Comparison of Drusen Volume Assessed by Two Different OCT Devices

Abstract

To compare drusen volume between Heidelberg Spectral Domain (SD-) and Zeiss Swept-Source (SS) PlexElite Optical Coherence Tomography (OCT) determined by manual and automated segmentation methods. Thirty-two eyes of 24 patients with Age-Related Macular Degeneration (AMD) and drusen maculopathy were included. In the central 1 and 3 mm ETDRS circle drusen volumes were calculated and compared. Drusen segmentation was performed using automated manufacturer algorithms of the two OCT devices. Then, the automated segmentation was manually corrected and compared and finally analyzed using customized software. Though on SD-OCT, there was a significant difference of mean drusen volume prior to and after manual correction (mean difference: 0.0188 ± 0.0269 mm3, p < 0.001, corr. p < 0.001, correlation of r = 0.90), there was no difference found on SS-OCT (mean difference: 0.0001 ± 0.0003 mm3, p = 0.262, corr. p = 0.524, r = 1.0). Heidelberg-acquired mean drusen volume after manual correction was significantly different from Zeiss-acquired drusen volume after manual correction (mean difference: 0.1231 ± 0.0371 mm3, p < 0.001, corr. p < 0.001, r = 0.68). Using customized software, the difference of measurements between both devices decreased and correlation among the measurements improved (mean difference: 0.0547 ± 0.0744 mm3, p = 0.02, corr. p = 0.08, r = 0.937). Heidelberg SD-OCT, the Zeiss PlexElite SS-OCT, and customized software all measured significantly different drusen volumes. Therefore, devices/algorithms may not be interchangeable. Third-party customized software helps to minimize differences, which may allow a pooling of data of different devices, e.g., in multicenter trials.

Retinal clinical and morphofunctional changes in high myopia in combination with age-related macular degeneration of different stages

“…Участки ГА с выраженной гипоаутофлуоресценцией выявлены у 23 % (10 человек, 17 глаз), среди которых унифокальные области ГА были у 8 % (3 человека, 6 глаз), мультифокальные области ГА -у 15 % (7 человек, 11 глаз). Данные изменения были описаны в работах других авторов [20][21][22][28][29][30].…”

“…Достаточно исчерпывающую и точную информацию о состоянии сетчатки нам дает оптическая когерентная томография (ОКТ) [16][17][18][19][20][21][22][23]. Однако исследований, которые посвящены использованию ОКТ с аутофлуоресценцией (АФ) глазного дна при сочетании миопии высокой степени с разными стадиями ВМД, практически нет [24][25][26][27][28].…”

Automatic Segmentation of the Retinal Nerve Fiber Layer by Means of Mathematical Morphology and Deformable Models in 2D Optical Coherence Tomography Imaging

“…This fact makes it difficult to compare measurements between equipment from different brands as well as with implementations based on recent research. For example, as addressed in [ 25 ], the authors highlight the differences in manual and automated segmentation in drusen volume from a Heidelberg spectral domain (SD-) and a Zeiss swept-source (SS) PlexElite optical coherence tomography (OCT).…”

“…In recent years, the segmentation and analysis of retinal layers in OCT images and their clinical implications have focused the efforts of many researchers [ 22 ]. Besides the RNFL, researchers particularize their methods to detect and segment in OCT images some retinal abnormalities such as exudate-associated derangements [ 23 ], drusen volume [ 24 , 25 ], neovascularizations [ 26 ], intraretinal cysts [ 27 ], or to assess the presence and quantity of intraretinal and subretinal fluids [ 28 ] and image-guided treatment management [ 29 , 30 ]. Focusing on the RFNL, it was initially differentiated from other retinal layers in OCT imaging using a thresholding algorithm that detected the anterior edge of retinal pigment epithelium and determined the photoreceptor layer position.…”

Retinal Progression Biomarkers of Early and Intermediate Age-Related Macular Degeneration

“…Improved visualization of external layers with SS-OCT devices, provides better automated segmentation performances, and more concordance in manual and automated measurements of drusen volume. Even more, some authors found no significant differences in drusen volume prior to and after manual correction in SS-OCT compared with a significant difference in SD-OCT devices [38].…”