Comparison of early renal function parameters for the prediction of 5-year graft survival after kidney transplantation

Abstract

Routine parameters for monitoring of EGF display a threshold effect allowing accurate prediction of 5-year graft survival at the earliest point in time. The quantitative threshold levels for an optimum discriminatory power require validation in a larger, preferably multicentre database.

Effect of Brain-Dead Donor Resuscitation on Delayed Graft Function: Results of a Monocentric Analysis

“…However, we show that the model using the definition in days of DGF (Ͻ or Ն6 days) enhances the number of explanatory variables and thus is probably more interesting for the physician. Moreover, a recent study of Schnuelle showed that dialysis requirement posttransplantation was not a significant explanatory variable in the multivariate analysis of five-year graft survival contrary to the 1-week graft function, confirming our choice of DGF definition with the creatinine clearance (35).…”

Donor Quality Scoring Systems and Early Renal Function Measurements in Kidney Transplantation

“…A score based on the combination of serum creatinine at post-KT day 7 (Cr7) and urine output at post-KT day 1(UO1) was proposed (Schnuelle et al, 2007).…”

“…Survival curves of the respective controls not meeting these requirements are displayed in light-colored lines. Taken from Schnuelle et al, 2007. b. A definition of DGF obtainable within 6 hours after KT was proposed (Gonwa et al, 2002).…”

“…Indeed, the influence of pre-or post-KT dialysis on creatinine measurements independent of allograft excretory function was too great a confounder to allow meaningful interpretation of these parameters also in dialyzed patients. Exclusive (Lai et al, 2010) or combined (Schnuelle et al, 2007) use of UO could be of some benefit in a better evaluation of these patients: however, more consistent large studies on this field are still required. No comparative studies among clinical and histological scores have been reported.…”

Evaluation of Renal Transplant Scintigraphy and Resistance Index Performed Within 2 Days After Transplantation in Predicting Long-Term Graft Function

“…6 Early renal function parameters such as urine output during 24 hours after transplantation and serum creatinine (sCr) after 1 week are also valuable in estimation of long-term survival. 7 Radionuclide measurements of renal function are conveniently divided into 3 categories corresponding to the classic 3 phases of the renogram. The first phase corresponds to transit of a bolus tracer through the renal blood vessels.…”