Comparison Of Early-Stage High-Grade Serous Primary Fallopian Tube Cancers and Epithelial Ovarian Cancers: A Multicenter Study

Abstract

Introduction: We compared the disease free-survival (DFS) and overall survival (OS) rates of patients with high-grade serous primary fallopian tube cancer (HG-sPFTC) and high-grade serous epithelial ovarian cancer (HG-sEOC). Methods: 22 early-stage cancer patients (International Federation of Gynecology and Obstetrics (FIGO) stages I-II) with HG-sPFTC were retrospectively evaluated. In addition, 44 control patients diagnosed with HG-sEOC were matched to these patients with respect to tumor stage at diagnosis. All patients underwent complete surgical staging, followed by adjuvant chemotherapy. Kaplan-Meier curves were used to generate survival data. Results: The mean age of HG-sPFTC patients was 59.4 ± 6.2 years, and that of HG-sEOC patients 55.2 ± 11.0 years (p = 0.002). All patients underwent 6 cycles of platinum-based adjuvant chemotherapy. All operations were optimal. The 5-year DFSs were 77.3% for HG-sPFTC patients and 75% for HG-sEOC patients (p = 1.00).The 5-year OS rates were 81.8% in women with HG-sPFTC and 77.3% in those with HG-sEOC (p = 0.75). Conclusion: The DFS and OS rates of patients with early-stage (FIGO stages I and II) HG-sPFTC and HG-sEOC were similar. The surgical and adjuvant therapy management of these malignancies should be similar.

Medical diligence uncovers fallopian tube cancer after abnormal Pap test

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Upfront debulking surgery for high-grade serous ovarian carcinoma: current evidence

“…Patients with BRCA mutation have shown greater rates of overall survival, longer disease-free interval (DFI) after first-line chemotherapy, better responsiveness in common chemotherapeutic regimens and higher treatment free interval (TFI) between each line of therapy (18,19). For women with BRCA1/2 mutations, progression-free survival is estimated at 15.7 and 21.6 months respectively, and overall survival for both groups were approximately 55.3 and 75.2 months, respectively (15,20). In patients with ovarian carcinomas showing no BRCA 1 or 2 mutation, progression-free survival and overall survival were estimated at 16 and 56 months, showing great similarities to BRCA1 rates (21,22).…”