza la información existente sobre hemoglobina materna en la altura y su impacto en la salud de la madre y del recién nacido. CARACTERÍSTICAS DEL RECIÉN NACIDO EN LA ALTURAEl peso del recién nacido en la altura de Perú es menor que a nivel del mar y disminuye conforme aumenta la altitud (Figura 1); sin embargo, en las poblaciones de mayor antigüedad de residencia en la altura, como las 571 aymar...

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Comparison of effect of daily versus weekly iron supplementation during pregnancy on lipid peroxidation

Abstract: Daily supplementation with ferrous sulphate results in greater lipid peroxidation than weekly supplementation, the latter is comparable with daily iron (III)-hydroxide polymaltose complex. Lipid peroxidation levels are significantly higher in preeclampsia.

Cited by 31 publications

References 21 publications

Oxidative stress during early pregnancy and birth outcomes

Oxidative stress during early pregnancy and birth outcomes

Association of oral iron supplementation with birth outcomes in non-anaemic South Indian pregnant women

Hemoglobina materna en la salud perinatal y materna en la altura: implicancias en la región andina

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