Comparison of early onset breast cancer patients to older premenopausal breast cancer patients

Varga, Dominic; Koenig, Jochem; Kuhr, Kathrin; Strunz, K; Geyer, V.; Kurzeder, Christian; Atassi, Z.; Blettner, Maria; Kreienberg, R.; Woeckel, Achim

doi:10.1007/s00404-009-1339-y

Cited by 20 publications

(15 citation statements)

References 14 publications

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“…It is well known that breast cancers in young patients tend to behave more aggressively and possess poorer prognosis compared with cases in old patients [47,48]. Furthermore, in our study, lower TAP1 or TAP2 in primary breast cancers were both associated with poorer AJCC stage.…”

Section: Discussionsupporting

confidence: 58%

Expression of antigen processing and presenting molecules in brain metastasis of breast cancer

Liu

Komohara

Domenick

et al. 2011

Cancer Immunol Immunother

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Defects in human leukocyte antigen (HLA) class I antigen processing machinery (APM) component expression can have a negative impact on the clinical course of tumors and the response to T-cell-based immunotherapy. Since brain metastases of breast cancer are of increasing clinical significance, the APM component expression levels and CD8+ T-cell infiltration patterns were analyzed in primary breast and metastatic brain lesions of breast cancer by immunohistochemistry. Comparison of unpaired 50 primary and 33 brain metastases showed lower expression of β2-microgloblin, transporter associated with antigen processing (TAP) 1, TAP2 and calnexin in the brain lesions. Although no significant differences were found in APM component scores between primary breast and brain lesions in 15 paired cases, primary breast lesions of which patients eventually developed brain metastases showed lower levels of β2-microgloblin, TAP1 and calnexin compared with breast lesions without known brain metastases. The extent of CD8+ T cell infiltration was significantly higher in the lesions without metastasis compared with the ones with brain metastases, and was positively associated with the expression of TAP1 and calnexin. Furthermore, mouse tumor cells stably transfected with silencing hairpin (sh)RNA for TAP1 demonstrated a decreased susceptibility to cytotoxic T lymphocytes (CTL) in vitro and enhanced spontaneous brain metastasis in vivo. These data support the functional significance of TAP1 expression in tumor cells. Taken together, our data suggest that patients with low or defective TAP1 or calnexin in primary breast cancers may be at higher risks for developing brain metastasis due to the defects in T cell-based immunosurveillance.

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Section: Discussionsupporting

confidence: 58%

Expression of antigen processing and presenting molecules in brain metastasis of breast cancer

Liu

Komohara

Domenick

et al. 2011

Cancer Immunol Immunother

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“…Brazilian women have limited access to clinics that provide mammography examinations and organized population-based screening programs do not exist; consequently, the majority of the BC cases in Brazil are detected at advanced stages. This is in contrast to the situation in developed countries, where regular mammography screening enables the detection of the majority of cases of BC at an early stage (14,19,21). Indeed, prior to 2002, there was no formal recommendation from the Brazilian Health Authorities to provide mammography examinations in asymptomatic women.…”

Section: Discussionmentioning

confidence: 62%

“…Typically, the young BC age group ranges from 35 (13,18,19) to 40 (2,14,20,21), however, there is no clear consensus supporting these strict age limits for young and old. However, BC is more frequent in women aged >50 years old.…”

Section: Discussionmentioning

confidence: 99%

Retrospective analysis of breast cancer prognosis among young and older women in a Brazilian cohort of 738 patients, 1985–2002

et al. 2016

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Invasive breast cancer (BC) is infrequent among women aged ≤40 years, however, the disease outlook in these younger patients is generally worse than among older women. The present study aimed to compare socio-demographic, clinical and pathological characteristics, and their association with long-term survival, between two random cohorts of young (≤40 years) and older (50–69 years) Brazilian patients with BC. The cohort comprised of 738 randomly selected women who were diagnosed with BC at Barretos Cancer Hospital, Pio XII Foundation (Barretos, Brazil) between January 1985 and December 2002; the patients included young women (n=376) and older women (n=362). The current analysis suggested that BC in young women is associated with numerous pathological features of aggressiveness. Second cancer and bilateral BC were independent predictors of a poor outcome in the younger group. Furthermore, C-erB-2 was positively correlated with poor outcome in the older group, whereas estrogen receptor status and TNM stage were associated with disease prognosis in both groups. The overall survival rates of the two age groups were similar except when analyzed according the treatment period (1997–2002). Although patients aged ≤40 years harbored tumors with more aggressive clinicopathological characteristics, these characteristics were not independent predictors of overall survival. The present study indicates that medical advances associated with prevention of breast cancer may improve screening programs, which may therefore increase early diagnosis and subsequently lower mortality rates.

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“…Les données concernant le lien entre âge, taille tumorale, atteinte ganglionnaire et statut HER2 sont plus controversées [4,7,41,59,83,94,171], avec des discordances qui, pour le dernier paramètre, peuvent être rapportées aux techniques de mesure qui ne sont pas homogènes pour les études les plus anciennes. Il a également été retrouvé une plus grande incidence des formes infl ammatoires chez les femmes plus jeunes [31].…”

Section: Généralités Particularités Biologiques Des Cancers Du Sein Dunclassified

Prise en charge du cancer du sein infiltrant de la femme âgée de 40 ans ou moins

Chauvet¹,

Debled²,

Decanter³

et al. 2011

Oncologie

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Comparison of early onset breast cancer patients to older premenopausal breast cancer patients

Cited by 20 publications

References 14 publications

Expression of antigen processing and presenting molecules in brain metastasis of breast cancer

Expression of antigen processing and presenting molecules in brain metastasis of breast cancer

Retrospective analysis of breast cancer prognosis among young and older women in a Brazilian cohort of 738 patients, 1985–2002

Prise en charge du cancer du sein infiltrant de la femme âgée de 40 ans ou moins

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