Comparison of dysprosium DTPA BMA and superparamagnetic iron oxide particles as susceptibility contrast agents for perfusion imaging of regional cerebral ischemia in the rat

Haraldseth, Olav; Jones, Richard A.; Müller, Tomm B.; Fahlvik, Anne K.; Øksendal, Audun N.

doi:10.1002/jmri.1880060503

Cited by 29 publications

(13 citation statements)

References 21 publications

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“…Abnormal signal changes were observed in all experimental rats after the middle cerebral artery was occluded with line embolism for 1 h. 4 were not significantly different between Groups A and B, which further supports our conclusions.…”

Section: Zhang Sx Et Al: Dsc-mr Perfusion Weighted Imaging and Rat Csupporting

confidence: 88%

“…The rCBV, rMTT and TTP values of ROI 3 and ROI 4 from Groups A and B were not significantly different (p > 0.05). The rrCBV of Group A were 0.36 ± 0.08 and 0.61 ± 0.10, respectively, and those of Group B were 0.39 ± 0.08 and 0.63 ± 0.12, respectively.…”

Section: General Datamentioning

confidence: 79%

“…The signal intensity-time curves of ROI 1 , ROI 2 , ROI 3 , ROI 4 were almost identical between Groups A and B. The curves of the central area of the lesion ((ROI a1 and ROI b1 ) did not show an obvious peak, but showed the formation of perfusion defects.…”

Section: General Datamentioning

confidence: 79%

“…The signal intensitytime curves corresponding to ROI 1 , ROI 2 , ROI 3 , ROI 4 of Groups A and B were almost identical, whereas the curves of the central area of the lesion did not show an obvious peak, indicating the formation of perfusion defects because of reduced perfusion of contrast agent. The curves of the edge area of the lesion indicated the peak was delayed and the time of recovery to a steady state was prolonged, while the curves corresponding to the contralateral normal hemispheres of ROI 3 and ROI 4 all maintained normal morphology.…”

Section: Zhang Sx Et Al: Dsc-mr Perfusion Weighted Imaging and Rat Cmentioning

confidence: 90%

“…Four regions of interest (ROI) of the same size were selected for analysis: one was in the central area of the lesion, one was at the edge of the lesion (i.e., half dark band in the image), and the two others were located at the corresponding anatomical positions in the contralateral brain hemispheres. The selected ROIs were expressed as ROI 1 , ROI 2 , ROI 3 , ROI 4 , respectively. The corresponding negative enhancement signal intensity-time curve was obtained for each ROI, and the data obtained were entered into the appropriate software program to calculate the cerebral blood volume (CBV), cerebral blood flow (CBF), and mean transition time (MTT) values.…”

Section: Image Processing and Data Analysismentioning

confidence: 99%

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Application value of resovist on the dsc-mr perfusion weighted imaging in rat hyperacute cerebral infarction

Zhang¹,

Chen²,

Chen³

et al. 2013

Turkish Neurosurgery

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AIm:The aim of this study was to evaluate the use of Resovist in perfusion-weighted imaging (PWI) of rat hyperacute cerebral infarction. mATERIAL and mETHods: 30 Wistar rats were randomly divided into 2 groups. Group A was intravenously injected with 8 μmol Fe/kg body weight of Resovist, whilst Group B was injected with 0.2 mmol/kg body weight of Gd-DTPA. These dosages were chosen to provide comparable maximum signal changes in normally perfused brain. CBV, CBF and MTT parameter profiles were obtained for the core diseased region and the penumbra of brain ischemia and compared between the two groups. These results were then correlated with pathological findings and TTC staining. REsuLTs:In our rat stroke model, signal-time curves were similar between Gd-DTPA and Resovist, both in the core area with severe ischemia and in the penumbra area with moderate ischemia. The CBV, MTT, and TTP values of PWI for ischemic penumbra in Groups A and B showed no statistical disparity. CoNCLusIoN:The efficacy of Resovist in MR PWI is similar to Gd-DTPA in the diagnosis of perfusion reduction in the rat stroke model.

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Section: Zhang Sx Et Al: Dsc-mr Perfusion Weighted Imaging and Rat Csupporting

confidence: 88%

Section: General Datamentioning

confidence: 79%

Section: General Datamentioning

confidence: 79%

Section: Zhang Sx Et Al: Dsc-mr Perfusion Weighted Imaging and Rat Cmentioning

confidence: 90%

Section: Image Processing and Data Analysismentioning

confidence: 99%

See 3 more Smart Citations

Application value of resovist on the dsc-mr perfusion weighted imaging in rat hyperacute cerebral infarction

Zhang¹,

Chen²,

Chen³

et al. 2013

Turkish Neurosurgery

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Comparison of iron oxide particles (AMI 227) with a gadolinium complex (Gd-DOTA) in dynamic susceptibility contrast MR imagings (FLASH and EPI) for both phantom and rat brain at 1.5 tesla

Loubeyre¹,

Jaegere²,

Bosmans³

et al. 1999

J. Magn. Reson. Imaging

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The goal of the study was to compare, in phantom and normally perfused rat brain tissue, a superparamagnetic iron oxide particle‐based contrast agent (AMI 227) with a low‐molecular‐weight gadolinium chelate, gadolinium tetraazacyclododecanetetraacetic acid (Gd‐DOTA), in two susceptibility contrast magnetic resonance imaging (MRI) modes [fast low‐angle shot sequence (FLASH) and echoplanar imaging (EPI)]. A phantom consisting of dilution series of both contrast agents was manufactured. Dilutions were obtained with isotonic serum from the available agent solutions (0.5 mmol Gd/mL Gd‐DOTA; 350 μmol Fe/mL AMI 227). Eighteen rats were studied. Contrast agent (0.1 mL) was bolus injected in each rat, and dynamic MRI was performed (first pass of the contrast agent) in rat brain. The doses of AMI 227 injected were extrapolated from the phantom experiment: 0.2 mmol/kg body weight of Gd‐DOTA and 7, 14, and 28 μmol Fe/kg body weight of AMI 227 were injected. For both sequences, signal‐to‐noise ratios (S/N) were measured on each tube of the phantom and on rat brain from each image of the dynamic imaging. S/N was plotted versus contrast dilution (phantom) and versus time (rats). In the FLASH sequence, a well‐shaped curve (S/N decrease, S/N peak decrease, S/N increase) of the first pass of the contrast agent was demonstrated for Gd‐DOTA and for AMI 227 (7 μmol Fe/kg body weight ). In the EPI sequence, a well‐shaped curve was demonstrated for Gd‐DOTA, and a plateau effect was noted for both concentrations of AMI 227. With the FLASH technique, dynamic susceptibility contrast imaging of rat brain can be performed with very low concentrations of AMI 227 compared with the Gd‐DOTA concentration (0.2 mmol Gd/kg body weight) used in clinical practice. This could be of interest in perfusion imaging, because it may allow for first‐pass susceptibility imaging after administration of a small volume in a narrow bolus.J. Magn. Reson. Imaging 1999; 9:447–453. © 1999 Wiley‐Liss, Inc.

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Myocardial ?low reflow? assessed by Dy-DTPA-BMA-enhanced first-pass MR imaging in a dog model

Artéaga

Revel

Zhao

et al. 1999

J. Magn. Reson. Imaging

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The aim of this study was to determine whether the use of a magnetic resonance (MR) susceptibility contrast medium, dysprosium diethylenetriamine pentaacetic acid‐bismethylamide (Dy DTPA‐BMA; Sprodiamide), may characterize myocardial perfusion abnormalities in a dog model of 90 minutes of coronary occlusion followed by 24 hours of reperfusion (no‐reflow phenomenon installed). First‐pass MR imaging after an intravenous bolus administration of the contrast agent was performed at the end of reperfusion. Signal intensity analysis on MR imaging, planimetry of pathological data, and blood flow determination were obtained by reference methods for comparison. Dogs were separated into two groups according to the level of collateral blood flow level (group I, <22.5 % of the flow in the non‐ischemic zone; group II, >22.5 % of the flow in the non‐ischemic zone). Signal intensity‐time curves in the ischemic and non‐ischemic left ventricle walls were extracted. Mean collateral blood flow was lower during occlusion in group I (9.8 ± 5.4%, n = 5) than in group II (38 ± 12.5%, n = 7, P < 0.05). Mean infarct size (expressed as a percentage of the area at risk) was significantly larger in group I (low collateral blood flow; 25.3 ± 14.6%) than in group II (high collateral blood flow; 5.8 ± 1.1%, P < 0.05). After rapid injection, a transient decrease of signal intensity induced by Dy DTPA‐BMA was observed in both remote and ischemic myocardium but more markedly in remote normally perfused myocardium. Hence, during the transit of a susceptibility‐type contrast agent, ischemic myocardium after ischemia and reperfusion appeared as a relative high signal intensity area. First‐pass MR imaging with susceptibility contrast agent demonstrated the no‐ or low‐reflow phenomenon. However, the behavior of the myocardial signal intensity–time‐related curves did not allow distinction between the two groups of dogs. J. Magn. Reson. Imaging 9:679–684, 1999. © 1999 Wiley‐Liss, Inc.

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Comparison of dysprosium DTPA BMA and superparamagnetic iron oxide particles as susceptibility contrast agents for perfusion imaging of regional cerebral ischemia in the rat

Cited by 29 publications

References 21 publications

Application value of resovist on the dsc-mr perfusion weighted imaging in rat hyperacute cerebral infarction

Application value of resovist on the dsc-mr perfusion weighted imaging in rat hyperacute cerebral infarction

Comparison of iron oxide particles (AMI 227) with a gadolinium complex (Gd-DOTA) in dynamic susceptibility contrast MR imagings (FLASH and EPI) for both phantom and rat brain at 1.5 tesla

Myocardial ?low reflow? assessed by Dy-DTPA-BMA-enhanced first-pass MR imaging in a dog model

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